Tapping into 5-HT<sub>3</sub> Receptors to Modify Metabolic and Immune Responses
5-hydroxytryptamine type 3 (5-HT<sub>3</sub>) receptors are ligand gated ion channels, which clearly distinguish their mode of action from the other G-protein coupled 5-HT or serotonin receptors. 5-HT<sub>3</sub> receptors are well established targets for emesis and gastroint...
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2021
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oai:doaj.org-article:11cf03c808e84298896f72a6333f1c2d2021-11-11T17:19:28ZTapping into 5-HT<sub>3</sub> Receptors to Modify Metabolic and Immune Responses10.3390/ijms2221119101422-00671661-6596https://doaj.org/article/11cf03c808e84298896f72a6333f1c2d2021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11910https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-00675-hydroxytryptamine type 3 (5-HT<sub>3</sub>) receptors are ligand gated ion channels, which clearly distinguish their mode of action from the other G-protein coupled 5-HT or serotonin receptors. 5-HT<sub>3</sub> receptors are well established targets for emesis and gastrointestinal mobility and are used as adjunct targets in treating schizophrenia. However, the distribution of these receptors is wider than the nervous system and there is potential that these additional sites can be targeted to modulate inflammatory and/or metabolic conditions. Recent progress in structural biology and pharmacology of 5-HT<sub>3</sub> receptors have provided profound insights into mechanisms of their action. These advances, combined with insights into clinical relevance of mutations in genes encoding 5-HT<sub>3</sub> subunits and increasing understanding of their implications in patient’s predisposition to diseases and response to the treatment, open new avenues for personalized precision medicine. In this review, we recap on the current status of 5-HT<sub>3</sub> receptor-based therapies using a biochemical and physiological perspective. We assess the potential for targeting 5-HT<sub>3</sub> receptors in conditions involving metabolic or inflammatory disorders based on recent findings, underscoring the challenges and limitations of this approach.Helen IrvingIlona TurekChristine KettleNor YaakobMDPI AGarticleserotonin receptors5-hydroxytryptamine receptorsmetabolismadipose tissuechemotherapy induced vomiting and emesis (CINV)inflammationBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11910, p 11910 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
serotonin receptors 5-hydroxytryptamine receptors metabolism adipose tissue chemotherapy induced vomiting and emesis (CINV) inflammation Biology (General) QH301-705.5 Chemistry QD1-999 |
| spellingShingle |
serotonin receptors 5-hydroxytryptamine receptors metabolism adipose tissue chemotherapy induced vomiting and emesis (CINV) inflammation Biology (General) QH301-705.5 Chemistry QD1-999 Helen Irving Ilona Turek Christine Kettle Nor Yaakob Tapping into 5-HT<sub>3</sub> Receptors to Modify Metabolic and Immune Responses |
| description |
5-hydroxytryptamine type 3 (5-HT<sub>3</sub>) receptors are ligand gated ion channels, which clearly distinguish their mode of action from the other G-protein coupled 5-HT or serotonin receptors. 5-HT<sub>3</sub> receptors are well established targets for emesis and gastrointestinal mobility and are used as adjunct targets in treating schizophrenia. However, the distribution of these receptors is wider than the nervous system and there is potential that these additional sites can be targeted to modulate inflammatory and/or metabolic conditions. Recent progress in structural biology and pharmacology of 5-HT<sub>3</sub> receptors have provided profound insights into mechanisms of their action. These advances, combined with insights into clinical relevance of mutations in genes encoding 5-HT<sub>3</sub> subunits and increasing understanding of their implications in patient’s predisposition to diseases and response to the treatment, open new avenues for personalized precision medicine. In this review, we recap on the current status of 5-HT<sub>3</sub> receptor-based therapies using a biochemical and physiological perspective. We assess the potential for targeting 5-HT<sub>3</sub> receptors in conditions involving metabolic or inflammatory disorders based on recent findings, underscoring the challenges and limitations of this approach. |
| format |
article |
| author |
Helen Irving Ilona Turek Christine Kettle Nor Yaakob |
| author_facet |
Helen Irving Ilona Turek Christine Kettle Nor Yaakob |
| author_sort |
Helen Irving |
| title |
Tapping into 5-HT<sub>3</sub> Receptors to Modify Metabolic and Immune Responses |
| title_short |
Tapping into 5-HT<sub>3</sub> Receptors to Modify Metabolic and Immune Responses |
| title_full |
Tapping into 5-HT<sub>3</sub> Receptors to Modify Metabolic and Immune Responses |
| title_fullStr |
Tapping into 5-HT<sub>3</sub> Receptors to Modify Metabolic and Immune Responses |
| title_full_unstemmed |
Tapping into 5-HT<sub>3</sub> Receptors to Modify Metabolic and Immune Responses |
| title_sort |
tapping into 5-ht<sub>3</sub> receptors to modify metabolic and immune responses |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/11cf03c808e84298896f72a6333f1c2d |
| work_keys_str_mv |
AT helenirving tappinginto5htsub3subreceptorstomodifymetabolicandimmuneresponses AT ilonaturek tappinginto5htsub3subreceptorstomodifymetabolicandimmuneresponses AT christinekettle tappinginto5htsub3subreceptorstomodifymetabolicandimmuneresponses AT noryaakob tappinginto5htsub3subreceptorstomodifymetabolicandimmuneresponses |
| _version_ |
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