Interruption of lactate uptake by inhibiting mitochondrial pyruvate transport unravels direct antitumor and radiosensitizing effects

Tumor cells can fuel their metabolism with lactate. Here the authors show that inhibition of mitochondrial pyruvate carrier (MPC) blocks extracellular lactate uptake by promoting intracellular pyruvate accumulation and inhibits oxidative metabolism, ultimately resulting in cytotoxicity and radiosens...

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Autores principales:	Cyril Corbet, Estelle Bastien, Nihed Draoui, Bastien Doix, Lionel Mignion, Bénédicte F. Jordan, Arnaud Marchand, Jean-Christophe Vanherck, Patrick Chaltin, Olivier Schakman, Holger M. Becker, Olivier Riant, Olivier Feron
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/11c35a245c4e4c128676d165835a54e9
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spelling	oai:doaj.org-article:11c35a245c4e4c128676d165835a54e92021-12-02T15:33:45ZInterruption of lactate uptake by inhibiting mitochondrial pyruvate transport unravels direct antitumor and radiosensitizing effects10.1038/s41467-018-03525-02041-1723https://doaj.org/article/11c35a245c4e4c128676d165835a54e92018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03525-0https://doaj.org/toc/2041-1723Tumor cells can fuel their metabolism with lactate. Here the authors show that inhibition of mitochondrial pyruvate carrier (MPC) blocks extracellular lactate uptake by promoting intracellular pyruvate accumulation and inhibits oxidative metabolism, ultimately resulting in cytotoxicity and radiosensitization.Cyril CorbetEstelle BastienNihed DraouiBastien DoixLionel MignionBénédicte F. JordanArnaud MarchandJean-Christophe VanherckPatrick ChaltinOlivier SchakmanHolger M. BeckerOlivier RiantOlivier FeronNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Cyril Corbet Estelle Bastien Nihed Draoui Bastien Doix Lionel Mignion Bénédicte F. Jordan Arnaud Marchand Jean-Christophe Vanherck Patrick Chaltin Olivier Schakman Holger M. Becker Olivier Riant Olivier Feron Interruption of lactate uptake by inhibiting mitochondrial pyruvate transport unravels direct antitumor and radiosensitizing effects
description	Tumor cells can fuel their metabolism with lactate. Here the authors show that inhibition of mitochondrial pyruvate carrier (MPC) blocks extracellular lactate uptake by promoting intracellular pyruvate accumulation and inhibits oxidative metabolism, ultimately resulting in cytotoxicity and radiosensitization.
format	article
author	Cyril Corbet Estelle Bastien Nihed Draoui Bastien Doix Lionel Mignion Bénédicte F. Jordan Arnaud Marchand Jean-Christophe Vanherck Patrick Chaltin Olivier Schakman Holger M. Becker Olivier Riant Olivier Feron
author_facet	Cyril Corbet Estelle Bastien Nihed Draoui Bastien Doix Lionel Mignion Bénédicte F. Jordan Arnaud Marchand Jean-Christophe Vanherck Patrick Chaltin Olivier Schakman Holger M. Becker Olivier Riant Olivier Feron
author_sort	Cyril Corbet
title	Interruption of lactate uptake by inhibiting mitochondrial pyruvate transport unravels direct antitumor and radiosensitizing effects
title_short	Interruption of lactate uptake by inhibiting mitochondrial pyruvate transport unravels direct antitumor and radiosensitizing effects
title_full	Interruption of lactate uptake by inhibiting mitochondrial pyruvate transport unravels direct antitumor and radiosensitizing effects
title_fullStr	Interruption of lactate uptake by inhibiting mitochondrial pyruvate transport unravels direct antitumor and radiosensitizing effects
title_full_unstemmed	Interruption of lactate uptake by inhibiting mitochondrial pyruvate transport unravels direct antitumor and radiosensitizing effects
title_sort	interruption of lactate uptake by inhibiting mitochondrial pyruvate transport unravels direct antitumor and radiosensitizing effects
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/11c35a245c4e4c128676d165835a54e9
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Interruption of lactate uptake by inhibiting mitochondrial pyruvate transport unravels direct antitumor and radiosensitizing effects

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