Protein malnutrition impairs the immune response and influences the severity of infection in a hamster model of chronic visceral leishmaniasis.

Leishmaniasis remains one of the world's most devastating neglected tropical diseases. It mainly affects developing countries, where it often co-exists with chronic malnutrition, one of the main risk factors for developing the disease. Few studies have been published, however, on the relationsh...

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Autores principales:	Eugenia Carrillo, Maria Angeles Jimenez, Carmen Sanchez, Joana Cunha, Camila Marinelli Martins, Anaiá da Paixão Sevá, Javier Moreno
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/11f6e38852d449b3b046c3addef9f15f
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spelling	oai:doaj.org-article:11f6e38852d449b3b046c3addef9f15f2021-11-18T08:31:09ZProtein malnutrition impairs the immune response and influences the severity of infection in a hamster model of chronic visceral leishmaniasis.1932-620310.1371/journal.pone.0089412https://doaj.org/article/11f6e38852d449b3b046c3addef9f15f2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24586759/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Leishmaniasis remains one of the world's most devastating neglected tropical diseases. It mainly affects developing countries, where it often co-exists with chronic malnutrition, one of the main risk factors for developing the disease. Few studies have been published, however, on the relationship between leishmaniasis progression and malnutrition. The present paper reports the influence of protein malnutrition on the immune response and visceral disease development in adult hamsters infected with Leishmania infantum fed either standard or low protein diets. The low protein diet induced severe malnutrition in these animals, and upon infection with L. infantum 33% had severe visceral leishmaniasis compared to only 8% of animals fed the standard diet. The infected, malnourished animals showed notable leukocyte depletion, mild specific antibody responses, impairment of lymphoproliferation, presence of parasites in blood (16.67% of the hamsters) and significant increase of the splenic parasite burden. Animals fed standard diet suffered agranulocytosis and monocytopenia, but showed stronger specific immune responses and had lower parasite loads than their malnourished counterparts. The present results show that protein malnutrition promotes visceral leishmaniasis and provide clues regarding the mechanisms underlying the impairment of the immune system.Eugenia CarrilloMaria Angeles JimenezCarmen SanchezJoana CunhaCamila Marinelli MartinsAnaiá da Paixão SeváJavier MorenoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 2, p e89412 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Eugenia Carrillo Maria Angeles Jimenez Carmen Sanchez Joana Cunha Camila Marinelli Martins Anaiá da Paixão Sevá Javier Moreno Protein malnutrition impairs the immune response and influences the severity of infection in a hamster model of chronic visceral leishmaniasis.
description	Leishmaniasis remains one of the world's most devastating neglected tropical diseases. It mainly affects developing countries, where it often co-exists with chronic malnutrition, one of the main risk factors for developing the disease. Few studies have been published, however, on the relationship between leishmaniasis progression and malnutrition. The present paper reports the influence of protein malnutrition on the immune response and visceral disease development in adult hamsters infected with Leishmania infantum fed either standard or low protein diets. The low protein diet induced severe malnutrition in these animals, and upon infection with L. infantum 33% had severe visceral leishmaniasis compared to only 8% of animals fed the standard diet. The infected, malnourished animals showed notable leukocyte depletion, mild specific antibody responses, impairment of lymphoproliferation, presence of parasites in blood (16.67% of the hamsters) and significant increase of the splenic parasite burden. Animals fed standard diet suffered agranulocytosis and monocytopenia, but showed stronger specific immune responses and had lower parasite loads than their malnourished counterparts. The present results show that protein malnutrition promotes visceral leishmaniasis and provide clues regarding the mechanisms underlying the impairment of the immune system.
format	article
author	Eugenia Carrillo Maria Angeles Jimenez Carmen Sanchez Joana Cunha Camila Marinelli Martins Anaiá da Paixão Sevá Javier Moreno
author_facet	Eugenia Carrillo Maria Angeles Jimenez Carmen Sanchez Joana Cunha Camila Marinelli Martins Anaiá da Paixão Sevá Javier Moreno
author_sort	Eugenia Carrillo
title	Protein malnutrition impairs the immune response and influences the severity of infection in a hamster model of chronic visceral leishmaniasis.
title_short	Protein malnutrition impairs the immune response and influences the severity of infection in a hamster model of chronic visceral leishmaniasis.
title_full	Protein malnutrition impairs the immune response and influences the severity of infection in a hamster model of chronic visceral leishmaniasis.
title_fullStr	Protein malnutrition impairs the immune response and influences the severity of infection in a hamster model of chronic visceral leishmaniasis.
title_full_unstemmed	Protein malnutrition impairs the immune response and influences the severity of infection in a hamster model of chronic visceral leishmaniasis.
title_sort	protein malnutrition impairs the immune response and influences the severity of infection in a hamster model of chronic visceral leishmaniasis.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/11f6e38852d449b3b046c3addef9f15f
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Protein malnutrition impairs the immune response and influences the severity of infection in a hamster model of chronic visceral leishmaniasis.

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