MiR-205-driven downregulation of cholesterol biosynthesis through SQLE-inhibition identifies therapeutic vulnerability in aggressive prostate cancer

Cholesterol metabolism is involved in the progression of aggressive prostate cancer (PCa). Here the authors show that miR-205 downregulation promotes cholesterol synthesis and androgen receptor signalling in PCa through enhancing the expression of the rate-limiting enzyme of cholesterol synthesis, s...

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Autores principales:	C. Kalogirou, J. Linxweiler, P. Schmucker, M. T. Snaebjornsson, W. Schmitz, S. Wach, M. Krebs, E. Hartmann, M. Puhr, A. Müller, M. Spahn, A. K. Seitz, T. Frank, H. Marouf, G. Büchel, M. Eckstein, H. Kübler, M. Eilers, M. Saar, K. Junker, F. Röhrig, B. Kneitz, M. T. Rosenfeldt, A. Schulze
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/11b1a821ae93404d9aff913722f3970e
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spelling	oai:doaj.org-article:11b1a821ae93404d9aff913722f3970e2021-12-02T16:45:48ZMiR-205-driven downregulation of cholesterol biosynthesis through SQLE-inhibition identifies therapeutic vulnerability in aggressive prostate cancer10.1038/s41467-021-25325-92041-1723https://doaj.org/article/11b1a821ae93404d9aff913722f3970e2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25325-9https://doaj.org/toc/2041-1723Cholesterol metabolism is involved in the progression of aggressive prostate cancer (PCa). Here the authors show that miR-205 downregulation promotes cholesterol synthesis and androgen receptor signalling in PCa through enhancing the expression of the rate-limiting enzyme of cholesterol synthesis, squalene epoxidase.C. KalogirouJ. LinxweilerP. SchmuckerM. T. SnaebjornssonW. SchmitzS. WachM. KrebsE. HartmannM. PuhrA. MüllerM. SpahnA. K. SeitzT. FrankH. MaroufG. BüchelM. EcksteinH. KüblerM. EilersM. SaarK. JunkerF. RöhrigB. KneitzM. T. RosenfeldtA. SchulzeNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q C. Kalogirou J. Linxweiler P. Schmucker M. T. Snaebjornsson W. Schmitz S. Wach M. Krebs E. Hartmann M. Puhr A. Müller M. Spahn A. K. Seitz T. Frank H. Marouf G. Büchel M. Eckstein H. Kübler M. Eilers M. Saar K. Junker F. Röhrig B. Kneitz M. T. Rosenfeldt A. Schulze MiR-205-driven downregulation of cholesterol biosynthesis through SQLE-inhibition identifies therapeutic vulnerability in aggressive prostate cancer
description	Cholesterol metabolism is involved in the progression of aggressive prostate cancer (PCa). Here the authors show that miR-205 downregulation promotes cholesterol synthesis and androgen receptor signalling in PCa through enhancing the expression of the rate-limiting enzyme of cholesterol synthesis, squalene epoxidase.
format	article
author	C. Kalogirou J. Linxweiler P. Schmucker M. T. Snaebjornsson W. Schmitz S. Wach M. Krebs E. Hartmann M. Puhr A. Müller M. Spahn A. K. Seitz T. Frank H. Marouf G. Büchel M. Eckstein H. Kübler M. Eilers M. Saar K. Junker F. Röhrig B. Kneitz M. T. Rosenfeldt A. Schulze
author_facet	C. Kalogirou J. Linxweiler P. Schmucker M. T. Snaebjornsson W. Schmitz S. Wach M. Krebs E. Hartmann M. Puhr A. Müller M. Spahn A. K. Seitz T. Frank H. Marouf G. Büchel M. Eckstein H. Kübler M. Eilers M. Saar K. Junker F. Röhrig B. Kneitz M. T. Rosenfeldt A. Schulze
author_sort	C. Kalogirou
title	MiR-205-driven downregulation of cholesterol biosynthesis through SQLE-inhibition identifies therapeutic vulnerability in aggressive prostate cancer
title_short	MiR-205-driven downregulation of cholesterol biosynthesis through SQLE-inhibition identifies therapeutic vulnerability in aggressive prostate cancer
title_full	MiR-205-driven downregulation of cholesterol biosynthesis through SQLE-inhibition identifies therapeutic vulnerability in aggressive prostate cancer
title_fullStr	MiR-205-driven downregulation of cholesterol biosynthesis through SQLE-inhibition identifies therapeutic vulnerability in aggressive prostate cancer
title_full_unstemmed	MiR-205-driven downregulation of cholesterol biosynthesis through SQLE-inhibition identifies therapeutic vulnerability in aggressive prostate cancer
title_sort	mir-205-driven downregulation of cholesterol biosynthesis through sqle-inhibition identifies therapeutic vulnerability in aggressive prostate cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/11b1a821ae93404d9aff913722f3970e
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MiR-205-driven downregulation of cholesterol biosynthesis through SQLE-inhibition identifies therapeutic vulnerability in aggressive prostate cancer

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