Interdependence of metals and its binding proteins in Parkinson’s disease for diagnosis

Abstract Metalloproteins utilizes cellular metals which plays a crucial function in brain that linked with neurodegenerative disorders. Parkinson’s disease (PD) is a neurodegenerative disorder that affects geriatric population world-wide. Twenty-four metal-binding protein networks were investigated...

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Autores principales:	Athira Anirudhan, Paramasivam Prabu, Jaya Sanyal, Tapas Kumar Banerjee, Gautam Guha, Ram Murugesan, Shiek S. S. J. Ahmed
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/120326f14e744f56ab2bc8fa798bf5cd
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spelling	oai:doaj.org-article:120326f14e744f56ab2bc8fa798bf5cd2021-12-02T15:13:03ZInterdependence of metals and its binding proteins in Parkinson’s disease for diagnosis10.1038/s41531-020-00146-72373-8057https://doaj.org/article/120326f14e744f56ab2bc8fa798bf5cd2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41531-020-00146-7https://doaj.org/toc/2373-8057Abstract Metalloproteins utilizes cellular metals which plays a crucial function in brain that linked with neurodegenerative disorders. Parkinson’s disease (PD) is a neurodegenerative disorder that affects geriatric population world-wide. Twenty-four metal-binding protein networks were investigated to identify key regulating protein hubs in PD blood and brain. Amongst, aluminum, calcium, copper, iron, and magnesium protein hubs are the key regulators showing the ability to classify PD from control based on thirty-four classification algorithms. Analysis of these five metal proteins hubs showed involvement in environmental information processing, immune, neuronal, endocrine, aging, and signal transduction pathways. Furthermore, gene expression of functional protein in each hub showed significant upregulation of EFEMP2, MMP9, B2M, MEAF2A, and TARDBP in PD. Dysregulating hub proteins imprint the metal availability in a biological system. Hence, metal concentration in serum and cerebrospinal fluid were tested, which were altered and showed significant contribution towards gene expression of metal hub proteins along with the previously reported PD markers. In conclusion, analyzing the levels of serum metals along with the gene expression in PD opens up an ideal and feasible diagnostic intervention for PD. Hence, this will be a cost effective and rapid method for the detection of Parkinson’s disease.Athira AnirudhanParamasivam PrabuJaya SanyalTapas Kumar BanerjeeGautam GuhaRam MurugesanShiek S. S. J. AhmedNature PortfolioarticleNeurology. Diseases of the nervous systemRC346-429ENnpj Parkinson's Disease, Vol 7, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurology. Diseases of the nervous system RC346-429 Athira Anirudhan Paramasivam Prabu Jaya Sanyal Tapas Kumar Banerjee Gautam Guha Ram Murugesan Shiek S. S. J. Ahmed Interdependence of metals and its binding proteins in Parkinson’s disease for diagnosis
description	Abstract Metalloproteins utilizes cellular metals which plays a crucial function in brain that linked with neurodegenerative disorders. Parkinson’s disease (PD) is a neurodegenerative disorder that affects geriatric population world-wide. Twenty-four metal-binding protein networks were investigated to identify key regulating protein hubs in PD blood and brain. Amongst, aluminum, calcium, copper, iron, and magnesium protein hubs are the key regulators showing the ability to classify PD from control based on thirty-four classification algorithms. Analysis of these five metal proteins hubs showed involvement in environmental information processing, immune, neuronal, endocrine, aging, and signal transduction pathways. Furthermore, gene expression of functional protein in each hub showed significant upregulation of EFEMP2, MMP9, B2M, MEAF2A, and TARDBP in PD. Dysregulating hub proteins imprint the metal availability in a biological system. Hence, metal concentration in serum and cerebrospinal fluid were tested, which were altered and showed significant contribution towards gene expression of metal hub proteins along with the previously reported PD markers. In conclusion, analyzing the levels of serum metals along with the gene expression in PD opens up an ideal and feasible diagnostic intervention for PD. Hence, this will be a cost effective and rapid method for the detection of Parkinson’s disease.
format	article
author	Athira Anirudhan Paramasivam Prabu Jaya Sanyal Tapas Kumar Banerjee Gautam Guha Ram Murugesan Shiek S. S. J. Ahmed
author_facet	Athira Anirudhan Paramasivam Prabu Jaya Sanyal Tapas Kumar Banerjee Gautam Guha Ram Murugesan Shiek S. S. J. Ahmed
author_sort	Athira Anirudhan
title	Interdependence of metals and its binding proteins in Parkinson’s disease for diagnosis
title_short	Interdependence of metals and its binding proteins in Parkinson’s disease for diagnosis
title_full	Interdependence of metals and its binding proteins in Parkinson’s disease for diagnosis
title_fullStr	Interdependence of metals and its binding proteins in Parkinson’s disease for diagnosis
title_full_unstemmed	Interdependence of metals and its binding proteins in Parkinson’s disease for diagnosis
title_sort	interdependence of metals and its binding proteins in parkinson’s disease for diagnosis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/120326f14e744f56ab2bc8fa798bf5cd
work_keys_str_mv	AT athiraanirudhan interdependenceofmetalsanditsbindingproteinsinparkinsonsdiseasefordiagnosis AT paramasivamprabu interdependenceofmetalsanditsbindingproteinsinparkinsonsdiseasefordiagnosis AT jayasanyal interdependenceofmetalsanditsbindingproteinsinparkinsonsdiseasefordiagnosis AT tapaskumarbanerjee interdependenceofmetalsanditsbindingproteinsinparkinsonsdiseasefordiagnosis AT gautamguha interdependenceofmetalsanditsbindingproteinsinparkinsonsdiseasefordiagnosis AT rammurugesan interdependenceofmetalsanditsbindingproteinsinparkinsonsdiseasefordiagnosis AT shiekssjahmed interdependenceofmetalsanditsbindingproteinsinparkinsonsdiseasefordiagnosis
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Interdependence of metals and its binding proteins in Parkinson’s disease for diagnosis

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