Analysis of Polybrominated Diphenyl Ethers and Lipid Composition in Human Breast Milk and Their Correlation with Infant Neurodevelopment

Breastfeeding is recommended over formula feeding, but human breast milk (HBM) composition varies and can be affected by food additives. Whether flame-retardant polybrominated diphenyl ethers (PBDEs) found in HBM interact with lipid components of HBM to impede infant neurodevelopment is a critical p...

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Autores principales:	Ming-Hsien Tsai, How-Ran Chao, Wen-Li Hsu, Ching-Chung Tsai, Chu-Wen Lin, Chu-Huang Chen
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	infant neurodevelopment polybrominated diphenyl ethers lipid fatty acid lipidomics Medicine R
Acceso en línea:	https://doaj.org/article/11d2036ffdd24d948c5aed543c7712ad
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spelling	oai:doaj.org-article:11d2036ffdd24d948c5aed543c7712ad2021-11-11T16:37:28ZAnalysis of Polybrominated Diphenyl Ethers and Lipid Composition in Human Breast Milk and Their Correlation with Infant Neurodevelopment10.3390/ijerph1821115011660-46011661-7827https://doaj.org/article/11d2036ffdd24d948c5aed543c7712ad2021-11-01T00:00:00Zhttps://www.mdpi.com/1660-4601/18/21/11501https://doaj.org/toc/1661-7827https://doaj.org/toc/1660-4601Breastfeeding is recommended over formula feeding, but human breast milk (HBM) composition varies and can be affected by food additives. Whether flame-retardant polybrominated diphenyl ethers (PBDEs) found in HBM interact with lipid components of HBM to impede infant neurodevelopment is a critical public health issue. Using lipidomic analysis, we examined the association of PBDEs in HBM and HBM lipid components with infant neurodevelopment. HBM samples (n = 100) were collected at the beginning stage of breastfeeding and analyzed for 30 PBDE congeners as well as a group of lipid components by using high-resolution gas chromatography, mass spectrometry, and liquid chromatography time-of-flight mass spectrometry. Infants were examined at 8 to 12 months of age by using the Bayley-III to assess neurodevelopment. A total of seven PBDEs, 35 lipids, and 27 fatty acids in HBM showed significant associations with Bayley-III scores. Multivariate analysis confirmed that these candidate PBDEs and lipid components were significant predictors of infant neurodevelopment. Eicosapentaenoic acid and docosapentaenoic acid in HBM showed no association with infant neurodevelopment in the general Taiwanese population. While certain PBDEs may play a role, our findings indicate that the lipid components of HBM are directly important for infant neurodevelopment.Ming-Hsien TsaiHow-Ran ChaoWen-Li HsuChing-Chung TsaiChu-Wen LinChu-Huang ChenMDPI AGarticleinfant neurodevelopmentpolybrominated diphenyl etherslipidfatty acidlipidomicsMedicineRENInternational Journal of Environmental Research and Public Health, Vol 18, Iss 11501, p 11501 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	infant neurodevelopment polybrominated diphenyl ethers lipid fatty acid lipidomics Medicine R
spellingShingle	infant neurodevelopment polybrominated diphenyl ethers lipid fatty acid lipidomics Medicine R Ming-Hsien Tsai How-Ran Chao Wen-Li Hsu Ching-Chung Tsai Chu-Wen Lin Chu-Huang Chen Analysis of Polybrominated Diphenyl Ethers and Lipid Composition in Human Breast Milk and Their Correlation with Infant Neurodevelopment
description	Breastfeeding is recommended over formula feeding, but human breast milk (HBM) composition varies and can be affected by food additives. Whether flame-retardant polybrominated diphenyl ethers (PBDEs) found in HBM interact with lipid components of HBM to impede infant neurodevelopment is a critical public health issue. Using lipidomic analysis, we examined the association of PBDEs in HBM and HBM lipid components with infant neurodevelopment. HBM samples (n = 100) were collected at the beginning stage of breastfeeding and analyzed for 30 PBDE congeners as well as a group of lipid components by using high-resolution gas chromatography, mass spectrometry, and liquid chromatography time-of-flight mass spectrometry. Infants were examined at 8 to 12 months of age by using the Bayley-III to assess neurodevelopment. A total of seven PBDEs, 35 lipids, and 27 fatty acids in HBM showed significant associations with Bayley-III scores. Multivariate analysis confirmed that these candidate PBDEs and lipid components were significant predictors of infant neurodevelopment. Eicosapentaenoic acid and docosapentaenoic acid in HBM showed no association with infant neurodevelopment in the general Taiwanese population. While certain PBDEs may play a role, our findings indicate that the lipid components of HBM are directly important for infant neurodevelopment.
format	article
author	Ming-Hsien Tsai How-Ran Chao Wen-Li Hsu Ching-Chung Tsai Chu-Wen Lin Chu-Huang Chen
author_facet	Ming-Hsien Tsai How-Ran Chao Wen-Li Hsu Ching-Chung Tsai Chu-Wen Lin Chu-Huang Chen
author_sort	Ming-Hsien Tsai
title	Analysis of Polybrominated Diphenyl Ethers and Lipid Composition in Human Breast Milk and Their Correlation with Infant Neurodevelopment
title_short	Analysis of Polybrominated Diphenyl Ethers and Lipid Composition in Human Breast Milk and Their Correlation with Infant Neurodevelopment
title_full	Analysis of Polybrominated Diphenyl Ethers and Lipid Composition in Human Breast Milk and Their Correlation with Infant Neurodevelopment
title_fullStr	Analysis of Polybrominated Diphenyl Ethers and Lipid Composition in Human Breast Milk and Their Correlation with Infant Neurodevelopment
title_full_unstemmed	Analysis of Polybrominated Diphenyl Ethers and Lipid Composition in Human Breast Milk and Their Correlation with Infant Neurodevelopment
title_sort	analysis of polybrominated diphenyl ethers and lipid composition in human breast milk and their correlation with infant neurodevelopment
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/11d2036ffdd24d948c5aed543c7712ad
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Analysis of Polybrominated Diphenyl Ethers and Lipid Composition in Human Breast Milk and Their Correlation with Infant Neurodevelopment

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