Mitochondrial DAMPs induce endotoxin tolerance in human monocytes: an observation in patients with myocardial infarction.
Monocyte exposure to mitochondrial Danger Associated Molecular Patterns (DAMPs), including mitochondrial DNA (mtDNA), induces a transient state in which these cells are refractory to further endotoxin stimulation. In this context, IRAK-M up-regulation and impaired p65 activity were observed. This ph...
Saved in:
Main Authors: | Irene Fernández-Ruiz, Francisco Arnalich, Carolina Cubillos-Zapata, Enrique Hernández-Jiménez, Raúl Moreno-González, Víctor Toledano, María Fernández-Velasco, Maria T Vallejo-Cremades, Laura Esteban-Burgos, Rebeca Pérez de Diego, Miguel A Llamas-Matias, Elena García-Arumi, Ramón Martí, Lisardo Boscá, Antoni L Andreu, José Luis López-Sendón, Eduardo López-Collazo |
---|---|
Format: | article |
Language: | EN |
Published: |
Public Library of Science (PLoS)
2014
|
Subjects: | |
Online Access: | https://doaj.org/article/11f38959cab14f00b2cb0de2cbeccdc9 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Translocated LPS might cause endotoxin tolerance in circulating monocytes of cystic fibrosis patients.
by: Rosa del Campo, et al.
Published: (2011) -
Monocytes from depressed patients display an altered pattern of response to endotoxin challenge.
by: Lucia Lisi, et al.
Published: (2013) -
Quantity of alcohol drinking positively correlates with serum levels of endotoxin and markers of monocyte activation
by: Suthat Liangpunsakul, et al.
Published: (2017) -
Global analysis of glycoproteins identifies markers of endotoxin tolerant monocytes and GPR84 as a modulator of TNFα expression
by: Mario M. Müller, et al.
Published: (2017) -
JAK2-STAT Epigenetically Regulates Tolerized Genes in Monocytes in the First Encounter With Gram-Negative Bacterial Endotoxins in Sepsis
by: Octavio Morante-Palacios, et al.
Published: (2021)