TFIIE orchestrates the recruitment of the TFIIH kinase module at promoter before release during transcription

The general transcription factors TFIIE and TFIIH assemble at the transcription start site with RNA Polymerase II. Here the authors provide evidence that the TFIIEα and TFIIEβ subunits anchor the TFIIH kinase module within the preinitiation complex before their release during transcription.

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Detalles Bibliográficos
Autores principales: Emmanuel Compe, Carlos M. Genes, Cathy Braun, Frederic Coin, Jean-Marc Egly
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Q
Acceso en línea:https://doaj.org/article/121d77056e3d4d43a399accbfabcc5df
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Sumario:The general transcription factors TFIIE and TFIIH assemble at the transcription start site with RNA Polymerase II. Here the authors provide evidence that the TFIIEα and TFIIEβ subunits anchor the TFIIH kinase module within the preinitiation complex before their release during transcription.