Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity

Tuberculosis meningitis (TBM) is a severe form of TB with limited treatment options. Here, the authors perform RNA sequencing on whole blood and on ventricular and lumbar cerebrospinal fluid (CSF) samples from pediatric patients treated for TBM to characterize the immune response and tissue damage.

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Autores principales:	Ursula K. Rohlwink, Anthony Figaji, Katalin A. Wilkinson, Stuart Horswell, Abdul K. Sesay, Armin Deffur, Nico Enslin, Regan Solomons, Ronald Van Toorn, Brian Eley, Michael Levin, Robert J. Wilkinson, Rachel P. J. Lai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/11b7cc57037a47a2b99a6a49c4d9e072
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spelling	oai:doaj.org-article:11b7cc57037a47a2b99a6a49c4d9e0722021-12-02T14:38:45ZTuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity10.1038/s41467-019-11783-92041-1723https://doaj.org/article/11b7cc57037a47a2b99a6a49c4d9e0722019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11783-9https://doaj.org/toc/2041-1723Tuberculosis meningitis (TBM) is a severe form of TB with limited treatment options. Here, the authors perform RNA sequencing on whole blood and on ventricular and lumbar cerebrospinal fluid (CSF) samples from pediatric patients treated for TBM to characterize the immune response and tissue damage.Ursula K. RohlwinkAnthony FigajiKatalin A. WilkinsonStuart HorswellAbdul K. SesayArmin DeffurNico EnslinRegan SolomonsRonald Van ToornBrian EleyMichael LevinRobert J. WilkinsonRachel P. J. LaiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ursula K. Rohlwink Anthony Figaji Katalin A. Wilkinson Stuart Horswell Abdul K. Sesay Armin Deffur Nico Enslin Regan Solomons Ronald Van Toorn Brian Eley Michael Levin Robert J. Wilkinson Rachel P. J. Lai Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity
description	Tuberculosis meningitis (TBM) is a severe form of TB with limited treatment options. Here, the authors perform RNA sequencing on whole blood and on ventricular and lumbar cerebrospinal fluid (CSF) samples from pediatric patients treated for TBM to characterize the immune response and tissue damage.
format	article
author	Ursula K. Rohlwink Anthony Figaji Katalin A. Wilkinson Stuart Horswell Abdul K. Sesay Armin Deffur Nico Enslin Regan Solomons Ronald Van Toorn Brian Eley Michael Levin Robert J. Wilkinson Rachel P. J. Lai
author_facet	Ursula K. Rohlwink Anthony Figaji Katalin A. Wilkinson Stuart Horswell Abdul K. Sesay Armin Deffur Nico Enslin Regan Solomons Ronald Van Toorn Brian Eley Michael Levin Robert J. Wilkinson Rachel P. J. Lai
author_sort	Ursula K. Rohlwink
title	Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity
title_short	Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity
title_full	Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity
title_fullStr	Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity
title_full_unstemmed	Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity
title_sort	tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/11b7cc57037a47a2b99a6a49c4d9e072
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Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity

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