Thiazoline-related innate fear stimuli orchestrate hypothermia and anti-hypoxia via sensory TRPA1 activation

Matsuo et al. report that thiazoline-related innate fear-eliciting compounds activate the spinal trigeminal nucleus (Sp5) and the nucleus of the solitary tract (NTS) via vagal/trigeminal TRPA1 to induce robust physiological alterations, enabling long time survival in a lethal hypoxic environment.

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Autores principales:	Tomohiko Matsuo, Tomoko Isosaka, Yuichiro Hayashi, Lijun Tang, Akihiro Doi, Aiko Yasuda, Mikio Hayashi, Chia-Ying Lee, Liqin Cao, Natsumaro Kutsuna, Sachihiro Matsunaga, Takeshi Matsuda, Ikuko Yao, Mitsuyoshi Setou, Dai Kanagawa, Koichiro Higasa, Masahito Ikawa, Qinghua Liu, Reiko Kobayakawa, Ko Kobayakawa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/11cd2c695fc1408dbc40c83693c9f503
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spelling	oai:doaj.org-article:11cd2c695fc1408dbc40c83693c9f5032021-12-02T18:15:35ZThiazoline-related innate fear stimuli orchestrate hypothermia and anti-hypoxia via sensory TRPA1 activation10.1038/s41467-021-22205-02041-1723https://doaj.org/article/11cd2c695fc1408dbc40c83693c9f5032021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22205-0https://doaj.org/toc/2041-1723Matsuo et al. report that thiazoline-related innate fear-eliciting compounds activate the spinal trigeminal nucleus (Sp5) and the nucleus of the solitary tract (NTS) via vagal/trigeminal TRPA1 to induce robust physiological alterations, enabling long time survival in a lethal hypoxic environment.Tomohiko MatsuoTomoko IsosakaYuichiro HayashiLijun TangAkihiro DoiAiko YasudaMikio HayashiChia-Ying LeeLiqin CaoNatsumaro KutsunaSachihiro MatsunagaTakeshi MatsudaIkuko YaoMitsuyoshi SetouDai KanagawaKoichiro HigasaMasahito IkawaQinghua LiuReiko KobayakawaKo KobayakawaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tomohiko Matsuo Tomoko Isosaka Yuichiro Hayashi Lijun Tang Akihiro Doi Aiko Yasuda Mikio Hayashi Chia-Ying Lee Liqin Cao Natsumaro Kutsuna Sachihiro Matsunaga Takeshi Matsuda Ikuko Yao Mitsuyoshi Setou Dai Kanagawa Koichiro Higasa Masahito Ikawa Qinghua Liu Reiko Kobayakawa Ko Kobayakawa Thiazoline-related innate fear stimuli orchestrate hypothermia and anti-hypoxia via sensory TRPA1 activation
description	Matsuo et al. report that thiazoline-related innate fear-eliciting compounds activate the spinal trigeminal nucleus (Sp5) and the nucleus of the solitary tract (NTS) via vagal/trigeminal TRPA1 to induce robust physiological alterations, enabling long time survival in a lethal hypoxic environment.
format	article
author	Tomohiko Matsuo Tomoko Isosaka Yuichiro Hayashi Lijun Tang Akihiro Doi Aiko Yasuda Mikio Hayashi Chia-Ying Lee Liqin Cao Natsumaro Kutsuna Sachihiro Matsunaga Takeshi Matsuda Ikuko Yao Mitsuyoshi Setou Dai Kanagawa Koichiro Higasa Masahito Ikawa Qinghua Liu Reiko Kobayakawa Ko Kobayakawa
author_facet	Tomohiko Matsuo Tomoko Isosaka Yuichiro Hayashi Lijun Tang Akihiro Doi Aiko Yasuda Mikio Hayashi Chia-Ying Lee Liqin Cao Natsumaro Kutsuna Sachihiro Matsunaga Takeshi Matsuda Ikuko Yao Mitsuyoshi Setou Dai Kanagawa Koichiro Higasa Masahito Ikawa Qinghua Liu Reiko Kobayakawa Ko Kobayakawa
author_sort	Tomohiko Matsuo
title	Thiazoline-related innate fear stimuli orchestrate hypothermia and anti-hypoxia via sensory TRPA1 activation
title_short	Thiazoline-related innate fear stimuli orchestrate hypothermia and anti-hypoxia via sensory TRPA1 activation
title_full	Thiazoline-related innate fear stimuli orchestrate hypothermia and anti-hypoxia via sensory TRPA1 activation
title_fullStr	Thiazoline-related innate fear stimuli orchestrate hypothermia and anti-hypoxia via sensory TRPA1 activation
title_full_unstemmed	Thiazoline-related innate fear stimuli orchestrate hypothermia and anti-hypoxia via sensory TRPA1 activation
title_sort	thiazoline-related innate fear stimuli orchestrate hypothermia and anti-hypoxia via sensory trpa1 activation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/11cd2c695fc1408dbc40c83693c9f503
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Thiazoline-related innate fear stimuli orchestrate hypothermia and anti-hypoxia via sensory TRPA1 activation

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