Wireless MRI Colonoscopy for Sensitive Imaging of Vascular Walls

Abstract A Wireless Amplified NMR Detector (WAND) with cylindrical symmetry has been fabricated and non-surgically inserted into a rodent lower digestive track to improve the imaging quality of deep-lying vessels inside the abdominal cavity. This symmetric detector has a compact design using two end...

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Autores principales:	Xianchun Zeng, Liangliang Chen, Chuan Wang, Jian Wang, Chunqi Qian
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/11fc917f243f4118a26b35be6cc6ebcd
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spelling	oai:doaj.org-article:11fc917f243f4118a26b35be6cc6ebcd2021-12-02T11:41:11ZWireless MRI Colonoscopy for Sensitive Imaging of Vascular Walls10.1038/s41598-017-03902-72045-2322https://doaj.org/article/11fc917f243f4118a26b35be6cc6ebcd2017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03902-7https://doaj.org/toc/2045-2322Abstract A Wireless Amplified NMR Detector (WAND) with cylindrical symmetry has been fabricated and non-surgically inserted into a rodent lower digestive track to improve the imaging quality of deep-lying vessels inside the abdominal cavity. This symmetric detector has a compact design using two end-rings and two vertical legs to create two orthogonal resonance modes. Based on the principle of parametric amplification, the detector can harvest wireless pumping power with its end-rings and amplify Magnetic Resonance signals induced on its vertical legs. With good longitudinal and azimuthal homogeneity, the WAND can achieve up to 21-times sensitivity gain over a standard external detector for immediately adjacent regions, and at least 5-times sensitivity gain for regions separated by one diameter away from the detector’s cylindrical surface. The WAND can approach the region of interest through the lower digestive track, similar as a colonoscopy detector. But unlike an optical camera, the amplified MR detector can “see” across intestinal boundaries and clearly identify the walls of bifurcated vessels that are susceptible to atherosclerotic lesions. In addition to vascular wall imaging, this detector may also be used as a swallowable capsule to enhance the detection sensitivity of deep-lying organs near the digestive track.Xianchun ZengLiangliang ChenChuan WangJian WangChunqi QianNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xianchun Zeng Liangliang Chen Chuan Wang Jian Wang Chunqi Qian Wireless MRI Colonoscopy for Sensitive Imaging of Vascular Walls
description	Abstract A Wireless Amplified NMR Detector (WAND) with cylindrical symmetry has been fabricated and non-surgically inserted into a rodent lower digestive track to improve the imaging quality of deep-lying vessels inside the abdominal cavity. This symmetric detector has a compact design using two end-rings and two vertical legs to create two orthogonal resonance modes. Based on the principle of parametric amplification, the detector can harvest wireless pumping power with its end-rings and amplify Magnetic Resonance signals induced on its vertical legs. With good longitudinal and azimuthal homogeneity, the WAND can achieve up to 21-times sensitivity gain over a standard external detector for immediately adjacent regions, and at least 5-times sensitivity gain for regions separated by one diameter away from the detector’s cylindrical surface. The WAND can approach the region of interest through the lower digestive track, similar as a colonoscopy detector. But unlike an optical camera, the amplified MR detector can “see” across intestinal boundaries and clearly identify the walls of bifurcated vessels that are susceptible to atherosclerotic lesions. In addition to vascular wall imaging, this detector may also be used as a swallowable capsule to enhance the detection sensitivity of deep-lying organs near the digestive track.
format	article
author	Xianchun Zeng Liangliang Chen Chuan Wang Jian Wang Chunqi Qian
author_facet	Xianchun Zeng Liangliang Chen Chuan Wang Jian Wang Chunqi Qian
author_sort	Xianchun Zeng
title	Wireless MRI Colonoscopy for Sensitive Imaging of Vascular Walls
title_short	Wireless MRI Colonoscopy for Sensitive Imaging of Vascular Walls
title_full	Wireless MRI Colonoscopy for Sensitive Imaging of Vascular Walls
title_fullStr	Wireless MRI Colonoscopy for Sensitive Imaging of Vascular Walls
title_full_unstemmed	Wireless MRI Colonoscopy for Sensitive Imaging of Vascular Walls
title_sort	wireless mri colonoscopy for sensitive imaging of vascular walls
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/11fc917f243f4118a26b35be6cc6ebcd
work_keys_str_mv	AT xianchunzeng wirelessmricolonoscopyforsensitiveimagingofvascularwalls AT liangliangchen wirelessmricolonoscopyforsensitiveimagingofvascularwalls AT chuanwang wirelessmricolonoscopyforsensitiveimagingofvascularwalls AT jianwang wirelessmricolonoscopyforsensitiveimagingofvascularwalls AT chunqiqian wirelessmricolonoscopyforsensitiveimagingofvascularwalls
_version_	1718395445229649920

Wireless MRI Colonoscopy for Sensitive Imaging of Vascular Walls

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