Structure of the 4-1BB/4-1BBL complex and distinct binding and functional properties of utomilumab and urelumab

The costimulatory T-cell receptor 4-1BB is an immuno-oncology target. Here the authors present the ligand bound 4-1BB receptor crystal structure in addition to the structures of 4-1BB bound with two therapeutic antibodies and verify the antibody binding sites by mutational analysis, which is of inte...

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Autores principales:	S. Michael Chin, Christopher R. Kimberlin, Zygy Roe-Zurz, Pamela Zhang, Allison Xu, Sindy Liao-Chan, Debasish Sen, Andrew R. Nager, Nicole Schirle Oakdale, Colleen Brown, Feng Wang, Yuting Yang, Kevin Lindquist, Yik Andy Yeung, Shahram Salek-Ardakani, Javier Chaparro-Riggers
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/11f466e447544959a4ac278b485a238c
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spelling	oai:doaj.org-article:11f466e447544959a4ac278b485a238c2021-12-02T17:31:57ZStructure of the 4-1BB/4-1BBL complex and distinct binding and functional properties of utomilumab and urelumab10.1038/s41467-018-07136-72041-1723https://doaj.org/article/11f466e447544959a4ac278b485a238c2018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07136-7https://doaj.org/toc/2041-1723The costimulatory T-cell receptor 4-1BB is an immuno-oncology target. Here the authors present the ligand bound 4-1BB receptor crystal structure in addition to the structures of 4-1BB bound with two therapeutic antibodies and verify the antibody binding sites by mutational analysis, which is of interest for further 4-1BB therapeutics development.S. Michael ChinChristopher R. KimberlinZygy Roe-ZurzPamela ZhangAllison XuSindy Liao-ChanDebasish SenAndrew R. NagerNicole Schirle OakdaleColleen BrownFeng WangYuting YangKevin LindquistYik Andy YeungShahram Salek-ArdakaniJavier Chaparro-RiggersNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q S. Michael Chin Christopher R. Kimberlin Zygy Roe-Zurz Pamela Zhang Allison Xu Sindy Liao-Chan Debasish Sen Andrew R. Nager Nicole Schirle Oakdale Colleen Brown Feng Wang Yuting Yang Kevin Lindquist Yik Andy Yeung Shahram Salek-Ardakani Javier Chaparro-Riggers Structure of the 4-1BB/4-1BBL complex and distinct binding and functional properties of utomilumab and urelumab
description	The costimulatory T-cell receptor 4-1BB is an immuno-oncology target. Here the authors present the ligand bound 4-1BB receptor crystal structure in addition to the structures of 4-1BB bound with two therapeutic antibodies and verify the antibody binding sites by mutational analysis, which is of interest for further 4-1BB therapeutics development.
format	article
author	S. Michael Chin Christopher R. Kimberlin Zygy Roe-Zurz Pamela Zhang Allison Xu Sindy Liao-Chan Debasish Sen Andrew R. Nager Nicole Schirle Oakdale Colleen Brown Feng Wang Yuting Yang Kevin Lindquist Yik Andy Yeung Shahram Salek-Ardakani Javier Chaparro-Riggers
author_facet	S. Michael Chin Christopher R. Kimberlin Zygy Roe-Zurz Pamela Zhang Allison Xu Sindy Liao-Chan Debasish Sen Andrew R. Nager Nicole Schirle Oakdale Colleen Brown Feng Wang Yuting Yang Kevin Lindquist Yik Andy Yeung Shahram Salek-Ardakani Javier Chaparro-Riggers
author_sort	S. Michael Chin
title	Structure of the 4-1BB/4-1BBL complex and distinct binding and functional properties of utomilumab and urelumab
title_short	Structure of the 4-1BB/4-1BBL complex and distinct binding and functional properties of utomilumab and urelumab
title_full	Structure of the 4-1BB/4-1BBL complex and distinct binding and functional properties of utomilumab and urelumab
title_fullStr	Structure of the 4-1BB/4-1BBL complex and distinct binding and functional properties of utomilumab and urelumab
title_full_unstemmed	Structure of the 4-1BB/4-1BBL complex and distinct binding and functional properties of utomilumab and urelumab
title_sort	structure of the 4-1bb/4-1bbl complex and distinct binding and functional properties of utomilumab and urelumab
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/11f466e447544959a4ac278b485a238c
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Structure of the 4-1BB/4-1BBL complex and distinct binding and functional properties of utomilumab and urelumab

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