Probing microstructural differences that manifest in human blood after taking aspirin using thixo-elasto-visco-plastic modeling and series of physical processes
Although prophylactic use of low dosage acetylsalicylic acid (aspirin) to inhibit the effects of platelet aggregation is common, a few, if any, rheological studies validating the change in the physical and mechanical properties of human blood post-aspirin administration have been reported. Recent wo...
Guardado en:
| Autores principales: | , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
AIP Publishing LLC
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/1215152b115b4e1698f2214a87fa748a |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:1215152b115b4e1698f2214a87fa748a |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:1215152b115b4e1698f2214a87fa748a2021-12-01T18:52:06ZProbing microstructural differences that manifest in human blood after taking aspirin using thixo-elasto-visco-plastic modeling and series of physical processes2158-322610.1063/5.0074608https://doaj.org/article/1215152b115b4e1698f2214a87fa748a2021-11-01T00:00:00Zhttp://dx.doi.org/10.1063/5.0074608https://doaj.org/toc/2158-3226Although prophylactic use of low dosage acetylsalicylic acid (aspirin) to inhibit the effects of platelet aggregation is common, a few, if any, rheological studies validating the change in the physical and mechanical properties of human blood post-aspirin administration have been reported. Recent work modeling the rheological behavior of thixo-elasto-visco-plastic materials, such as human blood, indicates that they have all the hallmark features of a complex material, including shear-thinning, viscoelasticity, yield stress, and thixotropy. Using human blood rheological data collected on a Discovery Hybrid Rheometer, before and after a 14-day protocol of once daily 81 mg aspirin tablet, we compare the mechanical properties with the recently published enhanced thixotropic modified Horner–Armstrong–Wagner–Beris thixo-elasto-visco-plastic model and sequence of physical processes. We do so to highlight the subtle shift in mechanical properties in terms of the “liquid-like” and “solid-like” nature of blood. We will show both before and after parametric analysis, profile, and comparison, as well as the before and after aspirin elastic and viscous properties of the human blood.Matthew ArmstrongErin MilnerDorian BaileyAndre PincotThomas BrownLam NguyenKevin O’DonovanChi NguyenTrevor CorriganAIP Publishing LLCarticlePhysicsQC1-999ENAIP Advances, Vol 11, Iss 11, Pp 115226-115226-19 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Physics QC1-999 |
| spellingShingle |
Physics QC1-999 Matthew Armstrong Erin Milner Dorian Bailey Andre Pincot Thomas Brown Lam Nguyen Kevin O’Donovan Chi Nguyen Trevor Corrigan Probing microstructural differences that manifest in human blood after taking aspirin using thixo-elasto-visco-plastic modeling and series of physical processes |
| description |
Although prophylactic use of low dosage acetylsalicylic acid (aspirin) to inhibit the effects of platelet aggregation is common, a few, if any, rheological studies validating the change in the physical and mechanical properties of human blood post-aspirin administration have been reported. Recent work modeling the rheological behavior of thixo-elasto-visco-plastic materials, such as human blood, indicates that they have all the hallmark features of a complex material, including shear-thinning, viscoelasticity, yield stress, and thixotropy. Using human blood rheological data collected on a Discovery Hybrid Rheometer, before and after a 14-day protocol of once daily 81 mg aspirin tablet, we compare the mechanical properties with the recently published enhanced thixotropic modified Horner–Armstrong–Wagner–Beris thixo-elasto-visco-plastic model and sequence of physical processes. We do so to highlight the subtle shift in mechanical properties in terms of the “liquid-like” and “solid-like” nature of blood. We will show both before and after parametric analysis, profile, and comparison, as well as the before and after aspirin elastic and viscous properties of the human blood. |
| format |
article |
| author |
Matthew Armstrong Erin Milner Dorian Bailey Andre Pincot Thomas Brown Lam Nguyen Kevin O’Donovan Chi Nguyen Trevor Corrigan |
| author_facet |
Matthew Armstrong Erin Milner Dorian Bailey Andre Pincot Thomas Brown Lam Nguyen Kevin O’Donovan Chi Nguyen Trevor Corrigan |
| author_sort |
Matthew Armstrong |
| title |
Probing microstructural differences that manifest in human blood after taking aspirin using thixo-elasto-visco-plastic modeling and series of physical processes |
| title_short |
Probing microstructural differences that manifest in human blood after taking aspirin using thixo-elasto-visco-plastic modeling and series of physical processes |
| title_full |
Probing microstructural differences that manifest in human blood after taking aspirin using thixo-elasto-visco-plastic modeling and series of physical processes |
| title_fullStr |
Probing microstructural differences that manifest in human blood after taking aspirin using thixo-elasto-visco-plastic modeling and series of physical processes |
| title_full_unstemmed |
Probing microstructural differences that manifest in human blood after taking aspirin using thixo-elasto-visco-plastic modeling and series of physical processes |
| title_sort |
probing microstructural differences that manifest in human blood after taking aspirin using thixo-elasto-visco-plastic modeling and series of physical processes |
| publisher |
AIP Publishing LLC |
| publishDate |
2021 |
| url |
https://doaj.org/article/1215152b115b4e1698f2214a87fa748a |
| work_keys_str_mv |
AT matthewarmstrong probingmicrostructuraldifferencesthatmanifestinhumanbloodaftertakingaspirinusingthixoelastoviscoplasticmodelingandseriesofphysicalprocesses AT erinmilner probingmicrostructuraldifferencesthatmanifestinhumanbloodaftertakingaspirinusingthixoelastoviscoplasticmodelingandseriesofphysicalprocesses AT probingmicrostructuraldifferencesthatmanifestinhumanbloodaftertakingaspirinusingthixoelastoviscoplasticmodelingandseriesofphysicalprocesses AT dorianbailey probingmicrostructuraldifferencesthatmanifestinhumanbloodaftertakingaspirinusingthixoelastoviscoplasticmodelingandseriesofphysicalprocesses AT probingmicrostructuraldifferencesthatmanifestinhumanbloodaftertakingaspirinusingthixoelastoviscoplasticmodelingandseriesofphysicalprocesses AT andrepincot probingmicrostructuraldifferencesthatmanifestinhumanbloodaftertakingaspirinusingthixoelastoviscoplasticmodelingandseriesofphysicalprocesses AT probingmicrostructuraldifferencesthatmanifestinhumanbloodaftertakingaspirinusingthixoelastoviscoplasticmodelingandseriesofphysicalprocesses AT thomasbrown probingmicrostructuraldifferencesthatmanifestinhumanbloodaftertakingaspirinusingthixoelastoviscoplasticmodelingandseriesofphysicalprocesses AT probingmicrostructuraldifferencesthatmanifestinhumanbloodaftertakingaspirinusingthixoelastoviscoplasticmodelingandseriesofphysicalprocesses AT lamnguyen probingmicrostructuraldifferencesthatmanifestinhumanbloodaftertakingaspirinusingthixoelastoviscoplasticmodelingandseriesofphysicalprocesses AT probingmicrostructuraldifferencesthatmanifestinhumanbloodaftertakingaspirinusingthixoelastoviscoplasticmodelingandseriesofphysicalprocesses AT kevinodonovan probingmicrostructuraldifferencesthatmanifestinhumanbloodaftertakingaspirinusingthixoelastoviscoplasticmodelingandseriesofphysicalprocesses AT probingmicrostructuraldifferencesthatmanifestinhumanbloodaftertakingaspirinusingthixoelastoviscoplasticmodelingandseriesofphysicalprocesses AT chinguyen probingmicrostructuraldifferencesthatmanifestinhumanbloodaftertakingaspirinusingthixoelastoviscoplasticmodelingandseriesofphysicalprocesses AT trevorcorrigan probingmicrostructuraldifferencesthatmanifestinhumanbloodaftertakingaspirinusingthixoelastoviscoplasticmodelingandseriesofphysicalprocesses |
| _version_ |
1718404675821109248 |