Prediction of Graft Survival Post-liver Transplantation by L-GrAFT Risk Score Model, EASE Score, MEAF Scoring, and EAD
Background: Early allograft dysfunction (EAD) is correlated with poor patient or graft survival in liver transplantation. However, the power of distinct definitions of EAD in prediction of graft survival is unclear.Methods: This retrospective, single-center study reviewed data of 677 recipients unde...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:11e71aefdd03489cbc081394f9368e262021-11-19T04:54:40ZPrediction of Graft Survival Post-liver Transplantation by L-GrAFT Risk Score Model, EASE Score, MEAF Scoring, and EAD2296-875X10.3389/fsurg.2021.753056https://doaj.org/article/11e71aefdd03489cbc081394f9368e262021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fsurg.2021.753056/fullhttps://doaj.org/toc/2296-875XBackground: Early allograft dysfunction (EAD) is correlated with poor patient or graft survival in liver transplantation. However, the power of distinct definitions of EAD in prediction of graft survival is unclear.Methods: This retrospective, single-center study reviewed data of 677 recipients undergoing orthotopic liver transplant between July 2015 and June 2020. The following EAD definitions were compared: liver graft assessment following transplantation (L-GrAFT) risk score model, early allograft failure simplified estimation score (EASE), model for early allograft function (MEAF) scoring, and Olthoff criteria. Risk factors for L-GrAFT7 high risk group were evaluated with univariate and multivariable logistic regression analysis.Results: L-GrAFT7 had a satisfied C-statistic of 0.87 in predicting a 3-month graft survival which significantly outperformed MEAF (C-statistic = 0.78, P = 0.01) and EAD (C-statistic = 0.75, P < 0.001), respectively. L-GrAFT10, EASE was similar to L-GrAFT7, and they had no statistical significance in predicting survival. Laboratory model for end-stage liver disease score and cold ischemia time are risk factors of L-GrAFT7 high-risk group.Conclusion: L-GrAFT7 risk score is capable for better predicting the 3-month graft survival than the MEAF and EAD in a Chinese cohort, which might standardize assessment of early graft function and serve as a surrogate endpoint in clinical trial.Shirui ChenShirui ChenShirui ChenTielong WangTielong WangTielong WangTao LuoTao LuoTao LuoShujiao HeShujiao HeShujiao HeChangjun HuangChangjun HuangChangjun HuangZehua JiaZehua JiaZehua JiaLiqiang ZhanLiqiang ZhanLiqiang ZhanDongping WangDongping WangDongping WangXiaofeng ZhuXiaofeng ZhuXiaofeng ZhuZhiyong GuoZhiyong GuoZhiyong GuoXiaoshun HeXiaoshun HeXiaoshun HeFrontiers Media S.A.articleorthotopic liver transplantationrisk prediction modelmachine perfusionrisk factorgraft survivalpatient survivabilitySurgeryRD1-811ENFrontiers in Surgery, Vol 8 (2021) |
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DOAJ |
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EN |
| topic |
orthotopic liver transplantation risk prediction model machine perfusion risk factor graft survival patient survivability Surgery RD1-811 |
| spellingShingle |
orthotopic liver transplantation risk prediction model machine perfusion risk factor graft survival patient survivability Surgery RD1-811 Shirui Chen Shirui Chen Shirui Chen Tielong Wang Tielong Wang Tielong Wang Tao Luo Tao Luo Tao Luo Shujiao He Shujiao He Shujiao He Changjun Huang Changjun Huang Changjun Huang Zehua Jia Zehua Jia Zehua Jia Liqiang Zhan Liqiang Zhan Liqiang Zhan Dongping Wang Dongping Wang Dongping Wang Xiaofeng Zhu Xiaofeng Zhu Xiaofeng Zhu Zhiyong Guo Zhiyong Guo Zhiyong Guo Xiaoshun He Xiaoshun He Xiaoshun He Prediction of Graft Survival Post-liver Transplantation by L-GrAFT Risk Score Model, EASE Score, MEAF Scoring, and EAD |
| description |
Background: Early allograft dysfunction (EAD) is correlated with poor patient or graft survival in liver transplantation. However, the power of distinct definitions of EAD in prediction of graft survival is unclear.Methods: This retrospective, single-center study reviewed data of 677 recipients undergoing orthotopic liver transplant between July 2015 and June 2020. The following EAD definitions were compared: liver graft assessment following transplantation (L-GrAFT) risk score model, early allograft failure simplified estimation score (EASE), model for early allograft function (MEAF) scoring, and Olthoff criteria. Risk factors for L-GrAFT7 high risk group were evaluated with univariate and multivariable logistic regression analysis.Results: L-GrAFT7 had a satisfied C-statistic of 0.87 in predicting a 3-month graft survival which significantly outperformed MEAF (C-statistic = 0.78, P = 0.01) and EAD (C-statistic = 0.75, P < 0.001), respectively. L-GrAFT10, EASE was similar to L-GrAFT7, and they had no statistical significance in predicting survival. Laboratory model for end-stage liver disease score and cold ischemia time are risk factors of L-GrAFT7 high-risk group.Conclusion: L-GrAFT7 risk score is capable for better predicting the 3-month graft survival than the MEAF and EAD in a Chinese cohort, which might standardize assessment of early graft function and serve as a surrogate endpoint in clinical trial. |
| format |
article |
| author |
Shirui Chen Shirui Chen Shirui Chen Tielong Wang Tielong Wang Tielong Wang Tao Luo Tao Luo Tao Luo Shujiao He Shujiao He Shujiao He Changjun Huang Changjun Huang Changjun Huang Zehua Jia Zehua Jia Zehua Jia Liqiang Zhan Liqiang Zhan Liqiang Zhan Dongping Wang Dongping Wang Dongping Wang Xiaofeng Zhu Xiaofeng Zhu Xiaofeng Zhu Zhiyong Guo Zhiyong Guo Zhiyong Guo Xiaoshun He Xiaoshun He Xiaoshun He |
| author_facet |
Shirui Chen Shirui Chen Shirui Chen Tielong Wang Tielong Wang Tielong Wang Tao Luo Tao Luo Tao Luo Shujiao He Shujiao He Shujiao He Changjun Huang Changjun Huang Changjun Huang Zehua Jia Zehua Jia Zehua Jia Liqiang Zhan Liqiang Zhan Liqiang Zhan Dongping Wang Dongping Wang Dongping Wang Xiaofeng Zhu Xiaofeng Zhu Xiaofeng Zhu Zhiyong Guo Zhiyong Guo Zhiyong Guo Xiaoshun He Xiaoshun He Xiaoshun He |
| author_sort |
Shirui Chen |
| title |
Prediction of Graft Survival Post-liver Transplantation by L-GrAFT Risk Score Model, EASE Score, MEAF Scoring, and EAD |
| title_short |
Prediction of Graft Survival Post-liver Transplantation by L-GrAFT Risk Score Model, EASE Score, MEAF Scoring, and EAD |
| title_full |
Prediction of Graft Survival Post-liver Transplantation by L-GrAFT Risk Score Model, EASE Score, MEAF Scoring, and EAD |
| title_fullStr |
Prediction of Graft Survival Post-liver Transplantation by L-GrAFT Risk Score Model, EASE Score, MEAF Scoring, and EAD |
| title_full_unstemmed |
Prediction of Graft Survival Post-liver Transplantation by L-GrAFT Risk Score Model, EASE Score, MEAF Scoring, and EAD |
| title_sort |
prediction of graft survival post-liver transplantation by l-graft risk score model, ease score, meaf scoring, and ead |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/11e71aefdd03489cbc081394f9368e26 |
| work_keys_str_mv |
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