Sequence variation at ANAPC1 accounts for 24% of the variability in corneal endothelial cell density
The corneal endothelium is crucial for proper vision. Here, Ivarsdottir et al. perform genome-wide association studies for various corneal endothelial cell measurements and find that an intergenic variant near ANAPC1 explains 24% of the variance of endothelial cell density and associates with cornea...
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Nature Portfolio
2019
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oai:doaj.org-article:11f4c12f2e434eab98745914146fa7152021-12-02T17:01:58ZSequence variation at ANAPC1 accounts for 24% of the variability in corneal endothelial cell density10.1038/s41467-019-09304-92041-1723https://doaj.org/article/11f4c12f2e434eab98745914146fa7152019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09304-9https://doaj.org/toc/2041-1723The corneal endothelium is crucial for proper vision. Here, Ivarsdottir et al. perform genome-wide association studies for various corneal endothelial cell measurements and find that an intergenic variant near ANAPC1 explains 24% of the variance of endothelial cell density and associates with corneal hysteresis.Erna V. IvarsdottirStefania BenonisdottirGudmar ThorleifssonPatrick SulemAsmundur OddssonUnnur StyrkarsdottirSnaedis KristmundsdottirGudny A. ArnadottirGudmundur ThorgeirssonIngileif JonsdottirGunnar M. ZoegaUnnur ThorsteinsdottirDaniel F. GudbjartssonFridbert JonassonHilma HolmKari StefanssonNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019) |
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Science Q Erna V. Ivarsdottir Stefania Benonisdottir Gudmar Thorleifsson Patrick Sulem Asmundur Oddsson Unnur Styrkarsdottir Snaedis Kristmundsdottir Gudny A. Arnadottir Gudmundur Thorgeirsson Ingileif Jonsdottir Gunnar M. Zoega Unnur Thorsteinsdottir Daniel F. Gudbjartsson Fridbert Jonasson Hilma Holm Kari Stefansson Sequence variation at ANAPC1 accounts for 24% of the variability in corneal endothelial cell density |
| description |
The corneal endothelium is crucial for proper vision. Here, Ivarsdottir et al. perform genome-wide association studies for various corneal endothelial cell measurements and find that an intergenic variant near ANAPC1 explains 24% of the variance of endothelial cell density and associates with corneal hysteresis. |
| format |
article |
| author |
Erna V. Ivarsdottir Stefania Benonisdottir Gudmar Thorleifsson Patrick Sulem Asmundur Oddsson Unnur Styrkarsdottir Snaedis Kristmundsdottir Gudny A. Arnadottir Gudmundur Thorgeirsson Ingileif Jonsdottir Gunnar M. Zoega Unnur Thorsteinsdottir Daniel F. Gudbjartsson Fridbert Jonasson Hilma Holm Kari Stefansson |
| author_facet |
Erna V. Ivarsdottir Stefania Benonisdottir Gudmar Thorleifsson Patrick Sulem Asmundur Oddsson Unnur Styrkarsdottir Snaedis Kristmundsdottir Gudny A. Arnadottir Gudmundur Thorgeirsson Ingileif Jonsdottir Gunnar M. Zoega Unnur Thorsteinsdottir Daniel F. Gudbjartsson Fridbert Jonasson Hilma Holm Kari Stefansson |
| author_sort |
Erna V. Ivarsdottir |
| title |
Sequence variation at ANAPC1 accounts for 24% of the variability in corneal endothelial cell density |
| title_short |
Sequence variation at ANAPC1 accounts for 24% of the variability in corneal endothelial cell density |
| title_full |
Sequence variation at ANAPC1 accounts for 24% of the variability in corneal endothelial cell density |
| title_fullStr |
Sequence variation at ANAPC1 accounts for 24% of the variability in corneal endothelial cell density |
| title_full_unstemmed |
Sequence variation at ANAPC1 accounts for 24% of the variability in corneal endothelial cell density |
| title_sort |
sequence variation at anapc1 accounts for 24% of the variability in corneal endothelial cell density |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/11f4c12f2e434eab98745914146fa715 |
| work_keys_str_mv |
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| _version_ |
1718381951549702144 |