Dynamics and variability in the pleiotropic effects of adaptation in laboratory budding yeast populations

Evolutionary adaptation to a constant environment is driven by the accumulation of mutations which can have a range of unrealized pleiotropic effects in other environments. These pleiotropic consequences of adaptation can influence the emergence of specialists or generalists, and are critical for ev...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Christopher W Bakerlee, Angela M Phillips, Alex N Nguyen Ba, Michael M Desai
Formato: article
Lenguaje:EN
Publicado: eLife Sciences Publications Ltd 2021
Materias:
R
Q
Acceso en línea:https://doaj.org/article/11f5bf11feae423aa676a36ecff8e924
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:11f5bf11feae423aa676a36ecff8e924
record_format dspace
spelling oai:doaj.org-article:11f5bf11feae423aa676a36ecff8e9242021-11-09T15:53:51ZDynamics and variability in the pleiotropic effects of adaptation in laboratory budding yeast populations10.7554/eLife.709182050-084Xe70918https://doaj.org/article/11f5bf11feae423aa676a36ecff8e9242021-10-01T00:00:00Zhttps://elifesciences.org/articles/70918https://doaj.org/toc/2050-084XEvolutionary adaptation to a constant environment is driven by the accumulation of mutations which can have a range of unrealized pleiotropic effects in other environments. These pleiotropic consequences of adaptation can influence the emergence of specialists or generalists, and are critical for evolution in temporally or spatially fluctuating environments. While many experiments have examined the pleiotropic effects of adaptation at a snapshot in time, very few have observed the dynamics by which these effects emerge and evolve. Here, we propagated hundreds of diploid and haploid laboratory budding yeast populations in each of three environments, and then assayed their fitness in multiple environments over 1000 generations of evolution. We find that replicate populations evolved in the same condition share common patterns of pleiotropic effects across other environments, which emerge within the first several hundred generations of evolution. However, we also find dynamic and environment-specific variability within these trends: variability in pleiotropic effects tends to increase over time, with the extent of variability depending on the evolution environment. These results suggest shifting and overlapping contributions of chance and contingency to the pleiotropic effects of adaptation, which could influence evolutionary trajectories in complex environments that fluctuate across space and time.Christopher W BakerleeAngela M PhillipsAlex N Nguyen BaMichael M DesaieLife Sciences Publications Ltdarticleevolutionary dynamicspleiotropyadaptationMedicineRScienceQBiology (General)QH301-705.5ENeLife, Vol 10 (2021)
institution DOAJ
collection DOAJ
language EN
topic evolutionary dynamics
pleiotropy
adaptation
Medicine
R
Science
Q
Biology (General)
QH301-705.5
spellingShingle evolutionary dynamics
pleiotropy
adaptation
Medicine
R
Science
Q
Biology (General)
QH301-705.5
Christopher W Bakerlee
Angela M Phillips
Alex N Nguyen Ba
Michael M Desai
Dynamics and variability in the pleiotropic effects of adaptation in laboratory budding yeast populations
description Evolutionary adaptation to a constant environment is driven by the accumulation of mutations which can have a range of unrealized pleiotropic effects in other environments. These pleiotropic consequences of adaptation can influence the emergence of specialists or generalists, and are critical for evolution in temporally or spatially fluctuating environments. While many experiments have examined the pleiotropic effects of adaptation at a snapshot in time, very few have observed the dynamics by which these effects emerge and evolve. Here, we propagated hundreds of diploid and haploid laboratory budding yeast populations in each of three environments, and then assayed their fitness in multiple environments over 1000 generations of evolution. We find that replicate populations evolved in the same condition share common patterns of pleiotropic effects across other environments, which emerge within the first several hundred generations of evolution. However, we also find dynamic and environment-specific variability within these trends: variability in pleiotropic effects tends to increase over time, with the extent of variability depending on the evolution environment. These results suggest shifting and overlapping contributions of chance and contingency to the pleiotropic effects of adaptation, which could influence evolutionary trajectories in complex environments that fluctuate across space and time.
format article
author Christopher W Bakerlee
Angela M Phillips
Alex N Nguyen Ba
Michael M Desai
author_facet Christopher W Bakerlee
Angela M Phillips
Alex N Nguyen Ba
Michael M Desai
author_sort Christopher W Bakerlee
title Dynamics and variability in the pleiotropic effects of adaptation in laboratory budding yeast populations
title_short Dynamics and variability in the pleiotropic effects of adaptation in laboratory budding yeast populations
title_full Dynamics and variability in the pleiotropic effects of adaptation in laboratory budding yeast populations
title_fullStr Dynamics and variability in the pleiotropic effects of adaptation in laboratory budding yeast populations
title_full_unstemmed Dynamics and variability in the pleiotropic effects of adaptation in laboratory budding yeast populations
title_sort dynamics and variability in the pleiotropic effects of adaptation in laboratory budding yeast populations
publisher eLife Sciences Publications Ltd
publishDate 2021
url https://doaj.org/article/11f5bf11feae423aa676a36ecff8e924
work_keys_str_mv AT christopherwbakerlee dynamicsandvariabilityinthepleiotropiceffectsofadaptationinlaboratorybuddingyeastpopulations
AT angelamphillips dynamicsandvariabilityinthepleiotropiceffectsofadaptationinlaboratorybuddingyeastpopulations
AT alexnnguyenba dynamicsandvariabilityinthepleiotropiceffectsofadaptationinlaboratorybuddingyeastpopulations
AT michaelmdesai dynamicsandvariabilityinthepleiotropiceffectsofadaptationinlaboratorybuddingyeastpopulations
_version_ 1718440906796826624