Molecular evolution of PCSK family: Analysis of natural selection rate and gene loss.

Proprotein convertases subtilisin kexins are serine endoproteases, playing critical roles in the biological functions, including lipid, glucose, and bile acid metabolism, as well as cell proliferation, migration, and metastasis. Experimental studies have demonstrated the physiological functions of P...

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Autores principales:	Najmeh Parvaz, Zahra Jalali
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/11e4826b1bf94160bf868a2dbf0d5ebb
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spelling	oai:doaj.org-article:11e4826b1bf94160bf868a2dbf0d5ebb2021-12-02T20:16:27ZMolecular evolution of PCSK family: Analysis of natural selection rate and gene loss.1932-620310.1371/journal.pone.0259085https://doaj.org/article/11e4826b1bf94160bf868a2dbf0d5ebb2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0259085https://doaj.org/toc/1932-6203Proprotein convertases subtilisin kexins are serine endoproteases, playing critical roles in the biological functions, including lipid, glucose, and bile acid metabolism, as well as cell proliferation, migration, and metastasis. Experimental studies have demonstrated the physiological functions of PCSKs and their association with diseases; however, studies on the evolutionary history and diversification of these proteins are missing. In the present research, a bioinformatics study was conducted on the molecular evolution of several PCSKs family members and gene loss events across placental mammalian. In order to detect evolutionary constraints and positive selection, the CodeML program of the PAML package was used. The results showed the positive selection to occur in PCSK1, PCSK3, PCSK5, and PCSK7. A decelerated rate of evolution was observed in PCSK7, PCSK3, and MBTPS1 in Carnivores compared to the rest of phylogeny, and an accelerated evolution of PCSK1, PCSK7, and MBTPS1 in Muridae family of rodents was found. Additionally, our results indicated pcsk9 gene loss in 12 species comprising Carnivores and bats (Chiroptera). Future studies are required to evaluate the functional relevance and selective evolutionary advantages associated with these modifications in PCSK proteins during evolution.Najmeh ParvazZahra JalaliPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 10, p e0259085 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Najmeh Parvaz Zahra Jalali Molecular evolution of PCSK family: Analysis of natural selection rate and gene loss.
description	Proprotein convertases subtilisin kexins are serine endoproteases, playing critical roles in the biological functions, including lipid, glucose, and bile acid metabolism, as well as cell proliferation, migration, and metastasis. Experimental studies have demonstrated the physiological functions of PCSKs and their association with diseases; however, studies on the evolutionary history and diversification of these proteins are missing. In the present research, a bioinformatics study was conducted on the molecular evolution of several PCSKs family members and gene loss events across placental mammalian. In order to detect evolutionary constraints and positive selection, the CodeML program of the PAML package was used. The results showed the positive selection to occur in PCSK1, PCSK3, PCSK5, and PCSK7. A decelerated rate of evolution was observed in PCSK7, PCSK3, and MBTPS1 in Carnivores compared to the rest of phylogeny, and an accelerated evolution of PCSK1, PCSK7, and MBTPS1 in Muridae family of rodents was found. Additionally, our results indicated pcsk9 gene loss in 12 species comprising Carnivores and bats (Chiroptera). Future studies are required to evaluate the functional relevance and selective evolutionary advantages associated with these modifications in PCSK proteins during evolution.
format	article
author	Najmeh Parvaz Zahra Jalali
author_facet	Najmeh Parvaz Zahra Jalali
author_sort	Najmeh Parvaz
title	Molecular evolution of PCSK family: Analysis of natural selection rate and gene loss.
title_short	Molecular evolution of PCSK family: Analysis of natural selection rate and gene loss.
title_full	Molecular evolution of PCSK family: Analysis of natural selection rate and gene loss.
title_fullStr	Molecular evolution of PCSK family: Analysis of natural selection rate and gene loss.
title_full_unstemmed	Molecular evolution of PCSK family: Analysis of natural selection rate and gene loss.
title_sort	molecular evolution of pcsk family: analysis of natural selection rate and gene loss.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/11e4826b1bf94160bf868a2dbf0d5ebb
work_keys_str_mv	AT najmehparvaz molecularevolutionofpcskfamilyanalysisofnaturalselectionrateandgeneloss AT zahrajalali molecularevolutionofpcskfamilyanalysisofnaturalselectionrateandgeneloss
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Molecular evolution of PCSK family: Analysis of natural selection rate and gene loss.

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