Involvement of serotonergic, noradrenergic and gabaergic systems in the antinociceptive effect of a ketamine-magnesium sulfate combination in acute pain

Ketamine and magnesium can interact in additive, supra-additive and antagonistic manners in analgesia or anesthesia. Ketamine is a non-competitive NMDA receptor antagonist. Magnesium is an endogenous non-competitive NMDA antagonist that causes anion channel blockade in a dose-dependent manner. It ha...

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Autores principales:	Katarina Savić Vujović, Sonja Vučković, Radan Stojanović, Nevena Divac, Branislava Medić, Dragana Srebro, Marko Kadija, Milica Prostran
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2018
Materias:	analgesia bicuculline ketamine magnesium methysergide yohimbine Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/11d13ed62e564f5686e80cfbac7114fc
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spelling	oai:doaj.org-article:11d13ed62e564f5686e80cfbac7114fc2021-11-17T21:27:52ZInvolvement of serotonergic, noradrenergic and gabaergic systems in the antinociceptive effect of a ketamine-magnesium sulfate combination in acute pain1820-744810.2478/acve-2018-0009https://doaj.org/article/11d13ed62e564f5686e80cfbac7114fc2018-03-01T00:00:00Zhttps://doi.org/10.2478/acve-2018-0009https://doaj.org/toc/1820-7448Ketamine and magnesium can interact in additive, supra-additive and antagonistic manners in analgesia or anesthesia. Ketamine is a non-competitive NMDA receptor antagonist. Magnesium is an endogenous non-competitive NMDA antagonist that causes anion channel blockade in a dose-dependent manner. It has been established that ketamine and magnesium interact synergistically in the tail-immersion test in rats.Katarina Savić VujovićSonja VučkovićRadan StojanovićNevena DivacBranislava MedićDragana SrebroMarko KadijaMilica ProstranSciendoarticleanalgesiabicucullineketaminemagnesiummethysergideyohimbineVeterinary medicineSF600-1100ENActa Veterinaria, Vol 68, Iss 1, Pp 108-118 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	analgesia bicuculline ketamine magnesium methysergide yohimbine Veterinary medicine SF600-1100
spellingShingle	analgesia bicuculline ketamine magnesium methysergide yohimbine Veterinary medicine SF600-1100 Katarina Savić Vujović Sonja Vučković Radan Stojanović Nevena Divac Branislava Medić Dragana Srebro Marko Kadija Milica Prostran Involvement of serotonergic, noradrenergic and gabaergic systems in the antinociceptive effect of a ketamine-magnesium sulfate combination in acute pain
description	Ketamine and magnesium can interact in additive, supra-additive and antagonistic manners in analgesia or anesthesia. Ketamine is a non-competitive NMDA receptor antagonist. Magnesium is an endogenous non-competitive NMDA antagonist that causes anion channel blockade in a dose-dependent manner. It has been established that ketamine and magnesium interact synergistically in the tail-immersion test in rats.
format	article
author	Katarina Savić Vujović Sonja Vučković Radan Stojanović Nevena Divac Branislava Medić Dragana Srebro Marko Kadija Milica Prostran
author_facet	Katarina Savić Vujović Sonja Vučković Radan Stojanović Nevena Divac Branislava Medić Dragana Srebro Marko Kadija Milica Prostran
author_sort	Katarina Savić Vujović
title	Involvement of serotonergic, noradrenergic and gabaergic systems in the antinociceptive effect of a ketamine-magnesium sulfate combination in acute pain
title_short	Involvement of serotonergic, noradrenergic and gabaergic systems in the antinociceptive effect of a ketamine-magnesium sulfate combination in acute pain
title_full	Involvement of serotonergic, noradrenergic and gabaergic systems in the antinociceptive effect of a ketamine-magnesium sulfate combination in acute pain
title_fullStr	Involvement of serotonergic, noradrenergic and gabaergic systems in the antinociceptive effect of a ketamine-magnesium sulfate combination in acute pain
title_full_unstemmed	Involvement of serotonergic, noradrenergic and gabaergic systems in the antinociceptive effect of a ketamine-magnesium sulfate combination in acute pain
title_sort	involvement of serotonergic, noradrenergic and gabaergic systems in the antinociceptive effect of a ketamine-magnesium sulfate combination in acute pain
publisher	Sciendo
publishDate	2018
url	https://doaj.org/article/11d13ed62e564f5686e80cfbac7114fc
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Involvement of serotonergic, noradrenergic and gabaergic systems in the antinociceptive effect of a ketamine-magnesium sulfate combination in acute pain

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