A non-invasive magnetic resonance imaging approach for assessment of real-time microcirculation dynamics

Abstract We present a novel, non-invasive magnetic resonance imaging (MRI) technique to assess real-time dynamic vasomodulation of the microvascular bed. Unlike existing perfusion imaging techniques, our method is sensitive only to blood volume and not flow velocity. Using graded gas challenges and...

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Autores principales:	Tameshwar Ganesh, Marvin Estrada, Herman Yeger, James Duffin, Hai-Ling Margaret Cheng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/11e34cd5acd44e7cb5c9513b6c45a13c
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spelling	oai:doaj.org-article:11e34cd5acd44e7cb5c9513b6c45a13c2021-12-02T11:52:27ZA non-invasive magnetic resonance imaging approach for assessment of real-time microcirculation dynamics10.1038/s41598-017-06983-62045-2322https://doaj.org/article/11e34cd5acd44e7cb5c9513b6c45a13c2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06983-6https://doaj.org/toc/2045-2322Abstract We present a novel, non-invasive magnetic resonance imaging (MRI) technique to assess real-time dynamic vasomodulation of the microvascular bed. Unlike existing perfusion imaging techniques, our method is sensitive only to blood volume and not flow velocity. Using graded gas challenges and a long-life, blood-pool T 1-reducing agent gadofosveset, we can sensitively assess microvascular volume response in the liver, kidney cortex, and paraspinal muscle to vasoactive stimuli (i.e. hypercapnia, hypoxia, and hypercapnic hypoxia). Healthy adult rats were imaged on a 3 Tesla scanner and cycled through 10-minute gas intervals to elicit vasoconstriction followed by vasodilatation. Quantitative T 1 relaxation time mapping was performed dynamically; heart rate and blood oxygen saturation were continuously monitored. Laser Doppler perfusion measurements confirmed MRI findings: dynamic changes in T 1 corresponded with perfusion changes to graded gas challenges. Our new technique uncovered differential microvascular response to gas stimuli in different organs: for example, mild hypercapnia vasodilates the kidney cortex but constricts muscle vasculature. Finally, we present a gas challenge protocol that produces a consistent vasoactive response and can be used to assess vasomodulatory capacity. Our imaging approach to monitor real-time vasomodulation may be extended to other imaging modalities and is valuable for investigating diseases where microvascular health is compromised.Tameshwar GaneshMarvin EstradaHerman YegerJames DuffinHai-Ling Margaret ChengNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tameshwar Ganesh Marvin Estrada Herman Yeger James Duffin Hai-Ling Margaret Cheng A non-invasive magnetic resonance imaging approach for assessment of real-time microcirculation dynamics
description	Abstract We present a novel, non-invasive magnetic resonance imaging (MRI) technique to assess real-time dynamic vasomodulation of the microvascular bed. Unlike existing perfusion imaging techniques, our method is sensitive only to blood volume and not flow velocity. Using graded gas challenges and a long-life, blood-pool T 1-reducing agent gadofosveset, we can sensitively assess microvascular volume response in the liver, kidney cortex, and paraspinal muscle to vasoactive stimuli (i.e. hypercapnia, hypoxia, and hypercapnic hypoxia). Healthy adult rats were imaged on a 3 Tesla scanner and cycled through 10-minute gas intervals to elicit vasoconstriction followed by vasodilatation. Quantitative T 1 relaxation time mapping was performed dynamically; heart rate and blood oxygen saturation were continuously monitored. Laser Doppler perfusion measurements confirmed MRI findings: dynamic changes in T 1 corresponded with perfusion changes to graded gas challenges. Our new technique uncovered differential microvascular response to gas stimuli in different organs: for example, mild hypercapnia vasodilates the kidney cortex but constricts muscle vasculature. Finally, we present a gas challenge protocol that produces a consistent vasoactive response and can be used to assess vasomodulatory capacity. Our imaging approach to monitor real-time vasomodulation may be extended to other imaging modalities and is valuable for investigating diseases where microvascular health is compromised.
format	article
author	Tameshwar Ganesh Marvin Estrada Herman Yeger James Duffin Hai-Ling Margaret Cheng
author_facet	Tameshwar Ganesh Marvin Estrada Herman Yeger James Duffin Hai-Ling Margaret Cheng
author_sort	Tameshwar Ganesh
title	A non-invasive magnetic resonance imaging approach for assessment of real-time microcirculation dynamics
title_short	A non-invasive magnetic resonance imaging approach for assessment of real-time microcirculation dynamics
title_full	A non-invasive magnetic resonance imaging approach for assessment of real-time microcirculation dynamics
title_fullStr	A non-invasive magnetic resonance imaging approach for assessment of real-time microcirculation dynamics
title_full_unstemmed	A non-invasive magnetic resonance imaging approach for assessment of real-time microcirculation dynamics
title_sort	non-invasive magnetic resonance imaging approach for assessment of real-time microcirculation dynamics
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/11e34cd5acd44e7cb5c9513b6c45a13c
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A non-invasive magnetic resonance imaging approach for assessment of real-time microcirculation dynamics

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