Short Communication: Phytochemical diversity and bioactivity of Malaysian Premna cordifolia (Lamiaceae)

Abstract. Daud D, Dewa MSAM, Mahbob ENM, Razak WRWA. 2021. Short Communication: Phytochemical diversity and bioactivity of Malaysian Premna cordifolia (Lamiaceae). Biodiversitas 22: 3245-3248. The aims of the present study are to determine the chelation potential and protective effect of Premna cord...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	DZULSUHAIMI DAUD, MUHAMMAD SHAFIQ AZAMUDIN MD DEWA, EMI NORZEHAN MOHAMAD MAHBOB, WAN RAZARINAH WAN ABDUL RAZAK
Formato:	article
Lenguaje:	EN
Publicado:	MBI & UNS Solo 2021
Materias:	chelation activity lead phytochemicals premna cordifolia repro-toxicology Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/11d61f22c7ad49288635ed752b2b1017
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:11d61f22c7ad49288635ed752b2b1017
record_format	dspace
spelling	oai:doaj.org-article:11d61f22c7ad49288635ed752b2b10172021-11-22T12:14:18ZShort Communication: Phytochemical diversity and bioactivity of Malaysian Premna cordifolia (Lamiaceae)1412-033X2085-472210.13057/biodiv/d220628https://doaj.org/article/11d61f22c7ad49288635ed752b2b10172021-05-01T00:00:00Zhttps://smujo.id/biodiv/article/view/7841https://doaj.org/toc/1412-033Xhttps://doaj.org/toc/2085-4722Abstract. Daud D, Dewa MSAM, Mahbob ENM, Razak WRWA. 2021. Short Communication: Phytochemical diversity and bioactivity of Malaysian Premna cordifolia (Lamiaceae). Biodiversitas 22: 3245-3248. The aims of the present study are to determine the chelation potential and protective effect of Premna cordifolia leaves ethanolic extract in lead intoxicated mice. Twenty-four male mice were divided into four groups with six animals each. Group 1 was healthy mice and received 2 ml/kg bwt distilled water. Group 2 was healthy mice and supplemented with 200 mg/kg bwt P. cordifolia leaves ethanolic extract. Group 3 was lead intoxicated mice and received 2 ml/kg bwt distilled water. Group 4 was lead intoxicated mice and supplemented with 200 mg/kg bwt P. cordifolia leaves ethanolic extract. All treatments were given for 14 days. Chelation activity was determined by measuring the concentrations of lead in the liver, kidney and testis by using atomic absorption spectroscopy. Sperm quality was tested according to World Health Organization manual and testosterone was estimated by using ELISA kit. Spectroscopic data showed that P. cordifolia leaves ethanolic extract was able to lower lead concentrations in liver, kidney and testis of lead intoxicated mice. Following a decrease in lead concentrations, sperm quality and testosterone levels were restored in lead intoxicated mice supplemented with P. cordifolia leaves ethanolic extract. In conclusion, P. cordifolia leaves ethanolic extract has the potential to be developed as an alternative remedy for treating lead poisoning effects.DZULSUHAIMI DAUDMUHAMMAD SHAFIQ AZAMUDIN MD DEWAEMI NORZEHAN MOHAMAD MAHBOBWAN RAZARINAH WAN ABDUL RAZAKMBI & UNS Soloarticlechelation activityleadphytochemicalspremna cordifoliarepro-toxicologyBiology (General)QH301-705.5ENBiodiversitas, Vol 22, Iss 6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	chelation activity lead phytochemicals premna cordifolia repro-toxicology Biology (General) QH301-705.5
spellingShingle	chelation activity lead phytochemicals premna cordifolia repro-toxicology Biology (General) QH301-705.5 DZULSUHAIMI DAUD MUHAMMAD SHAFIQ AZAMUDIN MD DEWA EMI NORZEHAN MOHAMAD MAHBOB WAN RAZARINAH WAN ABDUL RAZAK Short Communication: Phytochemical diversity and bioactivity of Malaysian Premna cordifolia (Lamiaceae)
description	Abstract. Daud D, Dewa MSAM, Mahbob ENM, Razak WRWA. 2021. Short Communication: Phytochemical diversity and bioactivity of Malaysian Premna cordifolia (Lamiaceae). Biodiversitas 22: 3245-3248. The aims of the present study are to determine the chelation potential and protective effect of Premna cordifolia leaves ethanolic extract in lead intoxicated mice. Twenty-four male mice were divided into four groups with six animals each. Group 1 was healthy mice and received 2 ml/kg bwt distilled water. Group 2 was healthy mice and supplemented with 200 mg/kg bwt P. cordifolia leaves ethanolic extract. Group 3 was lead intoxicated mice and received 2 ml/kg bwt distilled water. Group 4 was lead intoxicated mice and supplemented with 200 mg/kg bwt P. cordifolia leaves ethanolic extract. All treatments were given for 14 days. Chelation activity was determined by measuring the concentrations of lead in the liver, kidney and testis by using atomic absorption spectroscopy. Sperm quality was tested according to World Health Organization manual and testosterone was estimated by using ELISA kit. Spectroscopic data showed that P. cordifolia leaves ethanolic extract was able to lower lead concentrations in liver, kidney and testis of lead intoxicated mice. Following a decrease in lead concentrations, sperm quality and testosterone levels were restored in lead intoxicated mice supplemented with P. cordifolia leaves ethanolic extract. In conclusion, P. cordifolia leaves ethanolic extract has the potential to be developed as an alternative remedy for treating lead poisoning effects.
format	article
author	DZULSUHAIMI DAUD MUHAMMAD SHAFIQ AZAMUDIN MD DEWA EMI NORZEHAN MOHAMAD MAHBOB WAN RAZARINAH WAN ABDUL RAZAK
author_facet	DZULSUHAIMI DAUD MUHAMMAD SHAFIQ AZAMUDIN MD DEWA EMI NORZEHAN MOHAMAD MAHBOB WAN RAZARINAH WAN ABDUL RAZAK
author_sort	DZULSUHAIMI DAUD
title	Short Communication: Phytochemical diversity and bioactivity of Malaysian Premna cordifolia (Lamiaceae)
title_short	Short Communication: Phytochemical diversity and bioactivity of Malaysian Premna cordifolia (Lamiaceae)
title_full	Short Communication: Phytochemical diversity and bioactivity of Malaysian Premna cordifolia (Lamiaceae)
title_fullStr	Short Communication: Phytochemical diversity and bioactivity of Malaysian Premna cordifolia (Lamiaceae)
title_full_unstemmed	Short Communication: Phytochemical diversity and bioactivity of Malaysian Premna cordifolia (Lamiaceae)
title_sort	short communication: phytochemical diversity and bioactivity of malaysian premna cordifolia (lamiaceae)
publisher	MBI & UNS Solo
publishDate	2021
url	https://doaj.org/article/11d61f22c7ad49288635ed752b2b1017
work_keys_str_mv	AT dzulsuhaimidaud shortcommunicationphytochemicaldiversityandbioactivityofmalaysianpremnacordifolialamiaceae AT muhammadshafiqazamudinmddewa shortcommunicationphytochemicaldiversityandbioactivityofmalaysianpremnacordifolialamiaceae AT eminorzehanmohamadmahbob shortcommunicationphytochemicaldiversityandbioactivityofmalaysianpremnacordifolialamiaceae AT wanrazarinahwanabdulrazak shortcommunicationphytochemicaldiversityandbioactivityofmalaysianpremnacordifolialamiaceae
_version_	1718417659919335424

Short Communication: Phytochemical diversity and bioactivity of Malaysian Premna cordifolia (Lamiaceae)

Ejemplares similares