Niacin increases adiponectin and decreases adipose tissue inflammation in high fat diet-fed mice.

<h4>Aims</h4>To determine the effects of niacin on adiponectin and markers of adipose tissue inflammation in a mouse model of obesity.<h4>Materials and methods</h4>Male C57BL/6 mice were placed on a control or high-fat diet (HFD) and were maintained on such diets for the dura...

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Autores principales:	Desiree Wanders, Emily C Graff, B Douglas White, Robert L Judd
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/11fb98ce65cd48cbb70f19e7da656cda
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spelling	oai:doaj.org-article:11fb98ce65cd48cbb70f19e7da656cda2021-11-18T08:59:54ZNiacin increases adiponectin and decreases adipose tissue inflammation in high fat diet-fed mice.1932-620310.1371/journal.pone.0071285https://doaj.org/article/11fb98ce65cd48cbb70f19e7da656cda2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23967184/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Aims</h4>To determine the effects of niacin on adiponectin and markers of adipose tissue inflammation in a mouse model of obesity.<h4>Materials and methods</h4>Male C57BL/6 mice were placed on a control or high-fat diet (HFD) and were maintained on such diets for the duration of the study. After 6 weeks on the control or high fat diets, vehicle or niacin treatments were initiated and maintained for 5 weeks. Identical studies were conducted concurrently in HCA2 (-/-) (niacin receptor(-/-)) mice.<h4>Results</h4>Niacin increased serum concentrations of the anti-inflammatory adipokine, adiponectin by 21% in HFD-fed wild-type mice, but had no effect on lean wild-type or lean or HFD-fed HCA2 (-/-) mice. Niacin increased adiponectin gene and protein expression in the HFD-fed wild-type mice only. The increases in adiponectin serum concentrations, gene and protein expression occurred independently of changes in expression of PPARγ C/EBPα or SREBP-1c (key transcription factors known to positively regulate adiponectin gene transcription) in the adipose tissue. Further, niacin had no effect on adipose tissue expression of ERp44, Ero1-Lα, or DsbA-L (key ER chaperones involved in adiponectin production and secretion). However, niacin treatment attenuated HFD-induced increases in adipose tissue gene expression of MCP-1 and IL-1β in the wild-type HFD-fed mice. Niacin also reduced the expression of the pro-inflammatory M1 macrophage marker CD11c in HFD-fed wild-type mice.<h4>Conclusions</h4>Niacin treatment attenuates obesity-induced adipose tissue inflammation through increased adiponectin and anti-inflammatory cytokine expression and reduced pro-inflammatory cytokine expression in a niacin receptor-dependent manner.Desiree WandersEmily C GraffB Douglas WhiteRobert L JuddPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 8, p e71285 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Desiree Wanders Emily C Graff B Douglas White Robert L Judd Niacin increases adiponectin and decreases adipose tissue inflammation in high fat diet-fed mice.
description	<h4>Aims</h4>To determine the effects of niacin on adiponectin and markers of adipose tissue inflammation in a mouse model of obesity.<h4>Materials and methods</h4>Male C57BL/6 mice were placed on a control or high-fat diet (HFD) and were maintained on such diets for the duration of the study. After 6 weeks on the control or high fat diets, vehicle or niacin treatments were initiated and maintained for 5 weeks. Identical studies were conducted concurrently in HCA2 (-/-) (niacin receptor(-/-)) mice.<h4>Results</h4>Niacin increased serum concentrations of the anti-inflammatory adipokine, adiponectin by 21% in HFD-fed wild-type mice, but had no effect on lean wild-type or lean or HFD-fed HCA2 (-/-) mice. Niacin increased adiponectin gene and protein expression in the HFD-fed wild-type mice only. The increases in adiponectin serum concentrations, gene and protein expression occurred independently of changes in expression of PPARγ C/EBPα or SREBP-1c (key transcription factors known to positively regulate adiponectin gene transcription) in the adipose tissue. Further, niacin had no effect on adipose tissue expression of ERp44, Ero1-Lα, or DsbA-L (key ER chaperones involved in adiponectin production and secretion). However, niacin treatment attenuated HFD-induced increases in adipose tissue gene expression of MCP-1 and IL-1β in the wild-type HFD-fed mice. Niacin also reduced the expression of the pro-inflammatory M1 macrophage marker CD11c in HFD-fed wild-type mice.<h4>Conclusions</h4>Niacin treatment attenuates obesity-induced adipose tissue inflammation through increased adiponectin and anti-inflammatory cytokine expression and reduced pro-inflammatory cytokine expression in a niacin receptor-dependent manner.
format	article
author	Desiree Wanders Emily C Graff B Douglas White Robert L Judd
author_facet	Desiree Wanders Emily C Graff B Douglas White Robert L Judd
author_sort	Desiree Wanders
title	Niacin increases adiponectin and decreases adipose tissue inflammation in high fat diet-fed mice.
title_short	Niacin increases adiponectin and decreases adipose tissue inflammation in high fat diet-fed mice.
title_full	Niacin increases adiponectin and decreases adipose tissue inflammation in high fat diet-fed mice.
title_fullStr	Niacin increases adiponectin and decreases adipose tissue inflammation in high fat diet-fed mice.
title_full_unstemmed	Niacin increases adiponectin and decreases adipose tissue inflammation in high fat diet-fed mice.
title_sort	niacin increases adiponectin and decreases adipose tissue inflammation in high fat diet-fed mice.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/11fb98ce65cd48cbb70f19e7da656cda
work_keys_str_mv	AT desireewanders niacinincreasesadiponectinanddecreasesadiposetissueinflammationinhighfatdietfedmice AT emilycgraff niacinincreasesadiponectinanddecreasesadiposetissueinflammationinhighfatdietfedmice AT bdouglaswhite niacinincreasesadiponectinanddecreasesadiposetissueinflammationinhighfatdietfedmice AT robertljudd niacinincreasesadiponectinanddecreasesadiposetissueinflammationinhighfatdietfedmice
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Niacin increases adiponectin and decreases adipose tissue inflammation in high fat diet-fed mice.

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