Nucleoside analogue activators of cyclic AMP-independent protein kinase A of Trypanosoma

Protein kinase A (PKA) is typically activated by cAMP. Here, Bachmaier et al. show that PKA of Trypanosoma is activated by nucleoside-related ligands, explain the ligand selectivity swap by a co-crystal structure of trypanosome PKAR, and identify potential downstream targets by phosphoproteomics.

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Autores principales:	Sabine Bachmaier, Yuri Volpato Santos, Susanne Kramer, George Boniface Githure, Thomas Klöckner, Julia Pepperl, Cordula Baums, Robin Schenk, Frank Schwede, Hans-Gottfried Genieser, Jean-William Dupuy, Ignasi Forné, Axel Imhof, Jerôme Basquin, Esben Lorentzen, Michael Boshart
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/11bbd7538f8b49569c9ab62234d40504
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spelling	oai:doaj.org-article:11bbd7538f8b49569c9ab62234d405042021-12-02T16:57:42ZNucleoside analogue activators of cyclic AMP-independent protein kinase A of Trypanosoma10.1038/s41467-019-09338-z2041-1723https://doaj.org/article/11bbd7538f8b49569c9ab62234d405042019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09338-zhttps://doaj.org/toc/2041-1723Protein kinase A (PKA) is typically activated by cAMP. Here, Bachmaier et al. show that PKA of Trypanosoma is activated by nucleoside-related ligands, explain the ligand selectivity swap by a co-crystal structure of trypanosome PKAR, and identify potential downstream targets by phosphoproteomics.Sabine BachmaierYuri Volpato SantosSusanne KramerGeorge Boniface GithureThomas KlöcknerJulia PepperlCordula BaumsRobin SchenkFrank SchwedeHans-Gottfried GenieserJean-William DupuyIgnasi FornéAxel ImhofJerôme BasquinEsben LorentzenMichael BoshartNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sabine Bachmaier Yuri Volpato Santos Susanne Kramer George Boniface Githure Thomas Klöckner Julia Pepperl Cordula Baums Robin Schenk Frank Schwede Hans-Gottfried Genieser Jean-William Dupuy Ignasi Forné Axel Imhof Jerôme Basquin Esben Lorentzen Michael Boshart Nucleoside analogue activators of cyclic AMP-independent protein kinase A of Trypanosoma
description	Protein kinase A (PKA) is typically activated by cAMP. Here, Bachmaier et al. show that PKA of Trypanosoma is activated by nucleoside-related ligands, explain the ligand selectivity swap by a co-crystal structure of trypanosome PKAR, and identify potential downstream targets by phosphoproteomics.
format	article
author	Sabine Bachmaier Yuri Volpato Santos Susanne Kramer George Boniface Githure Thomas Klöckner Julia Pepperl Cordula Baums Robin Schenk Frank Schwede Hans-Gottfried Genieser Jean-William Dupuy Ignasi Forné Axel Imhof Jerôme Basquin Esben Lorentzen Michael Boshart
author_facet	Sabine Bachmaier Yuri Volpato Santos Susanne Kramer George Boniface Githure Thomas Klöckner Julia Pepperl Cordula Baums Robin Schenk Frank Schwede Hans-Gottfried Genieser Jean-William Dupuy Ignasi Forné Axel Imhof Jerôme Basquin Esben Lorentzen Michael Boshart
author_sort	Sabine Bachmaier
title	Nucleoside analogue activators of cyclic AMP-independent protein kinase A of Trypanosoma
title_short	Nucleoside analogue activators of cyclic AMP-independent protein kinase A of Trypanosoma
title_full	Nucleoside analogue activators of cyclic AMP-independent protein kinase A of Trypanosoma
title_fullStr	Nucleoside analogue activators of cyclic AMP-independent protein kinase A of Trypanosoma
title_full_unstemmed	Nucleoside analogue activators of cyclic AMP-independent protein kinase A of Trypanosoma
title_sort	nucleoside analogue activators of cyclic amp-independent protein kinase a of trypanosoma
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/11bbd7538f8b49569c9ab62234d40504
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Nucleoside analogue activators of cyclic AMP-independent protein kinase A of Trypanosoma

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