EFFICACY OF INTRAPERITONEAL INTERFERON-α ADMINISTRATION FOR TREATMENT OF ENDOMETRIOSIS IN RATS

Abstract. The article presents the results of intraperitoneal administration of recombinant rat interferon-α to twenty Wistar rats with experimentally induced endometriosis. The following criteria of treatment efficiency were applied: presence of ectopic endometrium in transplanted segments of cornu...

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Autores principales:	R. V. Pavlov, S. A. Selkov
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	endometriosis treatment interferon Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/11e871a95b274a5aaed772d4ea1fedcc
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spelling	oai:doaj.org-article:11e871a95b274a5aaed772d4ea1fedcc2021-11-18T08:03:42ZEFFICACY OF INTRAPERITONEAL INTERFERON-α ADMINISTRATION FOR TREATMENT OF ENDOMETRIOSIS IN RATS1563-06252313-741X10.15789/1563-0625-2006-5-6-721-726https://doaj.org/article/11e871a95b274a5aaed772d4ea1fedcc2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/582https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. The article presents the results of intraperitoneal administration of recombinant rat interferon-α to twenty Wistar rats with experimentally induced endometriosis. The following criteria of treatment efficiency were applied: presence of ectopic endometrium in transplanted segments of cornu uteri, proliferative activity of endometrioid cells, features of vascularization and leucocyte infiltration within endometrial foci. It was shown that local application of interferon-α caused regression of endometrioid epithelial heterotopias in 50 per cent of the cases. If endometrioid epithelium was retained, its proliferative activity did significantly drop under interferon-α application. In all transplants derived from rats treated with interferon-α, the degree of vascularization is reduced, accompanied by increased leucocytic infiltration (due to lymphocytes), along with decreased contents of macrophages within leucocytic infiltrates.R. V. PavlovS. A. SelkovSPb RAACIarticleendometriosistreatmentinterferonImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 8, Iss 5-6, Pp 721-726 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	endometriosis treatment interferon Immunologic diseases. Allergy RC581-607
spellingShingle	endometriosis treatment interferon Immunologic diseases. Allergy RC581-607 R. V. Pavlov S. A. Selkov EFFICACY OF INTRAPERITONEAL INTERFERON-α ADMINISTRATION FOR TREATMENT OF ENDOMETRIOSIS IN RATS
description	Abstract. The article presents the results of intraperitoneal administration of recombinant rat interferon-α to twenty Wistar rats with experimentally induced endometriosis. The following criteria of treatment efficiency were applied: presence of ectopic endometrium in transplanted segments of cornu uteri, proliferative activity of endometrioid cells, features of vascularization and leucocyte infiltration within endometrial foci. It was shown that local application of interferon-α caused regression of endometrioid epithelial heterotopias in 50 per cent of the cases. If endometrioid epithelium was retained, its proliferative activity did significantly drop under interferon-α application. In all transplants derived from rats treated with interferon-α, the degree of vascularization is reduced, accompanied by increased leucocytic infiltration (due to lymphocytes), along with decreased contents of macrophages within leucocytic infiltrates.
format	article
author	R. V. Pavlov S. A. Selkov
author_facet	R. V. Pavlov S. A. Selkov
author_sort	R. V. Pavlov
title	EFFICACY OF INTRAPERITONEAL INTERFERON-α ADMINISTRATION FOR TREATMENT OF ENDOMETRIOSIS IN RATS
title_short	EFFICACY OF INTRAPERITONEAL INTERFERON-α ADMINISTRATION FOR TREATMENT OF ENDOMETRIOSIS IN RATS
title_full	EFFICACY OF INTRAPERITONEAL INTERFERON-α ADMINISTRATION FOR TREATMENT OF ENDOMETRIOSIS IN RATS
title_fullStr	EFFICACY OF INTRAPERITONEAL INTERFERON-α ADMINISTRATION FOR TREATMENT OF ENDOMETRIOSIS IN RATS
title_full_unstemmed	EFFICACY OF INTRAPERITONEAL INTERFERON-α ADMINISTRATION FOR TREATMENT OF ENDOMETRIOSIS IN RATS
title_sort	efficacy of intraperitoneal interferon-α administration for treatment of endometriosis in rats
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/11e871a95b274a5aaed772d4ea1fedcc
work_keys_str_mv	AT rvpavlov efficacyofintraperitonealinterferonaadministrationfortreatmentofendometriosisinrats AT saselkov efficacyofintraperitonealinterferonaadministrationfortreatmentofendometriosisinrats
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EFFICACY OF INTRAPERITONEAL INTERFERON-α ADMINISTRATION FOR TREATMENT OF ENDOMETRIOSIS IN RATS

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