Managing peptic ulcer and gastroesophageal reflux disease in elderly Chinese patients – focus on esomeprazole

Managing peptic ulcer and gastroesophageal reflux disease in elderly Chinese patients – focus on esomeprazole

Raymond SY Tang, Justin CY Wu Institute of Digestive Disease, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong Abstract: Peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD) are not uncommon in elderly patients. Clinical presentation...

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Autores principales: Tang RS, Wu JC
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2013
Materias:
Geriatrics
RC952-954.6
Acceso en línea:https://doaj.org/article/11b3ce88e9e840bc8f134a652868f9a4
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spelling oai:doaj.org-article:11b3ce88e9e840bc8f134a652868f9a42021-12-02T03:26:42ZManaging peptic ulcer and gastroesophageal reflux disease in elderly Chinese patients – focus on esomeprazole1178-1998https://doaj.org/article/11b3ce88e9e840bc8f134a652868f9a42013-10-01T00:00:00Zhttps://www.dovepress.com/managing-peptic-ulcer-and-gastroesophageal-reflux-disease-in-elderly-c-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Raymond SY Tang, Justin CY Wu Institute of Digestive Disease, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong Abstract: Peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD) are not uncommon in elderly patients. Clinical presentations of these acid-related disorders may be atypical in the geriatric population. Older individuals are at increased risk for poor outcomes in complicated PUD and for development of GERD complications. Multiple risk factors (eg, Helicobacter pylori [HP], use of nonsteroidal anti-inflammatory drugs [NSAIDs], aspirin) contribute to the development of PUD. Recent data has shown that HP-negative, NSAID-negative idiopathic peptic ulcers are on the rise and carry a higher risk of recurrent ulcer bleeding and mortality. Effective management of PUD in the geriatric population relies on identification and modification of treatable risk factors. Elderly patients with GERD often require long-term acid suppressive therapy. Proton pump inhibitors (PPI) including esomeprazole are effective in the treatment of reflux esophagitis, maintenance of GERD symptomatic control, and management of PUD as well as its complications. Potential safety concerns of long-term PPI use have been reported in the literature. Clinicians should balance the risks and benefits before committing elderly patients to long-term PPI therapy. Keywords: elderly patients, peptic ulcer disease, gastroesophageal reflux disease, proton pump inhibitor, esomeprazoleTang RSWu JCDove Medical PressarticleGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 8, Pp 1433-1443 (2013)
institution DOAJ
collection DOAJ
language EN
topic Geriatrics
RC952-954.6
spellingShingle Geriatrics
RC952-954.6
Tang RS
Wu JC
Managing peptic ulcer and gastroesophageal reflux disease in elderly Chinese patients – focus on esomeprazole
description Raymond SY Tang, Justin CY Wu Institute of Digestive Disease, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong Abstract: Peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD) are not uncommon in elderly patients. Clinical presentations of these acid-related disorders may be atypical in the geriatric population. Older individuals are at increased risk for poor outcomes in complicated PUD and for development of GERD complications. Multiple risk factors (eg, Helicobacter pylori [HP], use of nonsteroidal anti-inflammatory drugs [NSAIDs], aspirin) contribute to the development of PUD. Recent data has shown that HP-negative, NSAID-negative idiopathic peptic ulcers are on the rise and carry a higher risk of recurrent ulcer bleeding and mortality. Effective management of PUD in the geriatric population relies on identification and modification of treatable risk factors. Elderly patients with GERD often require long-term acid suppressive therapy. Proton pump inhibitors (PPI) including esomeprazole are effective in the treatment of reflux esophagitis, maintenance of GERD symptomatic control, and management of PUD as well as its complications. Potential safety concerns of long-term PPI use have been reported in the literature. Clinicians should balance the risks and benefits before committing elderly patients to long-term PPI therapy. Keywords: elderly patients, peptic ulcer disease, gastroesophageal reflux disease, proton pump inhibitor, esomeprazole
format article
author Tang RS
Wu JC
author_facet Tang RS
Wu JC
author_sort Tang RS
title Managing peptic ulcer and gastroesophageal reflux disease in elderly Chinese patients – focus on esomeprazole
title_short Managing peptic ulcer and gastroesophageal reflux disease in elderly Chinese patients – focus on esomeprazole
title_full Managing peptic ulcer and gastroesophageal reflux disease in elderly Chinese patients – focus on esomeprazole
title_fullStr Managing peptic ulcer and gastroesophageal reflux disease in elderly Chinese patients – focus on esomeprazole
title_full_unstemmed Managing peptic ulcer and gastroesophageal reflux disease in elderly Chinese patients – focus on esomeprazole
title_sort managing peptic ulcer and gastroesophageal reflux disease in elderly chinese patients – focus on esomeprazole
publisher Dove Medical Press
publishDate 2013
url https://doaj.org/article/11b3ce88e9e840bc8f134a652868f9a4
work_keys_str_mv AT tangrs managingpepticulcerandgastroesophagealrefluxdiseaseinelderlychinesepatientsndashfocusonesomeprazole
AT wujc managingpepticulcerandgastroesophagealrefluxdiseaseinelderlychinesepatientsndashfocusonesomeprazole
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