Insights from zebrafish and mouse models on the activity and safety of ar-turmerone as a potential drug candidate for the treatment of epilepsy.

In a previous study, we uncovered the anticonvulsant properties of turmeric oil and its sesquiterpenoids (ar-turmerone, α-, β-turmerone and α-atlantone) in both zebrafish and mouse models of chemically-induced seizures using pentylenetetrazole (PTZ). In this follow-up study, we aimed at evaluating t...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Adriana Monserrath Orellana-Paucar, Tatiana Afrikanova, Joice Thomas, Yelaman K Aibuldinov, Wim Dehaen, Peter A M de Witte, Camila V Esguerra
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1213b325c15d4be3bc4e47acd0b436e8
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:1213b325c15d4be3bc4e47acd0b436e8
record_format	dspace
spelling	oai:doaj.org-article:1213b325c15d4be3bc4e47acd0b436e82021-11-18T08:42:06ZInsights from zebrafish and mouse models on the activity and safety of ar-turmerone as a potential drug candidate for the treatment of epilepsy.1932-620310.1371/journal.pone.0081634https://doaj.org/article/1213b325c15d4be3bc4e47acd0b436e82013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24349101/?tool=EBIhttps://doaj.org/toc/1932-6203In a previous study, we uncovered the anticonvulsant properties of turmeric oil and its sesquiterpenoids (ar-turmerone, α-, β-turmerone and α-atlantone) in both zebrafish and mouse models of chemically-induced seizures using pentylenetetrazole (PTZ). In this follow-up study, we aimed at evaluating the anticonvulsant activity of ar-turmerone further. A more in-depth anticonvulsant evaluation of ar-turmerone was therefore carried out in the i.v. PTZ and 6-Hz mouse models. The potential toxic effects of ar-turmerone were evaluated using the beam walking test to assess mouse motor function and balance. In addition, determination of the concentration-time profile of ar-turmerone was carried out for a more extended evaluation of its bioavailability in the mouse brain. Ar-turmerone displayed anticonvulsant properties in both acute seizure models in mice and modulated the expression patterns of two seizure-related genes (c-fos and brain-derived neurotrophic factor [bdnf]) in zebrafish. Importantly, no effects on motor function and balance were observed in mice after treatment with ar-turmerone even after administering a dose 500-fold higher than the effective dose in the 6-Hz model. In addition, quantification of its concentration in mouse brains revealed rapid absorption after i.p. administration, capacity to cross the BBB and long-term brain residence. Hence, our results provide additional information on the anticonvulsant properties of ar-turmerone and support further evaluation towards elucidating its mechanism of action, bioavailability, toxicity and potential clinical application.Adriana Monserrath Orellana-PaucarTatiana AfrikanovaJoice ThomasYelaman K AibuldinovWim DehaenPeter A M de WitteCamila V EsguerraPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 12, p e81634 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Adriana Monserrath Orellana-Paucar Tatiana Afrikanova Joice Thomas Yelaman K Aibuldinov Wim Dehaen Peter A M de Witte Camila V Esguerra Insights from zebrafish and mouse models on the activity and safety of ar-turmerone as a potential drug candidate for the treatment of epilepsy.
description	In a previous study, we uncovered the anticonvulsant properties of turmeric oil and its sesquiterpenoids (ar-turmerone, α-, β-turmerone and α-atlantone) in both zebrafish and mouse models of chemically-induced seizures using pentylenetetrazole (PTZ). In this follow-up study, we aimed at evaluating the anticonvulsant activity of ar-turmerone further. A more in-depth anticonvulsant evaluation of ar-turmerone was therefore carried out in the i.v. PTZ and 6-Hz mouse models. The potential toxic effects of ar-turmerone were evaluated using the beam walking test to assess mouse motor function and balance. In addition, determination of the concentration-time profile of ar-turmerone was carried out for a more extended evaluation of its bioavailability in the mouse brain. Ar-turmerone displayed anticonvulsant properties in both acute seizure models in mice and modulated the expression patterns of two seizure-related genes (c-fos and brain-derived neurotrophic factor [bdnf]) in zebrafish. Importantly, no effects on motor function and balance were observed in mice after treatment with ar-turmerone even after administering a dose 500-fold higher than the effective dose in the 6-Hz model. In addition, quantification of its concentration in mouse brains revealed rapid absorption after i.p. administration, capacity to cross the BBB and long-term brain residence. Hence, our results provide additional information on the anticonvulsant properties of ar-turmerone and support further evaluation towards elucidating its mechanism of action, bioavailability, toxicity and potential clinical application.
format	article
author	Adriana Monserrath Orellana-Paucar Tatiana Afrikanova Joice Thomas Yelaman K Aibuldinov Wim Dehaen Peter A M de Witte Camila V Esguerra
author_facet	Adriana Monserrath Orellana-Paucar Tatiana Afrikanova Joice Thomas Yelaman K Aibuldinov Wim Dehaen Peter A M de Witte Camila V Esguerra
author_sort	Adriana Monserrath Orellana-Paucar
title	Insights from zebrafish and mouse models on the activity and safety of ar-turmerone as a potential drug candidate for the treatment of epilepsy.
title_short	Insights from zebrafish and mouse models on the activity and safety of ar-turmerone as a potential drug candidate for the treatment of epilepsy.
title_full	Insights from zebrafish and mouse models on the activity and safety of ar-turmerone as a potential drug candidate for the treatment of epilepsy.
title_fullStr	Insights from zebrafish and mouse models on the activity and safety of ar-turmerone as a potential drug candidate for the treatment of epilepsy.
title_full_unstemmed	Insights from zebrafish and mouse models on the activity and safety of ar-turmerone as a potential drug candidate for the treatment of epilepsy.
title_sort	insights from zebrafish and mouse models on the activity and safety of ar-turmerone as a potential drug candidate for the treatment of epilepsy.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/1213b325c15d4be3bc4e47acd0b436e8
work_keys_str_mv	AT adrianamonserrathorellanapaucar insightsfromzebrafishandmousemodelsontheactivityandsafetyofarturmeroneasapotentialdrugcandidateforthetreatmentofepilepsy AT tatianaafrikanova insightsfromzebrafishandmousemodelsontheactivityandsafetyofarturmeroneasapotentialdrugcandidateforthetreatmentofepilepsy AT joicethomas insightsfromzebrafishandmousemodelsontheactivityandsafetyofarturmeroneasapotentialdrugcandidateforthetreatmentofepilepsy AT yelamankaibuldinov insightsfromzebrafishandmousemodelsontheactivityandsafetyofarturmeroneasapotentialdrugcandidateforthetreatmentofepilepsy AT wimdehaen insightsfromzebrafishandmousemodelsontheactivityandsafetyofarturmeroneasapotentialdrugcandidateforthetreatmentofepilepsy AT peteramdewitte insightsfromzebrafishandmousemodelsontheactivityandsafetyofarturmeroneasapotentialdrugcandidateforthetreatmentofepilepsy AT camilavesguerra insightsfromzebrafishandmousemodelsontheactivityandsafetyofarturmeroneasapotentialdrugcandidateforthetreatmentofepilepsy
_version_	1718421427272548352

Insights from zebrafish and mouse models on the activity and safety of ar-turmerone as a potential drug candidate for the treatment of epilepsy.

Ejemplares similares