Structure of Type-I Mycobacterium tuberculosis fatty acid synthase at 3.3 Å resolution

The type-I fatty acid synthase (FAS-I) complex is essential for Mycobacterium tuberculosis (Mtb) and mediates the production of C26 fatty acids that are precursors for the synthesis of mycolic acids. Here the authors present the 3.3 Å resolution cryo-EM structure of Mtb FAS-I, which is of interest f...

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Autores principales:	Nadav Elad, Szilvia Baron, Yoav Peleg, Shira Albeck, Jacob Grunwald, Gal Raviv, Zippora Shakked, Oren Zimhony, Ron Diskin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/11b0d9221adb4b1bbbacb74016a4bfa6
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spelling	oai:doaj.org-article:11b0d9221adb4b1bbbacb74016a4bfa62021-12-02T15:34:46ZStructure of Type-I Mycobacterium tuberculosis fatty acid synthase at 3.3 Å resolution10.1038/s41467-018-06440-62041-1723https://doaj.org/article/11b0d9221adb4b1bbbacb74016a4bfa62018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06440-6https://doaj.org/toc/2041-1723The type-I fatty acid synthase (FAS-I) complex is essential for Mycobacterium tuberculosis (Mtb) and mediates the production of C26 fatty acids that are precursors for the synthesis of mycolic acids. Here the authors present the 3.3 Å resolution cryo-EM structure of Mtb FAS-I, which is of interest for tuberculosis drug development.Nadav EladSzilvia BaronYoav PelegShira AlbeckJacob GrunwaldGal RavivZippora ShakkedOren ZimhonyRon DiskinNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-6 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nadav Elad Szilvia Baron Yoav Peleg Shira Albeck Jacob Grunwald Gal Raviv Zippora Shakked Oren Zimhony Ron Diskin Structure of Type-I Mycobacterium tuberculosis fatty acid synthase at 3.3 Å resolution
description	The type-I fatty acid synthase (FAS-I) complex is essential for Mycobacterium tuberculosis (Mtb) and mediates the production of C26 fatty acids that are precursors for the synthesis of mycolic acids. Here the authors present the 3.3 Å resolution cryo-EM structure of Mtb FAS-I, which is of interest for tuberculosis drug development.
format	article
author	Nadav Elad Szilvia Baron Yoav Peleg Shira Albeck Jacob Grunwald Gal Raviv Zippora Shakked Oren Zimhony Ron Diskin
author_facet	Nadav Elad Szilvia Baron Yoav Peleg Shira Albeck Jacob Grunwald Gal Raviv Zippora Shakked Oren Zimhony Ron Diskin
author_sort	Nadav Elad
title	Structure of Type-I Mycobacterium tuberculosis fatty acid synthase at 3.3 Å resolution
title_short	Structure of Type-I Mycobacterium tuberculosis fatty acid synthase at 3.3 Å resolution
title_full	Structure of Type-I Mycobacterium tuberculosis fatty acid synthase at 3.3 Å resolution
title_fullStr	Structure of Type-I Mycobacterium tuberculosis fatty acid synthase at 3.3 Å resolution
title_full_unstemmed	Structure of Type-I Mycobacterium tuberculosis fatty acid synthase at 3.3 Å resolution
title_sort	structure of type-i mycobacterium tuberculosis fatty acid synthase at 3.3 å resolution
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/11b0d9221adb4b1bbbacb74016a4bfa6
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Structure of Type-I Mycobacterium tuberculosis fatty acid synthase at 3.3 Å resolution

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