Telocytes contribute to aging-related modifications in the prostate

Abstract Telocytes are interstitial cells present in the stroma of several organs, including the prostate. There is evidence that these cells are present during prostate alveologenesis, in which these cells play a relevant role, but there is no information about the presence of and possible changes...

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Autores principales:	Bruno Domingos Azevedo Sanches, Guilherme Henrique Tamarindo, Juliana dos Santos Maldarine, Alana Della Torre da Silva, Vitória Alário dos Santos, Maria Letícia Duarte Lima, Paula Rahal, Rejane Maira Góes, Sebastião Roberto Taboga, Sérgio Luis Felisbino, Hernandes F. Carvalho
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/11eb0b0f0ca04ac2ab57aa5c7018f9c1
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spelling	oai:doaj.org-article:11eb0b0f0ca04ac2ab57aa5c7018f9c12021-12-02T15:10:18ZTelocytes contribute to aging-related modifications in the prostate10.1038/s41598-020-78532-72045-2322https://doaj.org/article/11eb0b0f0ca04ac2ab57aa5c7018f9c12020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78532-7https://doaj.org/toc/2045-2322Abstract Telocytes are interstitial cells present in the stroma of several organs, including the prostate. There is evidence that these cells are present during prostate alveologenesis, in which these cells play a relevant role, but there is no information about the presence of and possible changes in telocytes during prostate aging. Throughout aging, the prostate undergoes several spontaneous changes in the stroma that are pro-pathogenic. Our study used histochemistry, 3D reconstructions, ultrastructure and immunofluorescence to compare the adult prostate with the senile prostate of the Mongolian gerbil, in order to investigate possible changes in telocytes with senescence and a possible role for these cells in the age-associated alterations. It was found that the layers of perialveolar smooth muscle become thinner as the prostatic alveoli become more dilated during aging, and that telocytes form a network that involves smooth muscle cells, which could possibly indicate a role for telocytes in maintaining the integrity of perialveolar smooth muscles. On the other hand, with senescence, VEGF+ telocytes are seen in stroma possibly contributing to angiogenesis, together with TNFR1+ telocytes, which are associated with a pro-inflammatory microenvironment in the prostate. Together, these data indicate that telocytes are important both in understanding the aging-related changes that are seen in the prostate and also in the search for new therapeutic targets for pathologies whose frequency increases with age.Bruno Domingos Azevedo SanchesGuilherme Henrique TamarindoJuliana dos Santos MaldarineAlana Della Torre da SilvaVitória Alário dos SantosMaria Letícia Duarte LimaPaula RahalRejane Maira GóesSebastião Roberto TabogaSérgio Luis FelisbinoHernandes F. CarvalhoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Bruno Domingos Azevedo Sanches Guilherme Henrique Tamarindo Juliana dos Santos Maldarine Alana Della Torre da Silva Vitória Alário dos Santos Maria Letícia Duarte Lima Paula Rahal Rejane Maira Góes Sebastião Roberto Taboga Sérgio Luis Felisbino Hernandes F. Carvalho Telocytes contribute to aging-related modifications in the prostate
description	Abstract Telocytes are interstitial cells present in the stroma of several organs, including the prostate. There is evidence that these cells are present during prostate alveologenesis, in which these cells play a relevant role, but there is no information about the presence of and possible changes in telocytes during prostate aging. Throughout aging, the prostate undergoes several spontaneous changes in the stroma that are pro-pathogenic. Our study used histochemistry, 3D reconstructions, ultrastructure and immunofluorescence to compare the adult prostate with the senile prostate of the Mongolian gerbil, in order to investigate possible changes in telocytes with senescence and a possible role for these cells in the age-associated alterations. It was found that the layers of perialveolar smooth muscle become thinner as the prostatic alveoli become more dilated during aging, and that telocytes form a network that involves smooth muscle cells, which could possibly indicate a role for telocytes in maintaining the integrity of perialveolar smooth muscles. On the other hand, with senescence, VEGF+ telocytes are seen in stroma possibly contributing to angiogenesis, together with TNFR1+ telocytes, which are associated with a pro-inflammatory microenvironment in the prostate. Together, these data indicate that telocytes are important both in understanding the aging-related changes that are seen in the prostate and also in the search for new therapeutic targets for pathologies whose frequency increases with age.
format	article
author	Bruno Domingos Azevedo Sanches Guilherme Henrique Tamarindo Juliana dos Santos Maldarine Alana Della Torre da Silva Vitória Alário dos Santos Maria Letícia Duarte Lima Paula Rahal Rejane Maira Góes Sebastião Roberto Taboga Sérgio Luis Felisbino Hernandes F. Carvalho
author_facet	Bruno Domingos Azevedo Sanches Guilherme Henrique Tamarindo Juliana dos Santos Maldarine Alana Della Torre da Silva Vitória Alário dos Santos Maria Letícia Duarte Lima Paula Rahal Rejane Maira Góes Sebastião Roberto Taboga Sérgio Luis Felisbino Hernandes F. Carvalho
author_sort	Bruno Domingos Azevedo Sanches
title	Telocytes contribute to aging-related modifications in the prostate
title_short	Telocytes contribute to aging-related modifications in the prostate
title_full	Telocytes contribute to aging-related modifications in the prostate
title_fullStr	Telocytes contribute to aging-related modifications in the prostate
title_full_unstemmed	Telocytes contribute to aging-related modifications in the prostate
title_sort	telocytes contribute to aging-related modifications in the prostate
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/11eb0b0f0ca04ac2ab57aa5c7018f9c1
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Telocytes contribute to aging-related modifications in the prostate

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