Chapare virus, a newly discovered arenavirus isolated from a fatal hemorrhagic fever case in Bolivia.
A small focus of hemorrhagic fever (HF) cases occurred near Cochabamba, Bolivia, in December 2003 and January 2004. Specimens were available from only one fatal case, which had a clinical course that included fever, headache, arthralgia, myalgia, and vomiting with subsequent deterioration and multip...
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Public Library of Science (PLoS)
2008
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oai:doaj.org-article:1210ac470f3049b39ca266aa59a84aa62021-11-25T05:46:37ZChapare virus, a newly discovered arenavirus isolated from a fatal hemorrhagic fever case in Bolivia.1553-73661553-737410.1371/journal.ppat.1000047https://doaj.org/article/1210ac470f3049b39ca266aa59a84aa62008-04-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18421377/pdf/?tool=EBIhttps://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374A small focus of hemorrhagic fever (HF) cases occurred near Cochabamba, Bolivia, in December 2003 and January 2004. Specimens were available from only one fatal case, which had a clinical course that included fever, headache, arthralgia, myalgia, and vomiting with subsequent deterioration and multiple hemorrhagic signs. A non-cytopathic virus was isolated from two of the patient serum samples, and identified as an arenavirus by IFA staining with a rabbit polyvalent antiserum raised against South American arenaviruses known to be associated with HF (Guanarito, Machupo, and Sabiá). RT-PCR analysis and subsequent analysis of the complete virus S and L RNA segment sequences identified the virus as a member of the New World Clade B arenaviruses, which includes all the pathogenic South American arenaviruses. The virus was shown to be most closely related to Sabiá virus, but with 26% and 30% nucleotide difference in the S and L segments, and 26%, 28%, 15% and 22% amino acid differences for the L, Z, N, and GP proteins, respectively, indicating the virus represents a newly discovered arenavirus, for which we propose the name Chapare virus. In conclusion, two different arenaviruses, Machupo and Chapare, can be associated with severe HF cases in Bolivia.Simon DelgadoBobbie R EricksonRoberto AgudoPatrick J BlairEfrain VallejoCésar G AlbariñoJorge VargasJames A ComerPierre E RollinThomas G KsiazekJames G OlsonStuart T NicholPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 4, Iss 4, p e1000047 (2008) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 |
| spellingShingle |
Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Simon Delgado Bobbie R Erickson Roberto Agudo Patrick J Blair Efrain Vallejo César G Albariño Jorge Vargas James A Comer Pierre E Rollin Thomas G Ksiazek James G Olson Stuart T Nichol Chapare virus, a newly discovered arenavirus isolated from a fatal hemorrhagic fever case in Bolivia. |
| description |
A small focus of hemorrhagic fever (HF) cases occurred near Cochabamba, Bolivia, in December 2003 and January 2004. Specimens were available from only one fatal case, which had a clinical course that included fever, headache, arthralgia, myalgia, and vomiting with subsequent deterioration and multiple hemorrhagic signs. A non-cytopathic virus was isolated from two of the patient serum samples, and identified as an arenavirus by IFA staining with a rabbit polyvalent antiserum raised against South American arenaviruses known to be associated with HF (Guanarito, Machupo, and Sabiá). RT-PCR analysis and subsequent analysis of the complete virus S and L RNA segment sequences identified the virus as a member of the New World Clade B arenaviruses, which includes all the pathogenic South American arenaviruses. The virus was shown to be most closely related to Sabiá virus, but with 26% and 30% nucleotide difference in the S and L segments, and 26%, 28%, 15% and 22% amino acid differences for the L, Z, N, and GP proteins, respectively, indicating the virus represents a newly discovered arenavirus, for which we propose the name Chapare virus. In conclusion, two different arenaviruses, Machupo and Chapare, can be associated with severe HF cases in Bolivia. |
| format |
article |
| author |
Simon Delgado Bobbie R Erickson Roberto Agudo Patrick J Blair Efrain Vallejo César G Albariño Jorge Vargas James A Comer Pierre E Rollin Thomas G Ksiazek James G Olson Stuart T Nichol |
| author_facet |
Simon Delgado Bobbie R Erickson Roberto Agudo Patrick J Blair Efrain Vallejo César G Albariño Jorge Vargas James A Comer Pierre E Rollin Thomas G Ksiazek James G Olson Stuart T Nichol |
| author_sort |
Simon Delgado |
| title |
Chapare virus, a newly discovered arenavirus isolated from a fatal hemorrhagic fever case in Bolivia. |
| title_short |
Chapare virus, a newly discovered arenavirus isolated from a fatal hemorrhagic fever case in Bolivia. |
| title_full |
Chapare virus, a newly discovered arenavirus isolated from a fatal hemorrhagic fever case in Bolivia. |
| title_fullStr |
Chapare virus, a newly discovered arenavirus isolated from a fatal hemorrhagic fever case in Bolivia. |
| title_full_unstemmed |
Chapare virus, a newly discovered arenavirus isolated from a fatal hemorrhagic fever case in Bolivia. |
| title_sort |
chapare virus, a newly discovered arenavirus isolated from a fatal hemorrhagic fever case in bolivia. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2008 |
| url |
https://doaj.org/article/1210ac470f3049b39ca266aa59a84aa6 |
| work_keys_str_mv |
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