Synchronization within, and interactions between, the default mode and dorsal attention networks in relapsing-remitting multiple sclerosis

Muhua Huang,1,2 Fuqing Zhou,1,2 Lin Wu,1,2 Bo Wang,1,2 Hui Wan,3 Fangjun Li,3 Xianjun Zeng,1,2 Honghan Gong1,2 1Department of Radiology, The First Affiliated Hospital, Nanchang University, Nanchang, People’s Republic of China; 2Neuroradiology Laboratory, Jiangxi Province Medical Imaging R...

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Autores principales:	Huang M, Zhou F, Wu L, Wang B, Wan H, Li F, Zeng X, Gong H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	default mode network dorsal attention network multiple sclerosis resting-state functional MRI Granger causality test anticorrelation. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/11c513ae57d34dddbced0dc204ea1bf9
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spelling	oai:doaj.org-article:11c513ae57d34dddbced0dc204ea1bf92021-12-02T00:40:26ZSynchronization within, and interactions between, the default mode and dorsal attention networks in relapsing-remitting multiple sclerosis1178-2021https://doaj.org/article/11c513ae57d34dddbced0dc204ea1bf92018-05-01T00:00:00Zhttps://www.dovepress.com/synchronization-within-and-interactions-between-the-default-mode-and-d-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Muhua Huang,1,2 Fuqing Zhou,1,2 Lin Wu,1,2 Bo Wang,1,2 Hui Wan,3 Fangjun Li,3 Xianjun Zeng,1,2 Honghan Gong1,2 1Department of Radiology, The First Affiliated Hospital, Nanchang University, Nanchang, People’s Republic of China; 2Neuroradiology Laboratory, Jiangxi Province Medical Imaging Research Institute, Nanchang, People’s Republic of China; 3Department of Neurology, The First Affiliated Hospital, Nanchang University, Nanchang, People’s Republic of China Background and purpose: The effects of the interactions between the default mode network (DMN) and the dorsal attention network (DAN), which present anticorrelated behaviors, in relapsing-remitting multiple sclerosis (RRMS) are poorly understood. This study used resting-state functional connectivity (FC) and the Granger causality test (GCT) to examine changes in the undirected and effective functional network connectivity (FNC) between the two networks during the remitting phase in RRMS patients.Patients and methods: Thirty-three patients experiencing a clinically diagnosed remitting phase of RRMS and 33 well-matched healthy control subjects participated in this study. First, an independent component (IC) analysis was performed to preprocess the functional magnetic resonance imaging data and select resting-state networks. Then, an FNC analysis and the GCT were combined to examine the temporal correlations between the ICs of the DMN and DAN and to identify correlations with clinical markers.Results: Compared with the healthy subjects, the RRMS patients in the remitting phase showed the following: 1) significantly decreased FC within the DAN in the postcentral gyrus and decreased FC within the DMN in several regions except the parahippocampal gyrus, where increased FC was observed; 2) a relatively stable interaction between the two anticorrelated networks as well as a driving connectivity from the DAN to DMN (IC15); and 3) significantly positive correlations between the connectivity coefficient of the right superior temporal gyrus and the Modified Fatigue Impact Scale score (ρ = 0.379, p = 0.036).Conclusion: Adaptive mechanisms that maintain stable interactions might occur between the DMN and DAN during the remitting phase in RRMS patients. Keywords: default mode network, dorsal attention network, multiple sclerosis, resting-state functional MRI, Granger causality test, anticorrelationHuang MZhou FWu LWang BWan HLi FZeng XGong HDove Medical Pressarticledefault mode networkdorsal attention networkmultiple sclerosisresting-state functional MRIGranger causality testanticorrelation.Neurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 14, Pp 1241-1252 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	default mode network dorsal attention network multiple sclerosis resting-state functional MRI Granger causality test anticorrelation. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	default mode network dorsal attention network multiple sclerosis resting-state functional MRI Granger causality test anticorrelation. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Huang M Zhou F Wu L Wang B Wan H Li F Zeng X Gong H Synchronization within, and interactions between, the default mode and dorsal attention networks in relapsing-remitting multiple sclerosis
description	Muhua Huang,1,2 Fuqing Zhou,1,2 Lin Wu,1,2 Bo Wang,1,2 Hui Wan,3 Fangjun Li,3 Xianjun Zeng,1,2 Honghan Gong1,2 1Department of Radiology, The First Affiliated Hospital, Nanchang University, Nanchang, People’s Republic of China; 2Neuroradiology Laboratory, Jiangxi Province Medical Imaging Research Institute, Nanchang, People’s Republic of China; 3Department of Neurology, The First Affiliated Hospital, Nanchang University, Nanchang, People’s Republic of China Background and purpose: The effects of the interactions between the default mode network (DMN) and the dorsal attention network (DAN), which present anticorrelated behaviors, in relapsing-remitting multiple sclerosis (RRMS) are poorly understood. This study used resting-state functional connectivity (FC) and the Granger causality test (GCT) to examine changes in the undirected and effective functional network connectivity (FNC) between the two networks during the remitting phase in RRMS patients.Patients and methods: Thirty-three patients experiencing a clinically diagnosed remitting phase of RRMS and 33 well-matched healthy control subjects participated in this study. First, an independent component (IC) analysis was performed to preprocess the functional magnetic resonance imaging data and select resting-state networks. Then, an FNC analysis and the GCT were combined to examine the temporal correlations between the ICs of the DMN and DAN and to identify correlations with clinical markers.Results: Compared with the healthy subjects, the RRMS patients in the remitting phase showed the following: 1) significantly decreased FC within the DAN in the postcentral gyrus and decreased FC within the DMN in several regions except the parahippocampal gyrus, where increased FC was observed; 2) a relatively stable interaction between the two anticorrelated networks as well as a driving connectivity from the DAN to DMN (IC15); and 3) significantly positive correlations between the connectivity coefficient of the right superior temporal gyrus and the Modified Fatigue Impact Scale score (ρ = 0.379, p = 0.036).Conclusion: Adaptive mechanisms that maintain stable interactions might occur between the DMN and DAN during the remitting phase in RRMS patients. Keywords: default mode network, dorsal attention network, multiple sclerosis, resting-state functional MRI, Granger causality test, anticorrelation
format	article
author	Huang M Zhou F Wu L Wang B Wan H Li F Zeng X Gong H
author_facet	Huang M Zhou F Wu L Wang B Wan H Li F Zeng X Gong H
author_sort	Huang M
title	Synchronization within, and interactions between, the default mode and dorsal attention networks in relapsing-remitting multiple sclerosis
title_short	Synchronization within, and interactions between, the default mode and dorsal attention networks in relapsing-remitting multiple sclerosis
title_full	Synchronization within, and interactions between, the default mode and dorsal attention networks in relapsing-remitting multiple sclerosis
title_fullStr	Synchronization within, and interactions between, the default mode and dorsal attention networks in relapsing-remitting multiple sclerosis
title_full_unstemmed	Synchronization within, and interactions between, the default mode and dorsal attention networks in relapsing-remitting multiple sclerosis
title_sort	synchronization within, and interactions between, the default mode and dorsal attention networks in relapsing-remitting multiple sclerosis
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/11c513ae57d34dddbced0dc204ea1bf9
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Synchronization within, and interactions between, the default mode and dorsal attention networks in relapsing-remitting multiple sclerosis

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