Loss of PRC2 subunits primes lineage choice during exit of pluripotency

Polycomb Repressive Complex 2, an important regulator of embryonic development, exists in two configurations, PRC2.1 and PRC2.2. Here the authors dissect the functional contributions of these two PRC2 subunits and observed complex-specific alterations in the cell state of pluripotent and early diffe...

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Autores principales:	Chet H. Loh, Siebe van Genesen, Matteo Perino, Magnus R. Bark, Gert Jan C. Veenstra
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/11e461c83743498dbe76beae2bc660e6
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spelling	oai:doaj.org-article:11e461c83743498dbe76beae2bc660e62021-12-05T12:22:02ZLoss of PRC2 subunits primes lineage choice during exit of pluripotency10.1038/s41467-021-27314-42041-1723https://doaj.org/article/11e461c83743498dbe76beae2bc660e62021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27314-4https://doaj.org/toc/2041-1723Polycomb Repressive Complex 2, an important regulator of embryonic development, exists in two configurations, PRC2.1 and PRC2.2. Here the authors dissect the functional contributions of these two PRC2 subunits and observed complex-specific alterations in the cell state of pluripotent and early differentiating cells.Chet H. LohSiebe van GenesenMatteo PerinoMagnus R. BarkGert Jan C. VeenstraNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chet H. Loh Siebe van Genesen Matteo Perino Magnus R. Bark Gert Jan C. Veenstra Loss of PRC2 subunits primes lineage choice during exit of pluripotency
description	Polycomb Repressive Complex 2, an important regulator of embryonic development, exists in two configurations, PRC2.1 and PRC2.2. Here the authors dissect the functional contributions of these two PRC2 subunits and observed complex-specific alterations in the cell state of pluripotent and early differentiating cells.
format	article
author	Chet H. Loh Siebe van Genesen Matteo Perino Magnus R. Bark Gert Jan C. Veenstra
author_facet	Chet H. Loh Siebe van Genesen Matteo Perino Magnus R. Bark Gert Jan C. Veenstra
author_sort	Chet H. Loh
title	Loss of PRC2 subunits primes lineage choice during exit of pluripotency
title_short	Loss of PRC2 subunits primes lineage choice during exit of pluripotency
title_full	Loss of PRC2 subunits primes lineage choice during exit of pluripotency
title_fullStr	Loss of PRC2 subunits primes lineage choice during exit of pluripotency
title_full_unstemmed	Loss of PRC2 subunits primes lineage choice during exit of pluripotency
title_sort	loss of prc2 subunits primes lineage choice during exit of pluripotency
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/11e461c83743498dbe76beae2bc660e6
work_keys_str_mv	AT chethloh lossofprc2subunitsprimeslineagechoiceduringexitofpluripotency AT siebevangenesen lossofprc2subunitsprimeslineagechoiceduringexitofpluripotency AT matteoperino lossofprc2subunitsprimeslineagechoiceduringexitofpluripotency AT magnusrbark lossofprc2subunitsprimeslineagechoiceduringexitofpluripotency AT gertjancveenstra lossofprc2subunitsprimeslineagechoiceduringexitofpluripotency
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Loss of PRC2 subunits primes lineage choice during exit of pluripotency

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