Evaluation of Efficacy and Safety Topical 5-Fluorouracil 0.5% in Treatment of Resistant Vitiligo [Alone or After Microneedling]; A pilot Study

Background: Vitiligo is a chronic acquired disorder characterized by the depigmented macules. There are many treatment options, but the response is variable and unsatisfactory. Topical 5-fluorouracil used in many dermatological diseases but, this is the first study to date that use 0.5% concentratio...

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Autores principales:	Sara Galal, Moshiraly Ali, Fatma Elzeiny
Formato:	article
Lenguaje:	EN
Publicado:	Al-Azhar University, Faculty of Medicine (Damietta) 2021
Materias:	5-fluorouracil 0.5% microneedling pigmentation vitiligo Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/11f0ba5ad10643589c16b9384fb5f977
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spelling	oai:doaj.org-article:11f0ba5ad10643589c16b9384fb5f9772021-12-02T19:33:14ZEvaluation of Efficacy and Safety Topical 5-Fluorouracil 0.5% in Treatment of Resistant Vitiligo [Alone or After Microneedling]; A pilot Study2636-41742682-378010.21608/ijma.2021.89242.1347https://doaj.org/article/11f0ba5ad10643589c16b9384fb5f9772021-10-01T00:00:00Zhttps://ijma.journals.ekb.eg/article_193556_6106a3e936814afda52fe162013069db.pdfhttps://doaj.org/toc/2636-4174https://doaj.org/toc/2682-3780Background: Vitiligo is a chronic acquired disorder characterized by the depigmented macules. There are many treatment options, but the response is variable and unsatisfactory. Topical 5-fluorouracil used in many dermatological diseases but, this is the first study to date that use 0.5% concentration in vitiligo treatment.The Aim of The Work: This study evaluates efficacy and safety topical 5-fluorouracil in 0.5% concentration in treatment of resistant vitiligo either alone or after microneedling.Subject and Methods: 30 patients with resistant vitiligo were enrolled into the study; we studied only 2 patches in every patient. The first patch treated with one session of microneedling followed by topical 5-fluorouracil 0.5% once daily for 2 weeks. The second patch treated with topical 5-fluorouracil 0.5% only for 2 weeks, then follow up of both patches for 3 months.Results: Excellent response achieved in 46.7% of the patches treated with microneedling followed by topical 5-fluorouracil 0.5%, while only in 23.3% of the patches treated with topical 5-fluorouracil 0.5% alone. There was no significant difference between both groups regarding response, despite this the degree of improvement was higher in combined treatment.Conclusion: Topical 5-fluorouracil 0.5% is an effective and safe in treatment of resistant vitiligo and combined therapy increases the efficacy.Sara GalalMoshiraly AliFatma ElzeinyAl-Azhar University, Faculty of Medicine (Damietta)article5-fluorouracil 0.5%microneedlingpigmentationvitiligoMedicine (General)R5-920ENInternational Journal of Medical Arts, Vol 3, Iss 4, Pp 1803-1810 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	5-fluorouracil 0.5% microneedling pigmentation vitiligo Medicine (General) R5-920
spellingShingle	5-fluorouracil 0.5% microneedling pigmentation vitiligo Medicine (General) R5-920 Sara Galal Moshiraly Ali Fatma Elzeiny Evaluation of Efficacy and Safety Topical 5-Fluorouracil 0.5% in Treatment of Resistant Vitiligo [Alone or After Microneedling]; A pilot Study
description	Background: Vitiligo is a chronic acquired disorder characterized by the depigmented macules. There are many treatment options, but the response is variable and unsatisfactory. Topical 5-fluorouracil used in many dermatological diseases but, this is the first study to date that use 0.5% concentration in vitiligo treatment.The Aim of The Work: This study evaluates efficacy and safety topical 5-fluorouracil in 0.5% concentration in treatment of resistant vitiligo either alone or after microneedling.Subject and Methods: 30 patients with resistant vitiligo were enrolled into the study; we studied only 2 patches in every patient. The first patch treated with one session of microneedling followed by topical 5-fluorouracil 0.5% once daily for 2 weeks. The second patch treated with topical 5-fluorouracil 0.5% only for 2 weeks, then follow up of both patches for 3 months.Results: Excellent response achieved in 46.7% of the patches treated with microneedling followed by topical 5-fluorouracil 0.5%, while only in 23.3% of the patches treated with topical 5-fluorouracil 0.5% alone. There was no significant difference between both groups regarding response, despite this the degree of improvement was higher in combined treatment.Conclusion: Topical 5-fluorouracil 0.5% is an effective and safe in treatment of resistant vitiligo and combined therapy increases the efficacy.
format	article
author	Sara Galal Moshiraly Ali Fatma Elzeiny
author_facet	Sara Galal Moshiraly Ali Fatma Elzeiny
author_sort	Sara Galal
title	Evaluation of Efficacy and Safety Topical 5-Fluorouracil 0.5% in Treatment of Resistant Vitiligo [Alone or After Microneedling]; A pilot Study
title_short	Evaluation of Efficacy and Safety Topical 5-Fluorouracil 0.5% in Treatment of Resistant Vitiligo [Alone or After Microneedling]; A pilot Study
title_full	Evaluation of Efficacy and Safety Topical 5-Fluorouracil 0.5% in Treatment of Resistant Vitiligo [Alone or After Microneedling]; A pilot Study
title_fullStr	Evaluation of Efficacy and Safety Topical 5-Fluorouracil 0.5% in Treatment of Resistant Vitiligo [Alone or After Microneedling]; A pilot Study
title_full_unstemmed	Evaluation of Efficacy and Safety Topical 5-Fluorouracil 0.5% in Treatment of Resistant Vitiligo [Alone or After Microneedling]; A pilot Study
title_sort	evaluation of efficacy and safety topical 5-fluorouracil 0.5% in treatment of resistant vitiligo [alone or after microneedling]; a pilot study
publisher	Al-Azhar University, Faculty of Medicine (Damietta)
publishDate	2021
url	https://doaj.org/article/11f0ba5ad10643589c16b9384fb5f977
work_keys_str_mv	AT saragalal evaluationofefficacyandsafetytopical5fluorouracil05intreatmentofresistantvitiligoaloneoraftermicroneedlingapilotstudy AT moshiralyali evaluationofefficacyandsafetytopical5fluorouracil05intreatmentofresistantvitiligoaloneoraftermicroneedlingapilotstudy AT fatmaelzeiny evaluationofefficacyandsafetytopical5fluorouracil05intreatmentofresistantvitiligoaloneoraftermicroneedlingapilotstudy
_version_	1718376364550127616

Evaluation of Efficacy and Safety Topical 5-Fluorouracil 0.5% in Treatment of Resistant Vitiligo [Alone or After Microneedling]; A pilot Study

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