Sox17 drives functional engraftment of endothelium converted from non-vascular cells

Endothelial cells (ECs) are promising strategies to treat vasculopathies but little is known about the factors that sustain EC identity and govern functional integration into vasculature after transplantation. Here the authors show that Ets factors and Sox17 convert nonvascular cells to vascular cel...

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Autores principales:	William Schachterle, Chaitanya R. Badwe, Brisa Palikuqi, Balvir Kunar, Michael Ginsberg, Raphael Lis, Masataka Yokoyama, Olivier Elemento, Joseph M. Scandura, Shahin Rafii
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/11bf9229b67e48d3aa00b6943deb460c
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spelling	oai:doaj.org-article:11bf9229b67e48d3aa00b6943deb460c2021-12-02T14:41:21ZSox17 drives functional engraftment of endothelium converted from non-vascular cells10.1038/ncomms139632041-1723https://doaj.org/article/11bf9229b67e48d3aa00b6943deb460c2017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms13963https://doaj.org/toc/2041-1723Endothelial cells (ECs) are promising strategies to treat vasculopathies but little is known about the factors that sustain EC identity and govern functional integration into vasculature after transplantation. Here the authors show that Ets factors and Sox17 convert nonvascular cells to vascular cells with stable EC identity and function.William SchachterleChaitanya R. BadweBrisa PalikuqiBalvir KunarMichael GinsbergRaphael LisMasataka YokoyamaOlivier ElementoJoseph M. ScanduraShahin RafiiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q William Schachterle Chaitanya R. Badwe Brisa Palikuqi Balvir Kunar Michael Ginsberg Raphael Lis Masataka Yokoyama Olivier Elemento Joseph M. Scandura Shahin Rafii Sox17 drives functional engraftment of endothelium converted from non-vascular cells
description	Endothelial cells (ECs) are promising strategies to treat vasculopathies but little is known about the factors that sustain EC identity and govern functional integration into vasculature after transplantation. Here the authors show that Ets factors and Sox17 convert nonvascular cells to vascular cells with stable EC identity and function.
format	article
author	William Schachterle Chaitanya R. Badwe Brisa Palikuqi Balvir Kunar Michael Ginsberg Raphael Lis Masataka Yokoyama Olivier Elemento Joseph M. Scandura Shahin Rafii
author_facet	William Schachterle Chaitanya R. Badwe Brisa Palikuqi Balvir Kunar Michael Ginsberg Raphael Lis Masataka Yokoyama Olivier Elemento Joseph M. Scandura Shahin Rafii
author_sort	William Schachterle
title	Sox17 drives functional engraftment of endothelium converted from non-vascular cells
title_short	Sox17 drives functional engraftment of endothelium converted from non-vascular cells
title_full	Sox17 drives functional engraftment of endothelium converted from non-vascular cells
title_fullStr	Sox17 drives functional engraftment of endothelium converted from non-vascular cells
title_full_unstemmed	Sox17 drives functional engraftment of endothelium converted from non-vascular cells
title_sort	sox17 drives functional engraftment of endothelium converted from non-vascular cells
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/11bf9229b67e48d3aa00b6943deb460c
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Sox17 drives functional engraftment of endothelium converted from non-vascular cells

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