Comorbidity index for predicting mortality at 6 months after reperfusion therapy

Abstract The eligibility of reperfusion therapy has been expanded to increase the number of patients. However, it remains unclear the reperfusion therapy will be beneficial in stroke patients with various comorbidities. We developed a reperfusion comorbidity index for predicting 6-month mortality in...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Hyo Suk Nam, Young Dae Kim, Joonsang Yoo, Hyungjong Park, Byung Moon Kim, Oh Young Bang, Hyeon Chang Kim, Euna Han, Dong Joon Kim, Joonyung Heo, Minyoung Kim, Jin Kyo Choi, Kyung-Yul Lee, Hye Sun Lee, Dong Hoon Shin, Hye-Yeon Choi, Sung-Il Sohn, Jeong-Ho Hong, Jong Yun Lee, Jang-Hyun Baek, Gyu Sik Kim, Woo-Keun Seo, Jong-Won Chung, Seo Hyun Kim, Tae-Jin Song, Sang Won Han, Joong Hyun Park, Jinkwon Kim, Yo Han Jung, Han-Jin Cho, Seong Hwan Ahn, Sung Ik Lee, Kwon-Duk Seo, Ji Hoe Heo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/121053f79b114cef8961fae76b0e4418
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:121053f79b114cef8961fae76b0e4418
record_format	dspace
spelling	oai:doaj.org-article:121053f79b114cef8961fae76b0e44182021-12-02T13:17:49ZComorbidity index for predicting mortality at 6 months after reperfusion therapy10.1038/s41598-021-85390-42045-2322https://doaj.org/article/121053f79b114cef8961fae76b0e44182021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85390-4https://doaj.org/toc/2045-2322Abstract The eligibility of reperfusion therapy has been expanded to increase the number of patients. However, it remains unclear the reperfusion therapy will be beneficial in stroke patients with various comorbidities. We developed a reperfusion comorbidity index for predicting 6-month mortality in patients with acute stroke receiving reperfusion therapy. The 19 comorbidities included in the Charlson comorbidity index were adopted and modified. We developed a statistical model and it was validated using data from a prospective cohort. Among 1026 patients in the retrospective nationwide reperfusion therapy registry, 845 (82.3%) had at least one comorbidity. As the number of comorbidities increased, the likelihood of mortality within 6 months also increased (p < 0.001). Six out of the 19 comorbidities were included for developing the reperfusion comorbidity index on the basis of the odds ratios in the multivariate logistic regression analysis. This index showed good prediction of 6-month mortality in the retrospective cohort (area under the curve [AUC], 0.747; 95% CI, 0.704–0.790) and in 333 patients in the prospective cohort (AUC, 0.784; 95% CI, 0.709–0.859). Consideration of comorbidities might be helpful for the prediction of the 6-month mortality in patients with acute ischemic stroke who receive reperfusion therapy.Hyo Suk NamYoung Dae KimJoonsang YooHyungjong ParkByung Moon KimOh Young BangHyeon Chang KimEuna HanDong Joon KimJoonyung HeoMinyoung KimJin Kyo ChoiKyung-Yul LeeHye Sun LeeDong Hoon ShinHye-Yeon ChoiSung-Il SohnJeong-Ho HongJong Yun LeeJang-Hyun BaekGyu Sik KimWoo-Keun SeoJong-Won ChungSeo Hyun KimTae-Jin SongSang Won HanJoong Hyun ParkJinkwon KimYo Han JungHan-Jin ChoSeong Hwan AhnSung Ik LeeKwon-Duk SeoJi Hoe HeoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hyo Suk Nam Young Dae Kim Joonsang Yoo Hyungjong Park Byung Moon Kim Oh Young Bang Hyeon Chang Kim Euna Han Dong Joon Kim Joonyung Heo Minyoung Kim Jin Kyo Choi Kyung-Yul Lee Hye Sun Lee Dong Hoon Shin Hye-Yeon Choi Sung-Il Sohn Jeong-Ho Hong Jong Yun Lee Jang-Hyun Baek Gyu Sik Kim Woo-Keun Seo Jong-Won Chung Seo Hyun Kim Tae-Jin Song Sang Won Han Joong Hyun Park Jinkwon Kim Yo Han Jung Han-Jin Cho Seong Hwan Ahn Sung Ik Lee Kwon-Duk Seo Ji Hoe Heo Comorbidity index for predicting mortality at 6 months after reperfusion therapy
description	Abstract The eligibility of reperfusion therapy has been expanded to increase the number of patients. However, it remains unclear the reperfusion therapy will be beneficial in stroke patients with various comorbidities. We developed a reperfusion comorbidity index for predicting 6-month mortality in patients with acute stroke receiving reperfusion therapy. The 19 comorbidities included in the Charlson comorbidity index were adopted and modified. We developed a statistical model and it was validated using data from a prospective cohort. Among 1026 patients in the retrospective nationwide reperfusion therapy registry, 845 (82.3%) had at least one comorbidity. As the number of comorbidities increased, the likelihood of mortality within 6 months also increased (p < 0.001). Six out of the 19 comorbidities were included for developing the reperfusion comorbidity index on the basis of the odds ratios in the multivariate logistic regression analysis. This index showed good prediction of 6-month mortality in the retrospective cohort (area under the curve [AUC], 0.747; 95% CI, 0.704–0.790) and in 333 patients in the prospective cohort (AUC, 0.784; 95% CI, 0.709–0.859). Consideration of comorbidities might be helpful for the prediction of the 6-month mortality in patients with acute ischemic stroke who receive reperfusion therapy.
format	article
author	Hyo Suk Nam Young Dae Kim Joonsang Yoo Hyungjong Park Byung Moon Kim Oh Young Bang Hyeon Chang Kim Euna Han Dong Joon Kim Joonyung Heo Minyoung Kim Jin Kyo Choi Kyung-Yul Lee Hye Sun Lee Dong Hoon Shin Hye-Yeon Choi Sung-Il Sohn Jeong-Ho Hong Jong Yun Lee Jang-Hyun Baek Gyu Sik Kim Woo-Keun Seo Jong-Won Chung Seo Hyun Kim Tae-Jin Song Sang Won Han Joong Hyun Park Jinkwon Kim Yo Han Jung Han-Jin Cho Seong Hwan Ahn Sung Ik Lee Kwon-Duk Seo Ji Hoe Heo
author_facet	Hyo Suk Nam Young Dae Kim Joonsang Yoo Hyungjong Park Byung Moon Kim Oh Young Bang Hyeon Chang Kim Euna Han Dong Joon Kim Joonyung Heo Minyoung Kim Jin Kyo Choi Kyung-Yul Lee Hye Sun Lee Dong Hoon Shin Hye-Yeon Choi Sung-Il Sohn Jeong-Ho Hong Jong Yun Lee Jang-Hyun Baek Gyu Sik Kim Woo-Keun Seo Jong-Won Chung Seo Hyun Kim Tae-Jin Song Sang Won Han Joong Hyun Park Jinkwon Kim Yo Han Jung Han-Jin Cho Seong Hwan Ahn Sung Ik Lee Kwon-Duk Seo Ji Hoe Heo
author_sort	Hyo Suk Nam
title	Comorbidity index for predicting mortality at 6 months after reperfusion therapy
title_short	Comorbidity index for predicting mortality at 6 months after reperfusion therapy
title_full	Comorbidity index for predicting mortality at 6 months after reperfusion therapy
title_fullStr	Comorbidity index for predicting mortality at 6 months after reperfusion therapy
title_full_unstemmed	Comorbidity index for predicting mortality at 6 months after reperfusion therapy
title_sort	comorbidity index for predicting mortality at 6 months after reperfusion therapy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/121053f79b114cef8961fae76b0e4418
work_keys_str_mv	AT hyosuknam comorbidityindexforpredictingmortalityat6monthsafterreperfusiontherapy AT youngdaekim comorbidityindexforpredictingmortalityat6monthsafterreperfusiontherapy AT joonsangyoo comorbidityindexforpredictingmortalityat6monthsafterreperfusiontherapy AT hyungjongpark comorbidityindexforpredictingmortalityat6monthsafterreperfusiontherapy AT byungmoonkim comorbidityindexforpredictingmortalityat6monthsafterreperfusiontherapy AT ohyoungbang comorbidityindexforpredictingmortalityat6monthsafterreperfusiontherapy AT hyeonchangkim comorbidityindexforpredictingmortalityat6monthsafterreperfusiontherapy AT eunahan comorbidityindexforpredictingmortalityat6monthsafterreperfusiontherapy AT dongjoonkim comorbidityindexforpredictingmortalityat6monthsafterreperfusiontherapy AT joonyungheo comorbidityindexforpredictingmortalityat6monthsafterreperfusiontherapy AT minyoungkim comorbidityindexforpredictingmortalityat6monthsafterreperfusiontherapy AT jinkyochoi comorbidityindexforpredictingmortalityat6monthsafterreperfusiontherapy AT kyungyullee comorbidityindexforpredictingmortalityat6monthsafterreperfusiontherapy AT hyesunlee comorbidityindexforpredictingmortalityat6monthsafterreperfusiontherapy AT donghoonshin comorbidityindexforpredictingmortalityat6monthsafterreperfusiontherapy AT hyeyeonchoi comorbidityindexforpredictingmortalityat6monthsafterreperfusiontherapy AT sungilsohn comorbidityindexforpredictingmortalityat6monthsafterreperfusiontherapy AT jeonghohong comorbidityindexforpredictingmortalityat6monthsafterreperfusiontherapy AT jongyunlee comorbidityindexforpredictingmortalityat6monthsafterreperfusiontherapy AT janghyunbaek comorbidityindexforpredictingmortalityat6monthsafterreperfusiontherapy AT gyusikkim comorbidityindexforpredictingmortalityat6monthsafterreperfusiontherapy AT wookeunseo comorbidityindexforpredictingmortalityat6monthsafterreperfusiontherapy AT jongwonchung comorbidityindexforpredictingmortalityat6monthsafterreperfusiontherapy AT seohyunkim comorbidityindexforpredictingmortalityat6monthsafterreperfusiontherapy AT taejinsong comorbidityindexforpredictingmortalityat6monthsafterreperfusiontherapy AT sangwonhan comorbidityindexforpredictingmortalityat6monthsafterreperfusiontherapy AT joonghyunpark comorbidityindexforpredictingmortalityat6monthsafterreperfusiontherapy AT jinkwonkim comorbidityindexforpredictingmortalityat6monthsafterreperfusiontherapy AT yohanjung comorbidityindexforpredictingmortalityat6monthsafterreperfusiontherapy AT hanjincho comorbidityindexforpredictingmortalityat6monthsafterreperfusiontherapy AT seonghwanahn comorbidityindexforpredictingmortalityat6monthsafterreperfusiontherapy AT sungiklee comorbidityindexforpredictingmortalityat6monthsafterreperfusiontherapy AT kwondukseo comorbidityindexforpredictingmortalityat6monthsafterreperfusiontherapy AT jihoeheo comorbidityindexforpredictingmortalityat6monthsafterreperfusiontherapy
_version_	1718393316293214208

Comorbidity index for predicting mortality at 6 months after reperfusion therapy

Ejemplares similares