MiR-205-driven downregulation of cholesterol biosynthesis through SQLE-inhibition identifies therapeutic vulnerability in aggressive prostate cancer

MiR-205-driven downregulation of cholesterol biosynthesis through SQLE-inhibition identifies therapeutic vulnerability in aggressive prostate cancer

Cholesterol metabolism is involved in the progression of aggressive prostate cancer (PCa). Here the authors show that miR-205 downregulation promotes cholesterol synthesis and androgen receptor signalling in PCa through enhancing the expression of the rate-limiting enzyme of cholesterol synthesis, s...

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Autores principales: C. Kalogirou, J. Linxweiler, P. Schmucker, M. T. Snaebjornsson, W. Schmitz, S. Wach, M. Krebs, E. Hartmann, M. Puhr, A. Müller, M. Spahn, A. K. Seitz, T. Frank, H. Marouf, G. Büchel, M. Eckstein, H. Kübler, M. Eilers, M. Saar, K. Junker, F. Röhrig, B. Kneitz, M. T. Rosenfeldt, A. Schulze
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/11b1a821ae93404d9aff913722f3970e
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Sumario:Cholesterol metabolism is involved in the progression of aggressive prostate cancer (PCa). Here the authors show that miR-205 downregulation promotes cholesterol synthesis and androgen receptor signalling in PCa through enhancing the expression of the rate-limiting enzyme of cholesterol synthesis, squalene epoxidase.

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