Dynamics and variability in the pleiotropic effects of adaptation in laboratory budding yeast populations

Evolutionary adaptation to a constant environment is driven by the accumulation of mutations which can have a range of unrealized pleiotropic effects in other environments. These pleiotropic consequences of adaptation can influence the emergence of specialists or generalists, and are critical for ev...

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Autores principales:	Christopher W Bakerlee, Angela M Phillips, Alex N Nguyen Ba, Michael M Desai
Formato:	article
Lenguaje:	EN
Publicado:	eLife Sciences Publications Ltd 2021
Materias:	evolutionary dynamics pleiotropy adaptation Medicine R Science Q Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/11f5bf11feae423aa676a36ecff8e924
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spelling	oai:doaj.org-article:11f5bf11feae423aa676a36ecff8e9242021-11-09T15:53:51ZDynamics and variability in the pleiotropic effects of adaptation in laboratory budding yeast populations10.7554/eLife.709182050-084Xe70918https://doaj.org/article/11f5bf11feae423aa676a36ecff8e9242021-10-01T00:00:00Zhttps://elifesciences.org/articles/70918https://doaj.org/toc/2050-084XEvolutionary adaptation to a constant environment is driven by the accumulation of mutations which can have a range of unrealized pleiotropic effects in other environments. These pleiotropic consequences of adaptation can influence the emergence of specialists or generalists, and are critical for evolution in temporally or spatially fluctuating environments. While many experiments have examined the pleiotropic effects of adaptation at a snapshot in time, very few have observed the dynamics by which these effects emerge and evolve. Here, we propagated hundreds of diploid and haploid laboratory budding yeast populations in each of three environments, and then assayed their fitness in multiple environments over 1000 generations of evolution. We find that replicate populations evolved in the same condition share common patterns of pleiotropic effects across other environments, which emerge within the first several hundred generations of evolution. However, we also find dynamic and environment-specific variability within these trends: variability in pleiotropic effects tends to increase over time, with the extent of variability depending on the evolution environment. These results suggest shifting and overlapping contributions of chance and contingency to the pleiotropic effects of adaptation, which could influence evolutionary trajectories in complex environments that fluctuate across space and time.Christopher W BakerleeAngela M PhillipsAlex N Nguyen BaMichael M DesaieLife Sciences Publications Ltdarticleevolutionary dynamicspleiotropyadaptationMedicineRScienceQBiology (General)QH301-705.5ENeLife, Vol 10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	evolutionary dynamics pleiotropy adaptation Medicine R Science Q Biology (General) QH301-705.5
spellingShingle	evolutionary dynamics pleiotropy adaptation Medicine R Science Q Biology (General) QH301-705.5 Christopher W Bakerlee Angela M Phillips Alex N Nguyen Ba Michael M Desai Dynamics and variability in the pleiotropic effects of adaptation in laboratory budding yeast populations
description	Evolutionary adaptation to a constant environment is driven by the accumulation of mutations which can have a range of unrealized pleiotropic effects in other environments. These pleiotropic consequences of adaptation can influence the emergence of specialists or generalists, and are critical for evolution in temporally or spatially fluctuating environments. While many experiments have examined the pleiotropic effects of adaptation at a snapshot in time, very few have observed the dynamics by which these effects emerge and evolve. Here, we propagated hundreds of diploid and haploid laboratory budding yeast populations in each of three environments, and then assayed their fitness in multiple environments over 1000 generations of evolution. We find that replicate populations evolved in the same condition share common patterns of pleiotropic effects across other environments, which emerge within the first several hundred generations of evolution. However, we also find dynamic and environment-specific variability within these trends: variability in pleiotropic effects tends to increase over time, with the extent of variability depending on the evolution environment. These results suggest shifting and overlapping contributions of chance and contingency to the pleiotropic effects of adaptation, which could influence evolutionary trajectories in complex environments that fluctuate across space and time.
format	article
author	Christopher W Bakerlee Angela M Phillips Alex N Nguyen Ba Michael M Desai
author_facet	Christopher W Bakerlee Angela M Phillips Alex N Nguyen Ba Michael M Desai
author_sort	Christopher W Bakerlee
title	Dynamics and variability in the pleiotropic effects of adaptation in laboratory budding yeast populations
title_short	Dynamics and variability in the pleiotropic effects of adaptation in laboratory budding yeast populations
title_full	Dynamics and variability in the pleiotropic effects of adaptation in laboratory budding yeast populations
title_fullStr	Dynamics and variability in the pleiotropic effects of adaptation in laboratory budding yeast populations
title_full_unstemmed	Dynamics and variability in the pleiotropic effects of adaptation in laboratory budding yeast populations
title_sort	dynamics and variability in the pleiotropic effects of adaptation in laboratory budding yeast populations
publisher	eLife Sciences Publications Ltd
publishDate	2021
url	https://doaj.org/article/11f5bf11feae423aa676a36ecff8e924
work_keys_str_mv	AT christopherwbakerlee dynamicsandvariabilityinthepleiotropiceffectsofadaptationinlaboratorybuddingyeastpopulations AT angelamphillips dynamicsandvariabilityinthepleiotropiceffectsofadaptationinlaboratorybuddingyeastpopulations AT alexnnguyenba dynamicsandvariabilityinthepleiotropiceffectsofadaptationinlaboratorybuddingyeastpopulations AT michaelmdesai dynamicsandvariabilityinthepleiotropiceffectsofadaptationinlaboratorybuddingyeastpopulations
_version_	1718440906796826624

Dynamics and variability in the pleiotropic effects of adaptation in laboratory budding yeast populations

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