Changes of body mass index in relation to mortality: results of a cohort of 42,099 adults.

<h4>Background</h4>High Body-Mass-Index (BMI) is associated with increased all-cause mortality, but little is known about the effect of short- and long-term BMI change on mortality. The aim of the study was to determine how long-term weight change affects mortality.<h4>Methods and...

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Autores principales:	Jochen Klenk, Kilian Rapp, Hanno Ulmer, Hans Concin, Gabriele Nagel
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/11dea15d22b8492796547ccbde05eb25
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spelling	oai:doaj.org-article:11dea15d22b8492796547ccbde05eb252021-11-18T08:38:29ZChanges of body mass index in relation to mortality: results of a cohort of 42,099 adults.1932-620310.1371/journal.pone.0084817https://doaj.org/article/11dea15d22b8492796547ccbde05eb252014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24416291/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>High Body-Mass-Index (BMI) is associated with increased all-cause mortality, but little is known about the effect of short- and long-term BMI change on mortality. The aim of the study was to determine how long-term weight change affects mortality.<h4>Methods and findings</h4>Within a population-based prospective cohort of 42,099 Austrian men and women (mean age 43 years) with at least three BMI measurements we investigated the relationship of BMI at baseline and two subsequent BMI change intervals of five years each with all-cause mortality using Cox proportional Hazard models. During median follow-up of 12 years 4,119 deaths were identified. The lowest mortalities were found in persons with normal weight or overweight at baseline and stable BMI over 10 years. Weight gain (≥0.10 kg/m(2)/year) during the first five years was associated with increased mortality in overweight and obese people. For weight gain during both time intervals mortality risk remained significantly increased only in overweight (Hazard Ratio (HR): 1.39 (95% confidence interval: 1.01; 1.92)) and obese women (1.85 (95% confidence interval: 1.18; 2.89)). Weight loss (< -0.10 kg/m(2)/year) increased all-cause mortality in men and women consistently. BMI change over time assessed using accepted World Health Organisation BMI categories showed no increased mortality risk for people who remained in the normal or overweight category for all three measurements. In contrast, HRs for stable obese men and women were 1.57 (95% CI: 1.31; 1.87) and 1.46 (95% CI: 1.25; 1.71) respectively.<h4>Conclusion</h4>Our findings highlight the importance of weight stability and obesity avoidance in prevention strategy.Jochen KlenkKilian RappHanno UlmerHans ConcinGabriele NagelPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 1, p e84817 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jochen Klenk Kilian Rapp Hanno Ulmer Hans Concin Gabriele Nagel Changes of body mass index in relation to mortality: results of a cohort of 42,099 adults.
description	<h4>Background</h4>High Body-Mass-Index (BMI) is associated with increased all-cause mortality, but little is known about the effect of short- and long-term BMI change on mortality. The aim of the study was to determine how long-term weight change affects mortality.<h4>Methods and findings</h4>Within a population-based prospective cohort of 42,099 Austrian men and women (mean age 43 years) with at least three BMI measurements we investigated the relationship of BMI at baseline and two subsequent BMI change intervals of five years each with all-cause mortality using Cox proportional Hazard models. During median follow-up of 12 years 4,119 deaths were identified. The lowest mortalities were found in persons with normal weight or overweight at baseline and stable BMI over 10 years. Weight gain (≥0.10 kg/m(2)/year) during the first five years was associated with increased mortality in overweight and obese people. For weight gain during both time intervals mortality risk remained significantly increased only in overweight (Hazard Ratio (HR): 1.39 (95% confidence interval: 1.01; 1.92)) and obese women (1.85 (95% confidence interval: 1.18; 2.89)). Weight loss (< -0.10 kg/m(2)/year) increased all-cause mortality in men and women consistently. BMI change over time assessed using accepted World Health Organisation BMI categories showed no increased mortality risk for people who remained in the normal or overweight category for all three measurements. In contrast, HRs for stable obese men and women were 1.57 (95% CI: 1.31; 1.87) and 1.46 (95% CI: 1.25; 1.71) respectively.<h4>Conclusion</h4>Our findings highlight the importance of weight stability and obesity avoidance in prevention strategy.
format	article
author	Jochen Klenk Kilian Rapp Hanno Ulmer Hans Concin Gabriele Nagel
author_facet	Jochen Klenk Kilian Rapp Hanno Ulmer Hans Concin Gabriele Nagel
author_sort	Jochen Klenk
title	Changes of body mass index in relation to mortality: results of a cohort of 42,099 adults.
title_short	Changes of body mass index in relation to mortality: results of a cohort of 42,099 adults.
title_full	Changes of body mass index in relation to mortality: results of a cohort of 42,099 adults.
title_fullStr	Changes of body mass index in relation to mortality: results of a cohort of 42,099 adults.
title_full_unstemmed	Changes of body mass index in relation to mortality: results of a cohort of 42,099 adults.
title_sort	changes of body mass index in relation to mortality: results of a cohort of 42,099 adults.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/11dea15d22b8492796547ccbde05eb25
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Changes of body mass index in relation to mortality: results of a cohort of 42,099 adults.

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