The Role of Cytokines in the Development of Early Pregnancy Loss in Women with a History of Metabolic Disorders

Background. Spontaneous miscarriage is the most common complication of pregnancy. Obesity increases the risk of adverse pregnancy outcomes. Aim of the study. To assess the cytokine profile as a marker of spontaneous miscarriage in women with metabolic disorders in the past medical history. Materials...

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Autores principales:	I. V. Zhukоvets, O. Y. Leshchenko, I. A. Andrievskaya, K. K. Petrova
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2020
Materias:	metabolic disorders interleukins spontaneous miscarriage Science Q
Acceso en línea:	https://doaj.org/article/11b26bd8af4343ebb42307e9d1119641
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spelling	oai:doaj.org-article:11b26bd8af4343ebb42307e9d11196412021-11-23T06:14:44ZThe Role of Cytokines in the Development of Early Pregnancy Loss in Women with a History of Metabolic Disorders2541-94202587-959610.29413/ABS.2020-5.4.1https://doaj.org/article/11b26bd8af4343ebb42307e9d11196412020-09-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/2386https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Background. Spontaneous miscarriage is the most common complication of pregnancy. Obesity increases the risk of adverse pregnancy outcomes. Aim of the study. To assess the cytokine profile as a marker of spontaneous miscarriage in women with metabolic disorders in the past medical history. Materials and methods. A prospective study of 170 adolescent girls with metabolic disorders was conducted between 2000 and 2013. Assessment of menstrual and reproductive function was carried out in 86, pregnancy outcomes – in 72 women. The average age of women in reproductive age was 21.95 ± 0.2 years, BMI – 24.7 ± 3.9 kg/m2. Results. In women with early pregnancy losses and metabolic disorders in past medical history, the predictor of an early pregnancy loss is an increase in the ratio of pro- and anti-inflammatory cytokines TNF-a/IL-10 in serum at 7–8 weeks of gestation (OR = 2.29). It was determined a significant correlation between the levels of pro- and anti-inflammatory cytokines of the same name in serum and chorion (IL-10 (p = 0.000) and TNF-α/IL-10 (p = 0.001), which indicates similar changes in chorion. The activity of NF-kB in chorion was 5.75 ± 0.51 pg/ml. Conclusions. The findings suggest that the cytokine balance of pro- and anti-inflammatory cytokines in women with metabolic disorders in past medical history is an important component in the development of early pregnancy losses.I. V. ZhukоvetsO. Y. LeshchenkoI. A. AndrievskayaK. K. PetrovaScientific Сentre for Family Health and Human Reproduction Problemsarticlemetabolic disordersinterleukinsspontaneous miscarriageScienceQRUActa Biomedica Scientifica, Vol 5, Iss 4, Pp 8-13 (2020)
institution	DOAJ
collection	DOAJ
language	RU
topic	metabolic disorders interleukins spontaneous miscarriage Science Q
spellingShingle	metabolic disorders interleukins spontaneous miscarriage Science Q I. V. Zhukоvets O. Y. Leshchenko I. A. Andrievskaya K. K. Petrova The Role of Cytokines in the Development of Early Pregnancy Loss in Women with a History of Metabolic Disorders
description	Background. Spontaneous miscarriage is the most common complication of pregnancy. Obesity increases the risk of adverse pregnancy outcomes. Aim of the study. To assess the cytokine profile as a marker of spontaneous miscarriage in women with metabolic disorders in the past medical history. Materials and methods. A prospective study of 170 adolescent girls with metabolic disorders was conducted between 2000 and 2013. Assessment of menstrual and reproductive function was carried out in 86, pregnancy outcomes – in 72 women. The average age of women in reproductive age was 21.95 ± 0.2 years, BMI – 24.7 ± 3.9 kg/m2. Results. In women with early pregnancy losses and metabolic disorders in past medical history, the predictor of an early pregnancy loss is an increase in the ratio of pro- and anti-inflammatory cytokines TNF-a/IL-10 in serum at 7–8 weeks of gestation (OR = 2.29). It was determined a significant correlation between the levels of pro- and anti-inflammatory cytokines of the same name in serum and chorion (IL-10 (p = 0.000) and TNF-α/IL-10 (p = 0.001), which indicates similar changes in chorion. The activity of NF-kB in chorion was 5.75 ± 0.51 pg/ml. Conclusions. The findings suggest that the cytokine balance of pro- and anti-inflammatory cytokines in women with metabolic disorders in past medical history is an important component in the development of early pregnancy losses.
format	article
author	I. V. Zhukоvets O. Y. Leshchenko I. A. Andrievskaya K. K. Petrova
author_facet	I. V. Zhukоvets O. Y. Leshchenko I. A. Andrievskaya K. K. Petrova
author_sort	I. V. Zhukоvets
title	The Role of Cytokines in the Development of Early Pregnancy Loss in Women with a History of Metabolic Disorders
title_short	The Role of Cytokines in the Development of Early Pregnancy Loss in Women with a History of Metabolic Disorders
title_full	The Role of Cytokines in the Development of Early Pregnancy Loss in Women with a History of Metabolic Disorders
title_fullStr	The Role of Cytokines in the Development of Early Pregnancy Loss in Women with a History of Metabolic Disorders
title_full_unstemmed	The Role of Cytokines in the Development of Early Pregnancy Loss in Women with a History of Metabolic Disorders
title_sort	role of cytokines in the development of early pregnancy loss in women with a history of metabolic disorders
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2020
url	https://doaj.org/article/11b26bd8af4343ebb42307e9d1119641
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The Role of Cytokines in the Development of Early Pregnancy Loss in Women with a History of Metabolic Disorders

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