PHENOTYPE AND FUNCTIONS OF DENDRITIC CELLS IN PATIENTS WITH CHRONIC VIRAL HEPATITIS

Abstract. Phenotypic and functional features of IFNα-induced dendritic cells (DCs) were studied in patients with chronic viral hepatitis B and C (HBV and HCV), and in cases with hepatitis-related liver cirrhosis (LC). It was shown that DCs are characterized by delayed differentiation/maturation whic...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	O. Yu. Leplina, M. A. Tikhonova, A. E. Borisova, N. M. Starostina, A. A. Ostanin, E. R. Chernykh, V. A. Kozlov
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	viral hepatitis b viral hepatitis c dendritic cells cytokines liver cirrhosis Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/120147efe57d4545b50dcb8c5e7d4383
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:120147efe57d4545b50dcb8c5e7d4383
record_format	dspace
spelling	oai:doaj.org-article:120147efe57d4545b50dcb8c5e7d43832021-11-18T08:03:40ZPHENOTYPE AND FUNCTIONS OF DENDRITIC CELLS IN PATIENTS WITH CHRONIC VIRAL HEPATITIS1563-06252313-741X10.15789/1563-0625-2009-2-3-191-196https://doaj.org/article/120147efe57d4545b50dcb8c5e7d43832014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/291https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Phenotypic and functional features of IFNα-induced dendritic cells (DCs) were studied in patients with chronic viral hepatitis B and C (HBV and HCV), and in cases with hepatitis-related liver cirrhosis (LC). It was shown that DCs are characterized by delayed differentiation/maturation which was more pronounced in HCV patients, as well as in all patients with LC, regardless of virus type. DCs from HBV patients were characterized by increased IFNγ secretion. Transformation of HBV-infection to LC is accompanied by a moderate decrease in IFNγ production, combined with a significantly increased IL-10 secretion. Irrespectively of fibrosis severity, the IFNα-induced DCs of HCV patients displayed active IL-10 synthesis. Moreover, ability of DCs to secrete IFNγ was significantly decreased only in cases of fibrosis-complicated HCV-infection. With respect to TNFα and IL-4 production levels, DCs of the patients were compatibe to normal donor cells, independently on the type of virus, or fibrosis severity. DCs from HBV- and HCV-patients were characterized by intact allostimulatory and Th1/Th2-stimulatory activities in MLC. At the same time, IFNα-induced DCs exhibited suppression of allostimulatory and increase in Th2-polarizing activity upon LC development, both in HBV and HCV patients.O. Yu. LeplinaM. A. TikhonovaA. E. BorisovaN. M. StarostinaA. A. OstaninE. R. ChernykhV. A. KozlovSPb RAACIarticleviral hepatitis bviral hepatitis cdendritic cellscytokinesliver cirrhosisImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 11, Iss 2-3, Pp 191-196 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	viral hepatitis b viral hepatitis c dendritic cells cytokines liver cirrhosis Immunologic diseases. Allergy RC581-607
spellingShingle	viral hepatitis b viral hepatitis c dendritic cells cytokines liver cirrhosis Immunologic diseases. Allergy RC581-607 O. Yu. Leplina M. A. Tikhonova A. E. Borisova N. M. Starostina A. A. Ostanin E. R. Chernykh V. A. Kozlov PHENOTYPE AND FUNCTIONS OF DENDRITIC CELLS IN PATIENTS WITH CHRONIC VIRAL HEPATITIS
description	Abstract. Phenotypic and functional features of IFNα-induced dendritic cells (DCs) were studied in patients with chronic viral hepatitis B and C (HBV and HCV), and in cases with hepatitis-related liver cirrhosis (LC). It was shown that DCs are characterized by delayed differentiation/maturation which was more pronounced in HCV patients, as well as in all patients with LC, regardless of virus type. DCs from HBV patients were characterized by increased IFNγ secretion. Transformation of HBV-infection to LC is accompanied by a moderate decrease in IFNγ production, combined with a significantly increased IL-10 secretion. Irrespectively of fibrosis severity, the IFNα-induced DCs of HCV patients displayed active IL-10 synthesis. Moreover, ability of DCs to secrete IFNγ was significantly decreased only in cases of fibrosis-complicated HCV-infection. With respect to TNFα and IL-4 production levels, DCs of the patients were compatibe to normal donor cells, independently on the type of virus, or fibrosis severity. DCs from HBV- and HCV-patients were characterized by intact allostimulatory and Th1/Th2-stimulatory activities in MLC. At the same time, IFNα-induced DCs exhibited suppression of allostimulatory and increase in Th2-polarizing activity upon LC development, both in HBV and HCV patients.
format	article
author	O. Yu. Leplina M. A. Tikhonova A. E. Borisova N. M. Starostina A. A. Ostanin E. R. Chernykh V. A. Kozlov
author_facet	O. Yu. Leplina M. A. Tikhonova A. E. Borisova N. M. Starostina A. A. Ostanin E. R. Chernykh V. A. Kozlov
author_sort	O. Yu. Leplina
title	PHENOTYPE AND FUNCTIONS OF DENDRITIC CELLS IN PATIENTS WITH CHRONIC VIRAL HEPATITIS
title_short	PHENOTYPE AND FUNCTIONS OF DENDRITIC CELLS IN PATIENTS WITH CHRONIC VIRAL HEPATITIS
title_full	PHENOTYPE AND FUNCTIONS OF DENDRITIC CELLS IN PATIENTS WITH CHRONIC VIRAL HEPATITIS
title_fullStr	PHENOTYPE AND FUNCTIONS OF DENDRITIC CELLS IN PATIENTS WITH CHRONIC VIRAL HEPATITIS
title_full_unstemmed	PHENOTYPE AND FUNCTIONS OF DENDRITIC CELLS IN PATIENTS WITH CHRONIC VIRAL HEPATITIS
title_sort	phenotype and functions of dendritic cells in patients with chronic viral hepatitis
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/120147efe57d4545b50dcb8c5e7d4383
work_keys_str_mv	AT oyuleplina phenotypeandfunctionsofdendriticcellsinpatientswithchronicviralhepatitis AT matikhonova phenotypeandfunctionsofdendriticcellsinpatientswithchronicviralhepatitis AT aeborisova phenotypeandfunctionsofdendriticcellsinpatientswithchronicviralhepatitis AT nmstarostina phenotypeandfunctionsofdendriticcellsinpatientswithchronicviralhepatitis AT aaostanin phenotypeandfunctionsofdendriticcellsinpatientswithchronicviralhepatitis AT erchernykh phenotypeandfunctionsofdendriticcellsinpatientswithchronicviralhepatitis AT vakozlov phenotypeandfunctionsofdendriticcellsinpatientswithchronicviralhepatitis
_version_	1718422525988306944

PHENOTYPE AND FUNCTIONS OF DENDRITIC CELLS IN PATIENTS WITH CHRONIC VIRAL HEPATITIS

Ejemplares similares