The distinctive structure and composition of arterial and venous thrombi and pulmonary emboli

Abstract Although arterial and venous thromboembolic disorders are among the most frequent causes of mortality and morbidity, there has been little description of how the composition of thrombi and emboli depends on their vascular origin and age. We quantified the structure and composition of arteri...

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Autores principales:	Irina N. Chernysh, Chandrasekaran Nagaswami, Sofia Kosolapova, Alina D. Peshkova, Adam Cuker, Douglas B. Cines, Carolyn L. Cambor, Rustem I. Litvinov, John W. Weisel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/12086ecd9aa2460989bafb505ae629db
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spelling	oai:doaj.org-article:12086ecd9aa2460989bafb505ae629db2021-12-02T16:30:58ZThe distinctive structure and composition of arterial and venous thrombi and pulmonary emboli10.1038/s41598-020-59526-x2045-2322https://doaj.org/article/12086ecd9aa2460989bafb505ae629db2020-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-59526-xhttps://doaj.org/toc/2045-2322Abstract Although arterial and venous thromboembolic disorders are among the most frequent causes of mortality and morbidity, there has been little description of how the composition of thrombi and emboli depends on their vascular origin and age. We quantified the structure and composition of arterial and venous thrombi and pulmonary emboli using high-resolution scanning electron microscopy. Arterial thrombi contained a surprisingly large amount of fibrin, in addition to platelets. The composition of pulmonary emboli mirrored the most distal part of venous thrombi from which they originated, which differed from the structure of the body and head of the same thrombi. All thrombi and emboli contained few biconcave red blood cells but many polyhedrocytes or related forms of compressed red blood cells, demonstrating that these structures are a signature of clot contraction in vivo. Polyhedrocytes and intermediate forms comprised the major constituents of venous thrombi and pulmonary emboli. The structures within all of the thrombi and emboli were very tightly packed, in contrast to clots formed in vitro. There are distinctive, reproducible differences among arterial and venous thrombi and emboli related to their origin, destination and duration, which may have clinical implications for the understanding and treatment of thrombotic disorders.Irina N. ChernyshChandrasekaran NagaswamiSofia KosolapovaAlina D. PeshkovaAdam CukerDouglas B. CinesCarolyn L. CamborRustem I. LitvinovJohn W. WeiselNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Irina N. Chernysh Chandrasekaran Nagaswami Sofia Kosolapova Alina D. Peshkova Adam Cuker Douglas B. Cines Carolyn L. Cambor Rustem I. Litvinov John W. Weisel The distinctive structure and composition of arterial and venous thrombi and pulmonary emboli
description	Abstract Although arterial and venous thromboembolic disorders are among the most frequent causes of mortality and morbidity, there has been little description of how the composition of thrombi and emboli depends on their vascular origin and age. We quantified the structure and composition of arterial and venous thrombi and pulmonary emboli using high-resolution scanning electron microscopy. Arterial thrombi contained a surprisingly large amount of fibrin, in addition to platelets. The composition of pulmonary emboli mirrored the most distal part of venous thrombi from which they originated, which differed from the structure of the body and head of the same thrombi. All thrombi and emboli contained few biconcave red blood cells but many polyhedrocytes or related forms of compressed red blood cells, demonstrating that these structures are a signature of clot contraction in vivo. Polyhedrocytes and intermediate forms comprised the major constituents of venous thrombi and pulmonary emboli. The structures within all of the thrombi and emboli were very tightly packed, in contrast to clots formed in vitro. There are distinctive, reproducible differences among arterial and venous thrombi and emboli related to their origin, destination and duration, which may have clinical implications for the understanding and treatment of thrombotic disorders.
format	article
author	Irina N. Chernysh Chandrasekaran Nagaswami Sofia Kosolapova Alina D. Peshkova Adam Cuker Douglas B. Cines Carolyn L. Cambor Rustem I. Litvinov John W. Weisel
author_facet	Irina N. Chernysh Chandrasekaran Nagaswami Sofia Kosolapova Alina D. Peshkova Adam Cuker Douglas B. Cines Carolyn L. Cambor Rustem I. Litvinov John W. Weisel
author_sort	Irina N. Chernysh
title	The distinctive structure and composition of arterial and venous thrombi and pulmonary emboli
title_short	The distinctive structure and composition of arterial and venous thrombi and pulmonary emboli
title_full	The distinctive structure and composition of arterial and venous thrombi and pulmonary emboli
title_fullStr	The distinctive structure and composition of arterial and venous thrombi and pulmonary emboli
title_full_unstemmed	The distinctive structure and composition of arterial and venous thrombi and pulmonary emboli
title_sort	distinctive structure and composition of arterial and venous thrombi and pulmonary emboli
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/12086ecd9aa2460989bafb505ae629db
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The distinctive structure and composition of arterial and venous thrombi and pulmonary emboli

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