Experimental Oronasal Transmission of Chronic Wasting Disease Agent from White-Tailed Deer to Suffolk Sheep

Chronic wasting disease (CWD) is a fatal prion disease of cervids. We examined host range of CWD by oronasally inoculating Suffolk sheep with brain homogenate from a CWD-positive white-tailed deer. Sixty months after inoculation, 1/7 sheep had immunoreactivity against the misfolded form of prion pr...

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Autores principales:	Eric D. Cassmann, S. Jo Moore, Justin J. Greenlee
Formato:	article
Lenguaje:	EN
Publicado:	Centers for Disease Control and Prevention 2021
Materias:	chronic wasting disease CWD chronic wasting disease agent prions and related diseases transmissible spongiform encephalopathies animal diseases Medicine R Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/11f9a890ba1346c78cc564c2c4ba0537
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spelling	oai:doaj.org-article:11f9a890ba1346c78cc564c2c4ba05372021-11-22T12:58:34ZExperimental Oronasal Transmission of Chronic Wasting Disease Agent from White-Tailed Deer to Suffolk Sheep10.3201/eid2712.2049781080-60401080-6059https://doaj.org/article/11f9a890ba1346c78cc564c2c4ba05372021-12-01T00:00:00Zhttps://wwwnc.cdc.gov/eid/article/27/12/20-4978_articlehttps://doaj.org/toc/1080-6040https://doaj.org/toc/1080-6059 Chronic wasting disease (CWD) is a fatal prion disease of cervids. We examined host range of CWD by oronasally inoculating Suffolk sheep with brain homogenate from a CWD-positive white-tailed deer. Sixty months after inoculation, 1/7 sheep had immunoreactivity against the misfolded form of prion protein in lymphoid tissue. Results were confirmed by mouse bioassay. Eric D. CassmannS. Jo MooreJustin J. GreenleeCenters for Disease Control and Preventionarticlechronic wasting diseaseCWDchronic wasting disease agentprions and related diseasestransmissible spongiform encephalopathiesanimal diseasesMedicineRInfectious and parasitic diseasesRC109-216ENEmerging Infectious Diseases, Vol 27, Iss 12, Pp 3156-3158 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	chronic wasting disease CWD chronic wasting disease agent prions and related diseases transmissible spongiform encephalopathies animal diseases Medicine R Infectious and parasitic diseases RC109-216
spellingShingle	chronic wasting disease CWD chronic wasting disease agent prions and related diseases transmissible spongiform encephalopathies animal diseases Medicine R Infectious and parasitic diseases RC109-216 Eric D. Cassmann S. Jo Moore Justin J. Greenlee Experimental Oronasal Transmission of Chronic Wasting Disease Agent from White-Tailed Deer to Suffolk Sheep
description	Chronic wasting disease (CWD) is a fatal prion disease of cervids. We examined host range of CWD by oronasally inoculating Suffolk sheep with brain homogenate from a CWD-positive white-tailed deer. Sixty months after inoculation, 1/7 sheep had immunoreactivity against the misfolded form of prion protein in lymphoid tissue. Results were confirmed by mouse bioassay.
format	article
author	Eric D. Cassmann S. Jo Moore Justin J. Greenlee
author_facet	Eric D. Cassmann S. Jo Moore Justin J. Greenlee
author_sort	Eric D. Cassmann
title	Experimental Oronasal Transmission of Chronic Wasting Disease Agent from White-Tailed Deer to Suffolk Sheep
title_short	Experimental Oronasal Transmission of Chronic Wasting Disease Agent from White-Tailed Deer to Suffolk Sheep
title_full	Experimental Oronasal Transmission of Chronic Wasting Disease Agent from White-Tailed Deer to Suffolk Sheep
title_fullStr	Experimental Oronasal Transmission of Chronic Wasting Disease Agent from White-Tailed Deer to Suffolk Sheep
title_full_unstemmed	Experimental Oronasal Transmission of Chronic Wasting Disease Agent from White-Tailed Deer to Suffolk Sheep
title_sort	experimental oronasal transmission of chronic wasting disease agent from white-tailed deer to suffolk sheep
publisher	Centers for Disease Control and Prevention
publishDate	2021
url	https://doaj.org/article/11f9a890ba1346c78cc564c2c4ba0537
work_keys_str_mv	AT ericdcassmann experimentaloronasaltransmissionofchronicwastingdiseaseagentfromwhitetaileddeertosuffolksheep AT sjomoore experimentaloronasaltransmissionofchronicwastingdiseaseagentfromwhitetaileddeertosuffolksheep AT justinjgreenlee experimentaloronasaltransmissionofchronicwastingdiseaseagentfromwhitetaileddeertosuffolksheep
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Experimental Oronasal Transmission of Chronic Wasting Disease Agent from White-Tailed Deer to Suffolk Sheep

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