Sex bias in CNS autoimmune disease mediated by androgen control of autoimmune regulator

Males are less susceptible to autoimmune diseases due to immunomodulatory effects of androgen. Here the authors show that androgen receptor upregulates Aire and Aire-dependent transcription in the thymic epithelium, and that Aire is required for androgen-mediated suppression of experimental autoimmu...

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Autores principales:	Meng-Lei Zhu, Pearl Bakhru, Bridget Conley, Jennifer S. Nelson, Meghan Free, Aaron Martin, Joshua Starmer, Elizabeth M. Wilson, Maureen A. Su
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1221cac6180d456f84a5102f730cd069
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spelling	oai:doaj.org-article:1221cac6180d456f84a5102f730cd0692021-12-02T17:32:36ZSex bias in CNS autoimmune disease mediated by androgen control of autoimmune regulator10.1038/ncomms113502041-1723https://doaj.org/article/1221cac6180d456f84a5102f730cd0692016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11350https://doaj.org/toc/2041-1723Males are less susceptible to autoimmune diseases due to immunomodulatory effects of androgen. Here the authors show that androgen receptor upregulates Aire and Aire-dependent transcription in the thymic epithelium, and that Aire is required for androgen-mediated suppression of experimental autoimmune encephalitis.Meng-Lei ZhuPearl BakhruBridget ConleyJennifer S. NelsonMeghan FreeAaron MartinJoshua StarmerElizabeth M. WilsonMaureen A. SuNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Meng-Lei Zhu Pearl Bakhru Bridget Conley Jennifer S. Nelson Meghan Free Aaron Martin Joshua Starmer Elizabeth M. Wilson Maureen A. Su Sex bias in CNS autoimmune disease mediated by androgen control of autoimmune regulator
description	Males are less susceptible to autoimmune diseases due to immunomodulatory effects of androgen. Here the authors show that androgen receptor upregulates Aire and Aire-dependent transcription in the thymic epithelium, and that Aire is required for androgen-mediated suppression of experimental autoimmune encephalitis.
format	article
author	Meng-Lei Zhu Pearl Bakhru Bridget Conley Jennifer S. Nelson Meghan Free Aaron Martin Joshua Starmer Elizabeth M. Wilson Maureen A. Su
author_facet	Meng-Lei Zhu Pearl Bakhru Bridget Conley Jennifer S. Nelson Meghan Free Aaron Martin Joshua Starmer Elizabeth M. Wilson Maureen A. Su
author_sort	Meng-Lei Zhu
title	Sex bias in CNS autoimmune disease mediated by androgen control of autoimmune regulator
title_short	Sex bias in CNS autoimmune disease mediated by androgen control of autoimmune regulator
title_full	Sex bias in CNS autoimmune disease mediated by androgen control of autoimmune regulator
title_fullStr	Sex bias in CNS autoimmune disease mediated by androgen control of autoimmune regulator
title_full_unstemmed	Sex bias in CNS autoimmune disease mediated by androgen control of autoimmune regulator
title_sort	sex bias in cns autoimmune disease mediated by androgen control of autoimmune regulator
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/1221cac6180d456f84a5102f730cd069
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Sex bias in CNS autoimmune disease mediated by androgen control of autoimmune regulator

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