Active prosthesis dependent functional cortical reorganization following stroke

Abstract The present study investigated the neural correlates associated with gait improvements triggered by an active prosthesis in patients with drop-foot following stroke during the chronic stage. Eleven patients took part in the study. MEG recordings in conjunction with somatosensory stimulation...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Christian Merkel, Janet Hausmann, Jens-Max Hopf, Hans-Jochen Heinze, Lars Buentjen, Mircea Ariel Schoenfeld
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/11dd08e63a6d4f0494d9062ce315ca3f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:11dd08e63a6d4f0494d9062ce315ca3f
record_format	dspace
spelling	oai:doaj.org-article:11dd08e63a6d4f0494d9062ce315ca3f2021-12-02T11:52:16ZActive prosthesis dependent functional cortical reorganization following stroke10.1038/s41598-017-09325-82045-2322https://doaj.org/article/11dd08e63a6d4f0494d9062ce315ca3f2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-09325-8https://doaj.org/toc/2045-2322Abstract The present study investigated the neural correlates associated with gait improvements triggered by an active prosthesis in patients with drop-foot following stroke during the chronic stage. Eleven patients took part in the study. MEG recordings in conjunction with somatosensory stimulation of the left and right hand as well as gait analyses were performed shortly before or after prosthesis implantation surgery and 3–4 months later. Plastic changes of the sensorimotor cortex of the ipsi- and contralesional hemisphere were revealed. Gait analysis indicated that all patients improved their gait with the active prosthesis. Patients with larger plastic changes within the lesioned hemisphere maintained their improved gait performance even when the prosthesis was turned off. Patients with larger contralesional changes also improved their gait with the active prosthesis. However, their gait measures decreased when the prosthesis was turned off. The current data provide the neural basis of gait improvement triggered by an active prosthesis and has important implications with respect to the choice of the type of active prosthesis (implantable vs removable) and to the selection procedure of the patients (length of testing period).Christian MerkelJanet HausmannJens-Max HopfHans-Jochen HeinzeLars BuentjenMircea Ariel SchoenfeldNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Christian Merkel Janet Hausmann Jens-Max Hopf Hans-Jochen Heinze Lars Buentjen Mircea Ariel Schoenfeld Active prosthesis dependent functional cortical reorganization following stroke
description	Abstract The present study investigated the neural correlates associated with gait improvements triggered by an active prosthesis in patients with drop-foot following stroke during the chronic stage. Eleven patients took part in the study. MEG recordings in conjunction with somatosensory stimulation of the left and right hand as well as gait analyses were performed shortly before or after prosthesis implantation surgery and 3–4 months later. Plastic changes of the sensorimotor cortex of the ipsi- and contralesional hemisphere were revealed. Gait analysis indicated that all patients improved their gait with the active prosthesis. Patients with larger plastic changes within the lesioned hemisphere maintained their improved gait performance even when the prosthesis was turned off. Patients with larger contralesional changes also improved their gait with the active prosthesis. However, their gait measures decreased when the prosthesis was turned off. The current data provide the neural basis of gait improvement triggered by an active prosthesis and has important implications with respect to the choice of the type of active prosthesis (implantable vs removable) and to the selection procedure of the patients (length of testing period).
format	article
author	Christian Merkel Janet Hausmann Jens-Max Hopf Hans-Jochen Heinze Lars Buentjen Mircea Ariel Schoenfeld
author_facet	Christian Merkel Janet Hausmann Jens-Max Hopf Hans-Jochen Heinze Lars Buentjen Mircea Ariel Schoenfeld
author_sort	Christian Merkel
title	Active prosthesis dependent functional cortical reorganization following stroke
title_short	Active prosthesis dependent functional cortical reorganization following stroke
title_full	Active prosthesis dependent functional cortical reorganization following stroke
title_fullStr	Active prosthesis dependent functional cortical reorganization following stroke
title_full_unstemmed	Active prosthesis dependent functional cortical reorganization following stroke
title_sort	active prosthesis dependent functional cortical reorganization following stroke
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/11dd08e63a6d4f0494d9062ce315ca3f
work_keys_str_mv	AT christianmerkel activeprosthesisdependentfunctionalcorticalreorganizationfollowingstroke AT janethausmann activeprosthesisdependentfunctionalcorticalreorganizationfollowingstroke AT jensmaxhopf activeprosthesisdependentfunctionalcorticalreorganizationfollowingstroke AT hansjochenheinze activeprosthesisdependentfunctionalcorticalreorganizationfollowingstroke AT larsbuentjen activeprosthesisdependentfunctionalcorticalreorganizationfollowingstroke AT mirceaarielschoenfeld activeprosthesisdependentfunctionalcorticalreorganizationfollowingstroke
_version_	1718395087991341056

Active prosthesis dependent functional cortical reorganization following stroke

Ejemplares similares