M2-LIKE MACROPHAGES ARE POTENTIAL CANDIDATES FOR BRAIN STROKE OUTCOMES' TREATMENT

The safety and effectiveness of in vitro generated M2-like macrophages for treatment of patients with ischemic and hemorrhagic brain stroke in reparative and residual periods has been evaluated. A single endolumbar administration of autologous M2-like macrophages in the mean dose of 17,9 х 106 cells...

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Autores principales:	S. A. Morozov, G. V. Tomash, E. Ya. Shevela, L. V. Sakhno, A. V. Smyk, N. M. Starostina, A. A. Ostanin, E. R. Chernykh
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2012
Materias:	brain stroke m2-like macrophages Science Q
Acceso en línea:	https://doaj.org/article/11c314710e514f39a30a3afd74131f1a
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spelling	oai:doaj.org-article:11c314710e514f39a30a3afd74131f1a2021-11-23T06:14:19ZM2-LIKE MACROPHAGES ARE POTENTIAL CANDIDATES FOR BRAIN STROKE OUTCOMES' TREATMENT2541-94202587-9596https://doaj.org/article/11c314710e514f39a30a3afd74131f1a2012-05-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/901https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596The safety and effectiveness of in vitro generated M2-like macrophages for treatment of patients with ischemic and hemorrhagic brain stroke in reparative and residual periods has been evaluated. A single endolumbar administration of autologous M2-like macrophages in the mean dose of 17,9 х 106 cells was conducted in 13 patients with ischemic (n = 10) and hemorrhagic (n = 3) brain stroke. At 6 months after cells administration all the patients had clinical Improvement. NIHS score decreased from 8,6 ± 1,06 to 4,4 ± 0.55 (p = 0,0008), several patients showed the decrease of sensitiveness impairments, improvement of cognitive functions and enhanced quality of life. Thus, we demonstrated an ability of generation M2-like macrophages from patients with brain stroke. Endolumbar administration of these cells was safe andi didn't cause severe adverse effects and complications andi — in preliminary data — improvedi motional and cognitive functions.S. A. MorozovG. V. TomashE. Ya. ShevelaL. V. SakhnoA. V. SmykN. M. StarostinaA. A. OstaninE. R. ChernykhScientific Сentre for Family Health and Human Reproduction Problemsarticlebrain strokem2-like macrophagesScienceQRUActa Biomedica Scientifica, Vol 0, Iss 3(2), Pp 125-128 (2012)
institution	DOAJ
collection	DOAJ
language	RU
topic	brain stroke m2-like macrophages Science Q
spellingShingle	brain stroke m2-like macrophages Science Q S. A. Morozov G. V. Tomash E. Ya. Shevela L. V. Sakhno A. V. Smyk N. M. Starostina A. A. Ostanin E. R. Chernykh M2-LIKE MACROPHAGES ARE POTENTIAL CANDIDATES FOR BRAIN STROKE OUTCOMES' TREATMENT
description	The safety and effectiveness of in vitro generated M2-like macrophages for treatment of patients with ischemic and hemorrhagic brain stroke in reparative and residual periods has been evaluated. A single endolumbar administration of autologous M2-like macrophages in the mean dose of 17,9 х 106 cells was conducted in 13 patients with ischemic (n = 10) and hemorrhagic (n = 3) brain stroke. At 6 months after cells administration all the patients had clinical Improvement. NIHS score decreased from 8,6 ± 1,06 to 4,4 ± 0.55 (p = 0,0008), several patients showed the decrease of sensitiveness impairments, improvement of cognitive functions and enhanced quality of life. Thus, we demonstrated an ability of generation M2-like macrophages from patients with brain stroke. Endolumbar administration of these cells was safe andi didn't cause severe adverse effects and complications andi — in preliminary data — improvedi motional and cognitive functions.
format	article
author	S. A. Morozov G. V. Tomash E. Ya. Shevela L. V. Sakhno A. V. Smyk N. M. Starostina A. A. Ostanin E. R. Chernykh
author_facet	S. A. Morozov G. V. Tomash E. Ya. Shevela L. V. Sakhno A. V. Smyk N. M. Starostina A. A. Ostanin E. R. Chernykh
author_sort	S. A. Morozov
title	M2-LIKE MACROPHAGES ARE POTENTIAL CANDIDATES FOR BRAIN STROKE OUTCOMES' TREATMENT
title_short	M2-LIKE MACROPHAGES ARE POTENTIAL CANDIDATES FOR BRAIN STROKE OUTCOMES' TREATMENT
title_full	M2-LIKE MACROPHAGES ARE POTENTIAL CANDIDATES FOR BRAIN STROKE OUTCOMES' TREATMENT
title_fullStr	M2-LIKE MACROPHAGES ARE POTENTIAL CANDIDATES FOR BRAIN STROKE OUTCOMES' TREATMENT
title_full_unstemmed	M2-LIKE MACROPHAGES ARE POTENTIAL CANDIDATES FOR BRAIN STROKE OUTCOMES' TREATMENT
title_sort	m2-like macrophages are potential candidates for brain stroke outcomes' treatment
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2012
url	https://doaj.org/article/11c314710e514f39a30a3afd74131f1a
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M2-LIKE MACROPHAGES ARE POTENTIAL CANDIDATES FOR BRAIN STROKE OUTCOMES' TREATMENT

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