The biomarker and causal roles of homoarginine in the development of cardiometabolic diseases: an observational and Mendelian randomization analysis

Abstract High L-homoarginine (hArg) levels are directly associated with several risk factors for cardiometabolic diseases whereas low levels predict increased mortality in prospective studies. The biomarker role of hArg in young adults remains unknown. To study the predictive value of hArg in the de...

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Autores principales:	Ilkka Seppälä, Niku Oksala, Antti Jula, Antti J. Kangas, Pasi Soininen, Nina Hutri-Kähönen, Winfried März, Andreas Meinitzer, Markus Juonala, Mika Kähönen, Olli T. Raitakari, Terho Lehtimäki
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1211d06858ed48568b2b0c3cee883494
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spelling	oai:doaj.org-article:1211d06858ed48568b2b0c3cee8834942021-12-02T11:52:44ZThe biomarker and causal roles of homoarginine in the development of cardiometabolic diseases: an observational and Mendelian randomization analysis10.1038/s41598-017-01274-62045-2322https://doaj.org/article/1211d06858ed48568b2b0c3cee8834942017-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01274-6https://doaj.org/toc/2045-2322Abstract High L-homoarginine (hArg) levels are directly associated with several risk factors for cardiometabolic diseases whereas low levels predict increased mortality in prospective studies. The biomarker role of hArg in young adults remains unknown. To study the predictive value of hArg in the development of cardiometabolic risk factors and diseases, we utilized data on high-pressure liquid chromatography-measured hArg, cardiovascular risk factors, ultrasound markers of preclinical atherosclerosis and type 2 diabetes from the population-based Young Finns Study involving 2,106 young adults (54.6% females, aged 24–39). We used a Mendelian randomization approach involving tens to hundreds of thousands of individuals to test causal associations. In our 10-year follow-up analysis, hArg served as an independent predictor for future hyperglycaemia (OR 1.31, 95% CI 1.06–1.63) and abdominal obesity (OR 1.60, 95% 1.14–2.30) in men and type 2 diabetes in women (OR 1.55, 95% CI 1.02–2.41). The MR analysis revealed no evidence of causal associations between serum hArg and any of the studied cardiometabolic outcomes. In conclusion, lifetime exposure to higher levels of circulating hArg does not seem to alter cardiometabolic disease risk. Whether hArg could be used as a biomarker for identification of individuals at risk developing cardiometabolic abnormalities merits further investigation.Ilkka SeppäläNiku OksalaAntti JulaAntti J. KangasPasi SoininenNina Hutri-KähönenWinfried MärzAndreas MeinitzerMarkus JuonalaMika KähönenOlli T. RaitakariTerho LehtimäkiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ilkka Seppälä Niku Oksala Antti Jula Antti J. Kangas Pasi Soininen Nina Hutri-Kähönen Winfried März Andreas Meinitzer Markus Juonala Mika Kähönen Olli T. Raitakari Terho Lehtimäki The biomarker and causal roles of homoarginine in the development of cardiometabolic diseases: an observational and Mendelian randomization analysis
description	Abstract High L-homoarginine (hArg) levels are directly associated with several risk factors for cardiometabolic diseases whereas low levels predict increased mortality in prospective studies. The biomarker role of hArg in young adults remains unknown. To study the predictive value of hArg in the development of cardiometabolic risk factors and diseases, we utilized data on high-pressure liquid chromatography-measured hArg, cardiovascular risk factors, ultrasound markers of preclinical atherosclerosis and type 2 diabetes from the population-based Young Finns Study involving 2,106 young adults (54.6% females, aged 24–39). We used a Mendelian randomization approach involving tens to hundreds of thousands of individuals to test causal associations. In our 10-year follow-up analysis, hArg served as an independent predictor for future hyperglycaemia (OR 1.31, 95% CI 1.06–1.63) and abdominal obesity (OR 1.60, 95% 1.14–2.30) in men and type 2 diabetes in women (OR 1.55, 95% CI 1.02–2.41). The MR analysis revealed no evidence of causal associations between serum hArg and any of the studied cardiometabolic outcomes. In conclusion, lifetime exposure to higher levels of circulating hArg does not seem to alter cardiometabolic disease risk. Whether hArg could be used as a biomarker for identification of individuals at risk developing cardiometabolic abnormalities merits further investigation.
format	article
author	Ilkka Seppälä Niku Oksala Antti Jula Antti J. Kangas Pasi Soininen Nina Hutri-Kähönen Winfried März Andreas Meinitzer Markus Juonala Mika Kähönen Olli T. Raitakari Terho Lehtimäki
author_facet	Ilkka Seppälä Niku Oksala Antti Jula Antti J. Kangas Pasi Soininen Nina Hutri-Kähönen Winfried März Andreas Meinitzer Markus Juonala Mika Kähönen Olli T. Raitakari Terho Lehtimäki
author_sort	Ilkka Seppälä
title	The biomarker and causal roles of homoarginine in the development of cardiometabolic diseases: an observational and Mendelian randomization analysis
title_short	The biomarker and causal roles of homoarginine in the development of cardiometabolic diseases: an observational and Mendelian randomization analysis
title_full	The biomarker and causal roles of homoarginine in the development of cardiometabolic diseases: an observational and Mendelian randomization analysis
title_fullStr	The biomarker and causal roles of homoarginine in the development of cardiometabolic diseases: an observational and Mendelian randomization analysis
title_full_unstemmed	The biomarker and causal roles of homoarginine in the development of cardiometabolic diseases: an observational and Mendelian randomization analysis
title_sort	biomarker and causal roles of homoarginine in the development of cardiometabolic diseases: an observational and mendelian randomization analysis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/1211d06858ed48568b2b0c3cee883494
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The biomarker and causal roles of homoarginine in the development of cardiometabolic diseases: an observational and Mendelian randomization analysis

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