Structure of the 4-1BB/4-1BBL complex and distinct binding and functional properties of utomilumab and urelumab

Structure of the 4-1BB/4-1BBL complex and distinct binding and functional properties of utomilumab and urelumab

The costimulatory T-cell receptor 4-1BB is an immuno-oncology target. Here the authors present the ligand bound 4-1BB receptor crystal structure in addition to the structures of 4-1BB bound with two therapeutic antibodies and verify the antibody binding sites by mutational analysis, which is of inte...

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Autores principales: S. Michael Chin, Christopher R. Kimberlin, Zygy Roe-Zurz, Pamela Zhang, Allison Xu, Sindy Liao-Chan, Debasish Sen, Andrew R. Nager, Nicole Schirle Oakdale, Colleen Brown, Feng Wang, Yuting Yang, Kevin Lindquist, Yik Andy Yeung, Shahram Salek-Ardakani, Javier Chaparro-Riggers
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Science
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Acceso en línea:https://doaj.org/article/11f466e447544959a4ac278b485a238c
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