Squamous cell carcinoma of the nail unit

Squamous cell carcinoma (SCC) of the nail apparatus is a rare malignant tumor that usually originates underneath the nail plate and grows slowly with possible bone invasion. The etiology remains unknown, although a strong association with different conditions, such as high-risk human papillomavirus...

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Autores principales:	Michela Starace, Aurora Alessandrini, Emi Dika, Bianca Maria Piraccini
Formato:	article
Lenguaje:	EN
Publicado:	Mattioli1885 2018
Materias:	squamous cell carcinoma malignant nail tumor nail surgery nail unit onychoscopy Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/120380e29b464d3db77a7a332f391d26
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spelling	oai:doaj.org-article:120380e29b464d3db77a7a332f391d262021-11-17T08:30:04ZSquamous cell carcinoma of the nail unit2160-9381https://doaj.org/article/120380e29b464d3db77a7a332f391d262018-07-01T00:00:00Zhttp://dpcj.org/index.php/dpc/article/view/455https://doaj.org/toc/2160-9381 Squamous cell carcinoma (SCC) of the nail apparatus is a rare malignant tumor that usually originates underneath the nail plate and grows slowly with possible bone invasion. The etiology remains unknown, although a strong association with different conditions, such as high-risk human papillomavirus (HPVs), trauma, or radiation exposure has been demonstrated. Nail SCC is called “the great mimicker nail tumor” because different clinical presentations may coexist, resembling benign or malignant nail lesions. For this reason, there is often a significant delay between the onset of nail SCC and the diagnosis. Clinical manifestation includes onycholysis and erythema, while in the advanced stages nail ulceration can be observed. The association with pain, swelling, and inflammation usually indicates an invasive SCC with involvement of the underlying bone. Metastasis is rare but possible with involvement of lymph nodes. A multidisciplinary approach to assessment, management, and follow-up is advised. Using careful examination and modern diagnostic methods, including onychoscopy, biopsy, and histopathology, will help identify SCC and prevent the invasive progression. X-ray is important to investigate the bone invasion to determine the best surgical approach that will have satisfying cosmetic and functional outcomes. Nevertheless, local excision with sufficient surgical margins, best if using Mohs surgery, is usually sufficient and superior to amputation of the distal phalanx. This review aims to highlight the correct approach in suspected SCC of the nail unit. Michela StaraceAurora AlessandriniEmi DikaBianca Maria PiracciniMattioli1885articlesquamous cell carcinomamalignant nail tumornail surgerynail unitonychoscopyDermatologyRL1-803ENDermatology Practical & Conceptual, Vol 8, Iss 3 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	squamous cell carcinoma malignant nail tumor nail surgery nail unit onychoscopy Dermatology RL1-803
spellingShingle	squamous cell carcinoma malignant nail tumor nail surgery nail unit onychoscopy Dermatology RL1-803 Michela Starace Aurora Alessandrini Emi Dika Bianca Maria Piraccini Squamous cell carcinoma of the nail unit
description	Squamous cell carcinoma (SCC) of the nail apparatus is a rare malignant tumor that usually originates underneath the nail plate and grows slowly with possible bone invasion. The etiology remains unknown, although a strong association with different conditions, such as high-risk human papillomavirus (HPVs), trauma, or radiation exposure has been demonstrated. Nail SCC is called “the great mimicker nail tumor” because different clinical presentations may coexist, resembling benign or malignant nail lesions. For this reason, there is often a significant delay between the onset of nail SCC and the diagnosis. Clinical manifestation includes onycholysis and erythema, while in the advanced stages nail ulceration can be observed. The association with pain, swelling, and inflammation usually indicates an invasive SCC with involvement of the underlying bone. Metastasis is rare but possible with involvement of lymph nodes. A multidisciplinary approach to assessment, management, and follow-up is advised. Using careful examination and modern diagnostic methods, including onychoscopy, biopsy, and histopathology, will help identify SCC and prevent the invasive progression. X-ray is important to investigate the bone invasion to determine the best surgical approach that will have satisfying cosmetic and functional outcomes. Nevertheless, local excision with sufficient surgical margins, best if using Mohs surgery, is usually sufficient and superior to amputation of the distal phalanx. This review aims to highlight the correct approach in suspected SCC of the nail unit.
format	article
author	Michela Starace Aurora Alessandrini Emi Dika Bianca Maria Piraccini
author_facet	Michela Starace Aurora Alessandrini Emi Dika Bianca Maria Piraccini
author_sort	Michela Starace
title	Squamous cell carcinoma of the nail unit
title_short	Squamous cell carcinoma of the nail unit
title_full	Squamous cell carcinoma of the nail unit
title_fullStr	Squamous cell carcinoma of the nail unit
title_full_unstemmed	Squamous cell carcinoma of the nail unit
title_sort	squamous cell carcinoma of the nail unit
publisher	Mattioli1885
publishDate	2018
url	https://doaj.org/article/120380e29b464d3db77a7a332f391d26
work_keys_str_mv	AT michelastarace squamouscellcarcinomaofthenailunit AT auroraalessandrini squamouscellcarcinomaofthenailunit AT emidika squamouscellcarcinomaofthenailunit AT biancamariapiraccini squamouscellcarcinomaofthenailunit
_version_	1718425719460069376

Squamous cell carcinoma of the nail unit

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