Novel Implications of MicroRNAs, Long Non-coding RNAs and Circular RNAs in Drug Resistance of Esophageal Cancer

Esophageal cancer is the eighth most common malignancy and the sixth leading cause of cancer-related deaths worldwide. Chemotherapy based on platinum drugs, 5-fluorouracil, adriamycin, paclitaxel, gemcitabine, and vinorelbine, as well as targeted treatment and immunotherapy with immune checkpoint in...

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Autores principales:	Ling Wei, Jujie Sun, Nasha Zhang, Yue Shen, Teng Wang, Zengjun Li, Ming Yang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	esophageal cancer drug resistance microRNA long non-coding RNA circular RNA Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/120ec580cf31457798702ef13132b2c7
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spelling	oai:doaj.org-article:120ec580cf31457798702ef13132b2c72021-11-22T06:09:58ZNovel Implications of MicroRNAs, Long Non-coding RNAs and Circular RNAs in Drug Resistance of Esophageal Cancer2296-634X10.3389/fcell.2021.764313https://doaj.org/article/120ec580cf31457798702ef13132b2c72021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.764313/fullhttps://doaj.org/toc/2296-634XEsophageal cancer is the eighth most common malignancy and the sixth leading cause of cancer-related deaths worldwide. Chemotherapy based on platinum drugs, 5-fluorouracil, adriamycin, paclitaxel, gemcitabine, and vinorelbine, as well as targeted treatment and immunotherapy with immune checkpoint inhibitors improved the prognosis in a portion of patients with advanced esophageal cancer. Unfortunately, a number of esophageal cancer patients develop drug resistance, resulting in poor outcomes. Multiple mechanisms contributing to drug resistance of esophageal cancer have been reported. Notably, non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs), have been identified to play crucial roles in modulating esophageal cancer drug resistance. In the present review, we highlight the underlying mechanisms how miRNAs, lncRNAs, and circRNAs impact the drug resistance of esophageal cancer. Several miRNAs, lncRNAs, and circRNAs may have potential clinical implications as novel biomarkers and therapeutic targets for esophageal cancer.Ling WeiJujie SunNasha ZhangYue ShenTeng WangZengjun LiMing YangFrontiers Media S.A.articleesophageal cancerdrug resistancemicroRNAlong non-coding RNAcircular RNABiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	esophageal cancer drug resistance microRNA long non-coding RNA circular RNA Biology (General) QH301-705.5
spellingShingle	esophageal cancer drug resistance microRNA long non-coding RNA circular RNA Biology (General) QH301-705.5 Ling Wei Jujie Sun Nasha Zhang Yue Shen Teng Wang Zengjun Li Ming Yang Novel Implications of MicroRNAs, Long Non-coding RNAs and Circular RNAs in Drug Resistance of Esophageal Cancer
description	Esophageal cancer is the eighth most common malignancy and the sixth leading cause of cancer-related deaths worldwide. Chemotherapy based on platinum drugs, 5-fluorouracil, adriamycin, paclitaxel, gemcitabine, and vinorelbine, as well as targeted treatment and immunotherapy with immune checkpoint inhibitors improved the prognosis in a portion of patients with advanced esophageal cancer. Unfortunately, a number of esophageal cancer patients develop drug resistance, resulting in poor outcomes. Multiple mechanisms contributing to drug resistance of esophageal cancer have been reported. Notably, non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs), have been identified to play crucial roles in modulating esophageal cancer drug resistance. In the present review, we highlight the underlying mechanisms how miRNAs, lncRNAs, and circRNAs impact the drug resistance of esophageal cancer. Several miRNAs, lncRNAs, and circRNAs may have potential clinical implications as novel biomarkers and therapeutic targets for esophageal cancer.
format	article
author	Ling Wei Jujie Sun Nasha Zhang Yue Shen Teng Wang Zengjun Li Ming Yang
author_facet	Ling Wei Jujie Sun Nasha Zhang Yue Shen Teng Wang Zengjun Li Ming Yang
author_sort	Ling Wei
title	Novel Implications of MicroRNAs, Long Non-coding RNAs and Circular RNAs in Drug Resistance of Esophageal Cancer
title_short	Novel Implications of MicroRNAs, Long Non-coding RNAs and Circular RNAs in Drug Resistance of Esophageal Cancer
title_full	Novel Implications of MicroRNAs, Long Non-coding RNAs and Circular RNAs in Drug Resistance of Esophageal Cancer
title_fullStr	Novel Implications of MicroRNAs, Long Non-coding RNAs and Circular RNAs in Drug Resistance of Esophageal Cancer
title_full_unstemmed	Novel Implications of MicroRNAs, Long Non-coding RNAs and Circular RNAs in Drug Resistance of Esophageal Cancer
title_sort	novel implications of micrornas, long non-coding rnas and circular rnas in drug resistance of esophageal cancer
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/120ec580cf31457798702ef13132b2c7
work_keys_str_mv	AT lingwei novelimplicationsofmicrornaslongnoncodingrnasandcircularrnasindrugresistanceofesophagealcancer AT jujiesun novelimplicationsofmicrornaslongnoncodingrnasandcircularrnasindrugresistanceofesophagealcancer AT nashazhang novelimplicationsofmicrornaslongnoncodingrnasandcircularrnasindrugresistanceofesophagealcancer AT yueshen novelimplicationsofmicrornaslongnoncodingrnasandcircularrnasindrugresistanceofesophagealcancer AT tengwang novelimplicationsofmicrornaslongnoncodingrnasandcircularrnasindrugresistanceofesophagealcancer AT zengjunli novelimplicationsofmicrornaslongnoncodingrnasandcircularrnasindrugresistanceofesophagealcancer AT mingyang novelimplicationsofmicrornaslongnoncodingrnasandcircularrnasindrugresistanceofesophagealcancer
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Novel Implications of MicroRNAs, Long Non-coding RNAs and Circular RNAs in Drug Resistance of Esophageal Cancer

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