Clinical and Laboratory Findings of Favism in Adults in Yahyanejad Hospital, Babol

BACKGROUND AND OBJECTIVE: Glucose 6-phosphate dehydrogenase (G6PD) deficiency is the most common enzymatic disorder of red blood cells in humans. G6PD deficiency is prevalent in Iran especially in north region. Considering that favism is one of the most reason of hospitalization of these patients, t...

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Autores principales:	M Saleki, SH Abedi, M Sharbatdaran
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2011
Materias:	favism glucose 6-phosphate dehydrogenase deficiency hemolysis Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/11cb996a2c994dfca04227e7ba0e3c33
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spelling	oai:doaj.org-article:11cb996a2c994dfca04227e7ba0e3c332021-11-10T08:56:19ZClinical and Laboratory Findings of Favism in Adults in Yahyanejad Hospital, Babol1561-41072251-7170https://doaj.org/article/11cb996a2c994dfca04227e7ba0e3c332011-02-01T00:00:00Zhttp://jbums.org/article-1-3721-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: Glucose 6-phosphate dehydrogenase (G6PD) deficiency is the most common enzymatic disorder of red blood cells in humans. G6PD deficiency is prevalent in Iran especially in north region. Considering that favism is one of the most reason of hospitalization of these patients, the aim of this study was to evaluate the clinical and laboratory findings of favism in adults, in north of Iran. METHODS: This cross-sectional study was performed on 50 adult patients with favism hospitalized in Babol city, north of Iran (2006-2008). Data on demographic and clinical features and laboratory findings, cause of hemolysis and blood transfusion were evaluated and then data was analyzed. FINDINGS: All of patients had exposure to fava beans. Twenty six (52%) were male and 24 (48%) were female. Thirty (60%) hadn experience of such attack. Clinical features were dark urine in 45 (90%), headache in 34 (68%), nausea in 28 (56%), stomach pain in 23 (46%), vomiting in 20 (40%) and fever in 8 (16%). Sclera was icteric in all patients. Bilirubinuria and hemoglobinuria were seen in 9 (18%) and 16 (32%), respectively. CONCLUSION: According to the findings of this study based on favism new onset in adults (60%), and no difference in gender distribution, future studies to evaluate causes of hemolysis due to fava bean in adults and relations with G6PD deficiency suggested. Also, the results show that in north of Iran in management of adults with icter or acute hemolytic anemia, favism should be considered (also in women).M SalekiSH AbediM SharbatdaranBabol University of Medical Sciencesarticlefavismglucose 6-phosphate dehydrogenase deficiencyhemolysisMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 13, Iss 1, Pp 70-75 (2011)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	favism glucose 6-phosphate dehydrogenase deficiency hemolysis Medicine R Medicine (General) R5-920
spellingShingle	favism glucose 6-phosphate dehydrogenase deficiency hemolysis Medicine R Medicine (General) R5-920 M Saleki SH Abedi M Sharbatdaran Clinical and Laboratory Findings of Favism in Adults in Yahyanejad Hospital, Babol
description	BACKGROUND AND OBJECTIVE: Glucose 6-phosphate dehydrogenase (G6PD) deficiency is the most common enzymatic disorder of red blood cells in humans. G6PD deficiency is prevalent in Iran especially in north region. Considering that favism is one of the most reason of hospitalization of these patients, the aim of this study was to evaluate the clinical and laboratory findings of favism in adults, in north of Iran. METHODS: This cross-sectional study was performed on 50 adult patients with favism hospitalized in Babol city, north of Iran (2006-2008). Data on demographic and clinical features and laboratory findings, cause of hemolysis and blood transfusion were evaluated and then data was analyzed. FINDINGS: All of patients had exposure to fava beans. Twenty six (52%) were male and 24 (48%) were female. Thirty (60%) hadn experience of such attack. Clinical features were dark urine in 45 (90%), headache in 34 (68%), nausea in 28 (56%), stomach pain in 23 (46%), vomiting in 20 (40%) and fever in 8 (16%). Sclera was icteric in all patients. Bilirubinuria and hemoglobinuria were seen in 9 (18%) and 16 (32%), respectively. CONCLUSION: According to the findings of this study based on favism new onset in adults (60%), and no difference in gender distribution, future studies to evaluate causes of hemolysis due to fava bean in adults and relations with G6PD deficiency suggested. Also, the results show that in north of Iran in management of adults with icter or acute hemolytic anemia, favism should be considered (also in women).
format	article
author	M Saleki SH Abedi M Sharbatdaran
author_facet	M Saleki SH Abedi M Sharbatdaran
author_sort	M Saleki
title	Clinical and Laboratory Findings of Favism in Adults in Yahyanejad Hospital, Babol
title_short	Clinical and Laboratory Findings of Favism in Adults in Yahyanejad Hospital, Babol
title_full	Clinical and Laboratory Findings of Favism in Adults in Yahyanejad Hospital, Babol
title_fullStr	Clinical and Laboratory Findings of Favism in Adults in Yahyanejad Hospital, Babol
title_full_unstemmed	Clinical and Laboratory Findings of Favism in Adults in Yahyanejad Hospital, Babol
title_sort	clinical and laboratory findings of favism in adults in yahyanejad hospital, babol
publisher	Babol University of Medical Sciences
publishDate	2011
url	https://doaj.org/article/11cb996a2c994dfca04227e7ba0e3c33
work_keys_str_mv	AT msaleki clinicalandlaboratoryfindingsoffavisminadultsinyahyanejadhospitalbabol AT shabedi clinicalandlaboratoryfindingsoffavisminadultsinyahyanejadhospitalbabol AT msharbatdaran clinicalandlaboratoryfindingsoffavisminadultsinyahyanejadhospitalbabol
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Clinical and Laboratory Findings of Favism in Adults in Yahyanejad Hospital, Babol

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