Nucleoside analogue activators of cyclic AMP-independent protein kinase A of Trypanosoma

Nucleoside analogue activators of cyclic AMP-independent protein kinase A of Trypanosoma

Protein kinase A (PKA) is typically activated by cAMP. Here, Bachmaier et al. show that PKA of Trypanosoma is activated by nucleoside-related ligands, explain the ligand selectivity swap by a co-crystal structure of trypanosome PKAR, and identify potential downstream targets by phosphoproteomics.

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Detalles Bibliográficos
Autores principales: Sabine Bachmaier, Yuri Volpato Santos, Susanne Kramer, George Boniface Githure, Thomas Klöckner, Julia Pepperl, Cordula Baums, Robin Schenk, Frank Schwede, Hans-Gottfried Genieser, Jean-William Dupuy, Ignasi Forné, Axel Imhof, Jerôme Basquin, Esben Lorentzen, Michael Boshart
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/11bbd7538f8b49569c9ab62234d40504
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Descripción
Sumario:Protein kinase A (PKA) is typically activated by cAMP. Here, Bachmaier et al. show that PKA of Trypanosoma is activated by nucleoside-related ligands, explain the ligand selectivity swap by a co-crystal structure of trypanosome PKAR, and identify potential downstream targets by phosphoproteomics.

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