Hemodynamic and endotheliym-protective effects of beta-blockers in patients with chronic heart failure and atrial fibrillation ischemic origin

Aim.To evaluate the effect ofb-blockers (BB) on myocardial remodeling and endothelial adhesive function in patients with chronic heart failure (CHF) and atrial fibrillation (AF) of ischemic origin. Material and methods.The study included 77 patients with functional class IIIII CHF and AF who had...

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Autores principales:	Aliara N. Zakirova, Elvina R. Abdiukova, Vitalii V. Viktorov, Nelli E. Zakirova, Dinara F. Nizamova
Formato:	article
Lenguaje:	EN RU
Publicado:	Concilium Medicum 2020
Materias:	chronic heart failure atrial fibrillation carvedilol myocardial remodeling intercellular adhesion molecules Diseases of the circulatory (Cardiovascular) system RC666-701 Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/121ea309a7804670bbad9176b9a9ad0c
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spelling	oai:doaj.org-article:121ea309a7804670bbad9176b9a9ad0c2021-12-01T22:07:01ZHemodynamic and endotheliym-protective effects of beta-blockers in patients with chronic heart failure and atrial fibrillation ischemic origin2221-71852658-570710.26442/22217185.2020.2.200230https://doaj.org/article/121ea309a7804670bbad9176b9a9ad0c2020-09-01T00:00:00Zhttps://cardiosomatics.orscience.ru/2221-7185/article/viewFile/46018/31022https://doaj.org/toc/2221-7185https://doaj.org/toc/2658-5707Aim.To evaluate the effect ofb-blockers (BB) on myocardial remodeling and endothelial adhesive function in patients with chronic heart failure (CHF) and atrial fibrillation (AF) of ischemic origin. Material and methods.The study included 77 patients with functional class IIIII CHF and AF who had previously suffered a large-focalQ-myocardial infarction. Patients were randomized into 2 groups, comparable in clinical and instrumental characteristics and homogeneous in basic therapy of CHF and AF. Group 1 included 40 patients who took carvedilol for 24 weeks as part of the basic therapy of CHF and AF, and group 2 included 37 patients who received metoprolol tartrate. We used clinical and instrumental (echocardiography, 6-minute walking test, clinical assessment scale) and enzyme immunoassay (analysis of the level of soluble molecules of intercellular adhesion sVCAM-1 and sE-selectin) research methods. Results.The use of carvedilol a non-cardioselective BB that performsa1,b1andb2-adrenoblockade, andb1-selective, short- acting BB metoprolol tartrate as part of basic therapy improved the clinical condition and physical performance of patients with CHF and AF. It was found that carvedilol more significantly than metoprolol affects the state of intracardiac hemodynamics, slows down the processes of remodeling of the left atrium and left ventricle, increases the contractile function of the myocardium. Carvedilol as part of basic therapy reduces endothelial adhesion and inhibits the overexpression of intercellular adhesion molecules sVCAM-1 and sE-selectin, and when using metoprolol tartrate, there is only a tendency to decrease these indicators. Conclusion.Carvedilol as part of the basic therapy of CHF and AF has significant endothelial-protective and clinical-hemodynamic effects, positively affects the adhesive function of the endothelium and the processes of left atrium and left ventricle remodeling.Aliara N. ZakirovaElvina R. AbdiukovaVitalii V. ViktorovNelli E. ZakirovaDinara F. NizamovaConcilium Medicumarticlechronic heart failureatrial fibrillationcarvedilolmyocardial remodelingintercellular adhesion moleculesDiseases of the circulatory (Cardiovascular) systemRC666-701Diseases of the endocrine glands. Clinical endocrinologyRC648-665ENRUКардиоСоматика, Vol 11, Iss 2, Pp 6-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	chronic heart failure atrial fibrillation carvedilol myocardial remodeling intercellular adhesion molecules Diseases of the circulatory (Cardiovascular) system RC666-701 Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	chronic heart failure atrial fibrillation carvedilol myocardial remodeling intercellular adhesion molecules Diseases of the circulatory (Cardiovascular) system RC666-701 Diseases of the endocrine glands. Clinical endocrinology RC648-665 Aliara N. Zakirova Elvina R. Abdiukova Vitalii V. Viktorov Nelli E. Zakirova Dinara F. Nizamova Hemodynamic and endotheliym-protective effects of beta-blockers in patients with chronic heart failure and atrial fibrillation ischemic origin
description	Aim.To evaluate the effect ofb-blockers (BB) on myocardial remodeling and endothelial adhesive function in patients with chronic heart failure (CHF) and atrial fibrillation (AF) of ischemic origin. Material and methods.The study included 77 patients with functional class IIIII CHF and AF who had previously suffered a large-focalQ-myocardial infarction. Patients were randomized into 2 groups, comparable in clinical and instrumental characteristics and homogeneous in basic therapy of CHF and AF. Group 1 included 40 patients who took carvedilol for 24 weeks as part of the basic therapy of CHF and AF, and group 2 included 37 patients who received metoprolol tartrate. We used clinical and instrumental (echocardiography, 6-minute walking test, clinical assessment scale) and enzyme immunoassay (analysis of the level of soluble molecules of intercellular adhesion sVCAM-1 and sE-selectin) research methods. Results.The use of carvedilol a non-cardioselective BB that performsa1,b1andb2-adrenoblockade, andb1-selective, short- acting BB metoprolol tartrate as part of basic therapy improved the clinical condition and physical performance of patients with CHF and AF. It was found that carvedilol more significantly than metoprolol affects the state of intracardiac hemodynamics, slows down the processes of remodeling of the left atrium and left ventricle, increases the contractile function of the myocardium. Carvedilol as part of basic therapy reduces endothelial adhesion and inhibits the overexpression of intercellular adhesion molecules sVCAM-1 and sE-selectin, and when using metoprolol tartrate, there is only a tendency to decrease these indicators. Conclusion.Carvedilol as part of the basic therapy of CHF and AF has significant endothelial-protective and clinical-hemodynamic effects, positively affects the adhesive function of the endothelium and the processes of left atrium and left ventricle remodeling.
format	article
author	Aliara N. Zakirova Elvina R. Abdiukova Vitalii V. Viktorov Nelli E. Zakirova Dinara F. Nizamova
author_facet	Aliara N. Zakirova Elvina R. Abdiukova Vitalii V. Viktorov Nelli E. Zakirova Dinara F. Nizamova
author_sort	Aliara N. Zakirova
title	Hemodynamic and endotheliym-protective effects of beta-blockers in patients with chronic heart failure and atrial fibrillation ischemic origin
title_short	Hemodynamic and endotheliym-protective effects of beta-blockers in patients with chronic heart failure and atrial fibrillation ischemic origin
title_full	Hemodynamic and endotheliym-protective effects of beta-blockers in patients with chronic heart failure and atrial fibrillation ischemic origin
title_fullStr	Hemodynamic and endotheliym-protective effects of beta-blockers in patients with chronic heart failure and atrial fibrillation ischemic origin
title_full_unstemmed	Hemodynamic and endotheliym-protective effects of beta-blockers in patients with chronic heart failure and atrial fibrillation ischemic origin
title_sort	hemodynamic and endotheliym-protective effects of beta-blockers in patients with chronic heart failure and atrial fibrillation ischemic origin
publisher	Concilium Medicum
publishDate	2020
url	https://doaj.org/article/121ea309a7804670bbad9176b9a9ad0c
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Hemodynamic and endotheliym-protective effects of beta-blockers in patients with chronic heart failure and atrial fibrillation ischemic origin

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