Hydroxyurea Induces Bone Marrow Mesenchymal Stromal Cells Senescence and Modifies Cell Functionality In Vitro
Hydroxyurea (HU) is an antineoplastic agent that functions as an antimetabolite compound by inhibiting the ribonucleotide reductase. HU acts mainly as a cytostatic drug that through DNA replication stress may trigger a premature senescence-like cell phenotype, though its influence on bone marrow-der...
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Autores principales: | Sunčica Kapor, Milica Vukotić, Tijana Subotički, Dragoslava Đikić, Olivera Mitrović Ajtić, Milica Radojković, Vladan P. Čokić, Juan F. Santibanez |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
MDPI AG
2021
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Materias: | |
Acceso en línea: | https://doaj.org/article/12042089d7074df19c9805d4a519fb13 |
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